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| Histol. Histopathol. Jan (2003); 18(1):135-42 | |
| Immunohistochemical localization of human fructose-1,6-bisphosphatase in subcellular structures of myocytes. | |
| Gizak A, Rakus D, Dzugaj A | |
| Department of Animal Physiology, Institute of Zoology, Wroclaw Unviersity, Cybulskiego 30, 50-205 Wroclaw, Poland. | |
| Abstract: The localization of fructose-1,6-bisphosphatase (FBPase) in human skeletal muscle was determined immunohistochemically using polyclonal antibodies. Light microscopy analysis, confirmed with the use of confocal microscopy, indicated that the enzyme is localized on both sides of the Z line of myocytes. The immunohistochemical investigation was confirmed by a co-sedimentation experiment which revealed that muscle FBPase binds strongly to alpha-actinin--a major structural protein of the Z line. This is the first report on localization of FBPase in skeletal muscle tissue. | |
| [PUBMED: 12507293] |   |
| Copyright © 2009, Tyers Lab, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved. |
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| BioGRID: A General Repository for Interaction Datasets. Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers. Nucleic Acids Res. Jan 1;34:D535-9. |