The BioGRID | PUBLICATION VIEW

	Mol. Microbiol. Jul (2008); 69(1):277-85
Caffeine extends yeast lifespan by targeting TORC1-
Wanke V, Cameroni E, Uotila A, Piccolis M, Urban J, Loewith R, De Virgilio C
Department of Microbiology and Molecular Medicine, University of Geneva Medical School CH-1211 Geneva, Switzerland-
Abstract: Dietary nutrient limitation -dietary restriction- is known to increase lifespan in a variety of organisms- Although the molecular events that couple dietary restriction to increased lifespan are not clear, studies of the model eukaryote Saccharomyces cerevisiae have implicated several nutrient-sensitive kinases, including the target of rapamycin complex 1 -TORC1-, Sch9, protein kinase A -PKA- and Rim15- We have recently demonstrated that TORC1 activates Sch9 by direct phosphorylation- We now show that Sch9 inhibits Rim15 also by direct phosphorylation- Treatment of yeast cells with the specific TORC1 inhibitor rapamycin or caffeine releases Rim15 from TORC1-Sch9-mediated inhibition and consequently increases lifespan- This kinase cascade appears to have been evolutionarily conserved, suggesting that caffeine may extend lifespan in other eukaryotes, including man-
[PUBMED: 18513215]