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| Comp. Biochem. Physiol. B, Biochem. Mol. Biol. Sep (1998); 121(1):19-26 | |
| Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. | |
| Butler AA, Yakar S, Gewolb IH, Karas M, Okubo Y, LeRoith D | |
| Diabetes Branch, National Institutes of Health, Bethesda, MD 20892-1770, USA. | |
| Abstract: The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism. | |
| [PUBMED: 9972281] |   |
| Copyright © 2009, Tyers Lab, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved. |
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| BioGRID: A General Repository for Interaction Datasets. Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers. Nucleic Acids Res. Jan 1;34:D535-9. |