Departamento de Microbiologia II- Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain-
Abstract: Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite- Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification-