Search Organism: All OrganismsArabidopsis thalianaBacillus subtilis 168Bos taurusCaenorhabditis elegansCanis familiarisDanio rerioDrosophila melanogasterEquus caballusEscherichia coli K12Gallus gallusHomo sapiensMacaca mulattaMus musculusNematostella vectensisOryza sativaPan troglodytesRattus norvegicusSaccharomyces cerevisiaeSchizosaccharomyces pombeStrongylocentrotus purpuratusTakifugu rubripesXenopus laevis home help / support contribute downloads mirrors about us Genetics Feb (2008); 178(2):825-37 Multiple pathways influence mitochondrial inheritance in budding yeast- Frederick RL, Okamoto K, Shaw JM Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112- Abstract: Yeast mitochondria form a branched tubular network- Mitochondrial inheritance is tightly coupled with bud emergence, ensuring that daughter cells receive mitochondria from mother cells during division- Proteins reported to influence mitochondrial inheritance include the mitochondrial rho -Miro- GTPase Gem1p, Mmr1p, and Ypt11p- A synthetic genetic array -SGA- screen revealed interactions between gem1Delta and deletions of genes that affect mitochondrial function or inheritance, including mmr1Delta- Synthetic sickness of gem1Delta mmr1Delta double mutants correlated with defective mitochondrial inheritance by large buds- Additional studies demonstrated that GEM1, MMR1, and YPT11 each contribute to mitochondrial inheritance- Mitochondrial accumulation in buds caused by overexpression of either Mmr1p or Ypt11p did not depend on Gem1p, indicating these three proteins function independently- Physical linkage of mitochondria with the endoplasmic reticulum -ER- has led to speculation that distribution of these two organelles is coordinated- We show that yeast mitochondrial inheritance is not required for inheritance or spreading of cortical ER in the bud- Moreover, Ypt11p overexpression, but not Mmr1p overexpression, caused ER accumulation in the bud, revealing a potential role for Ypt11p in ER distribution- This study demonstrates that multiple pathways influence mitochondrial inheritance in yeast and that Miro GTPases have conserved roles in mitochondrial distribution- [PUBMED: 18245340] Copyright © 2009, Tyers Lab, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved. terms and conditions - privacy policy - Osprey Network Visualization System BioGRID: A General Repository for Interaction Datasets. Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers. Nucleic Acids Res. Jan 1;34:D535-9.