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| J. Biol. Chem. Nov (1996); 271(44):27197-200 | |
| A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor. | |
| Marcus SL, Winrow CJ, Capone JP, Rachubinski RA | |
| Department of Anatomy and Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. rrachubi@anat.med.ualberta.ca | |
| Abstract: Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, COUP-TFII stimulates transcription directly. A cellular factor, isolated by interaction cloning, bound COUP-TFII in vitro and allowed COUP-TFII to function as a transcriptional activator in mammalian cells. This factor is identical to a recently described ligand of the tyrosine kinase signaling molecule p56(lck), suggesting that it mediates cross-talk between mitogenic and nuclear hormone receptor signal transduction pathways. | |
| [PUBMED: 8910285] |   |
| Copyright © 2009, Tyers Lab, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved. |
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| BioGRID: A General Repository for Interaction Datasets. Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers. Nucleic Acids Res. Jan 1;34:D535-9. |