The BioGRID | PUBLICATION VIEW

	Nat. Cell Biol. Aug (2006); 8(8):849-54
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery-
Gauss R, Jarosch E, Sommer T, Hirsch C
Max-Delbruck Center for Molecular Medicine, Robert-Rossle-Str- 10, 13125 Berlin, Germany-
Abstract: A quality-control system surveys the lumen of the endoplasmic reticulum for terminally misfolded proteins- Polypeptides singled out by this system are ultimately degraded by the cytosolic ubiquitin-proteasome pathway- Key components of both the endoplasmic reticulum quality-control system and the degradation machinery have been identified, but a connection between the two systems has remained elusive- Here, we report an association between the endoplasmic reticulum quality-control lectin Yos9p and Hrd3p, a component of the ubiquitin-proteasome system that links these pathways- We identify designated regions in the luminal domain of Hrd3p that interact with Yos9p and the ubiquitin ligase Hrd1p- Binding of misfolded proteins occurs through Hrd3p, suggesting that Hrd3p recognises proteins that deviate from their native conformation, whereas Yos9p ensures that only terminally misfolded polypeptides are degraded-
[PUBMED: 16845381]