The BioGRID | PUBLICATION VIEW

	J. Biol. Chem. Dec (1997); 272(49):30607-10
STAT3 acts as a co-activator of glucocorticoid receptor signaling.
Zhang Z, Jones S, Hagood JS, Fuentes NL, Fuller GM
Department of Cell Biology, Pulmonary Division, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Abstract: Interleukin-6 (IL-6) and glucocorticoids are important mediators of inflammatory and immunological responses. Glucocorticoids are known to synergistically enhance IL-6-mediated cellular responses. We now show that IL-6 also has a synergistic effect upon glucocorticoid signaling. In particular, IL-6-activated STAT3 associates with ligand-bound glucocorticoid receptor to form a transactivating/signaling complex, which can function through either an IL-6-responsive element or a glucocorticoid-responsive element. These findings reveal a new level of interaction between these two crucial signaling cascades and indicate that activated STAT3 can also act as a transcriptional co-activator without direct association with its DNA binding motif.
[PUBMED: 9388192]