The BioGRID Database Seperator
Search
Organism:

FEBS Lett. Nov (1995); 374(3):317-22
Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase.
Domanski P, Yan H, Witte MM, Krolewski J, Colamonici OR
Department of Pathology, University of Tennessee, Memphis 88163, USA.
Abstract: The Jak kinases and Stat transcription factors play a major role in signaling of various cytokines including IFN alpha. In this report we show a ligand-independent interaction between Tyk-2 and Jak-1 kinases. We also demonstrate that the Tyk-2 kinase forms a homodimer that has the ability to undergo intermolecular tyrosine phosphorylation. The formation of the Tyk-2 homodimer is independent of both tyrosine phosphorylation and the presence of the tyrosine kinase domain.
[PUBMED: 7589562] Download Biogrid Interactions in a variety of formats including PSI FormatPUBMED
terms and conditions - privacy policy - Osprey Network Visualization System
BioGRID: A General Repository for Interaction Datasets.
Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
Nucleic Acids Res. Jan 1;34:D535-9.