The BioGRID | PUBLICATION VIEW

	Cell Oct (2007); 131(1):121-35
Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches-
McClellan AJ, Xia Y, Deutschbauer AM, Davis RW, Gerstein M, Frydman J
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA-
Abstract: A comprehensive understanding of the cellular functions of the Hsp90 molecular chaperone has remained elusive- Although Hsp90 is essential, highly abundant under normal conditions, and further induced by environmental stress, only a limited number of Hsp90 "clients" have been identified- To define Hsp90 function, a panel of genome-wide chemical-genetic screens in Saccharomyces cerevisiae were combined with bioinformatic analyses- This approach identified several unanticipated functions of Hsp90 under normal conditions and in response to stress- Under normal growth conditions, Hsp90 plays a major role in various aspects of the secretory pathway and cellular transport; during environmental stress, Hsp90 is required for the cell cycle, meiosis, and cytokinesis- Importantly, biochemical and cell biological analyses validated several of these Hsp90-dependent functions, highlighting the potential of our integrated global approach to uncover chaperone functions in the cell-
[PUBMED: 17923092]