Search Organism: All OrganismsArabidopsis thalianaBacillus subtilis 168Bos taurusCaenorhabditis elegansCanis familiarisDanio rerioDrosophila melanogasterEquus caballusEscherichia coli K12Gallus gallusHomo sapiensMacaca mulattaMus musculusNematostella vectensisOryza sativaPan troglodytesRattus norvegicusSaccharomyces cerevisiaeSchizosaccharomyces pombeStrongylocentrotus purpuratusTakifugu rubripesXenopus laevis home help / support contribute downloads mirrors about us Mol. Genet. Genomics Jan (2008); 0: Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes- Cui Y, Ramnarain DB, Chiang YC, Ding LH, McMahon JS, Denis CL Department of Biochemistry and Molecular Biology, Rudman Hall, University of New Hampshire, Durham, New Hampshire, 03824, USA, yxc81@po-cwru-edu- Abstract: Of the nine known members of the CCR4-NOT complex, CCR4-CAF1 are most important in mRNA deadenylation whereas the NOT1-5 proteins are most critical for transcriptional repression- Whole genome microarray analysis using deletions in seven of the CCR4-NOT genes was used to determine the overall mRNA expression patterns that are affected by members of the yeast CCR4-NOT complex- Under glucose conditions, ccr4 and caf1 displayed a high degree of similarity in the manner that they affected gene expression- In contrast, the not deletions were similar in the way they affected genes, but showed no correlation with that of ccr4-caf1- A number of groups of functionally related proteins were specifically controlled by the CCR4-CAF1 or NOT modules- Importantly, the NOT proteins preferentially affected SAGA-controlled gene expression- Also, both the CCR4-CAF1 and NOT group of proteins shared much greater similarities in their effects on gene expression during the stress of glucose deprivation- BTT1, a member of the nascent polypeptide association complex that binds the ribosome, was shown to be a tenth member of the CCR4-NOT complex, interacting through CAF130- Microarray analysis indicated that BTT1 and CAF130 correlate very highly in their control of gene expression and preferentially repress genes involved in ribosome biogenesis- These results indicate that distinct portions of the CCR4-NOT complex control a number of different cellular processes- [PUBMED: 18214544] Copyright © 2009, Tyers Lab, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved. terms and conditions - privacy policy - Osprey Network Visualization System BioGRID: A General Repository for Interaction Datasets. Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers. Nucleic Acids Res. Jan 1;34:D535-9.