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FEBS Lett. Apr (1998); 426(2):229-32
HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice.
Bertaux F, Sharp AH, Ross CA, Lehrach H, Bates GP, Wanker E
Division of Medical and Molecular Genetics, UMDS, Guy's Hospital, London, UK.
Abstract: HAP1 (huntingtin associated protein) has previously been found to interact with huntingtin (htt) in a glutamine length dependent manner and has been proposed to play a role in the cell specific neurodegeneration observed in Huntington's disease (HD). We have isolated mouse HAP1 (hap1) and have shown that expression is not enriched in areas specifically affected in HD. We have used the yeast two hybrid system to demonstrate that htt amino acids 171-230 are necessary for the hap1-htt binding and that hapl does not interact with the transgene exon 1 protein in a transgenic model of HD.
[PUBMED: 9599014] Download Biogrid Interactions in a variety of formats including PSI FormatPUBMED
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Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
Nucleic Acids Res. Jan 1;34:D535-9.