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| Mol. Cell. Biol. Dec (1999); 19(12):8526-35 | |
| The zinc finger-associated SCAN box is a conserved oligomerization domain. | |
| Williams AJ, Blacklow SC, Collins T | |
| Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. | |
| Abstract: A number of Cys(2)His(2) zinc finger proteins contain a highly conserved amino-terminal motif termed the SCAN domain. This element is an 80-residue, leucine-rich region that contains three segments strongly predicted to be alpha-helices. In this report, we show that the SCAN motif functions as an oligomerization domain mediating self-association or association with other proteins bearing SCAN domains. These findings suggest that the SCAN domain plays an important role in the assembly and function of this newly defined subclass of transcriptional regulators. | |
| [PUBMED: 10567577] |   |
| Copyright © 2009, Tyers Lab, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved. |
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| BioGRID: A General Repository for Interaction Datasets. Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers. Nucleic Acids Res. Jan 1;34:D535-9. |