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BioGRID | Network Layout for PAB1 for Saccharomyces cerevisiae
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PAB1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YER165W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Pab1p|Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with PAB1

PAB1 was identified with 140 protein interactions and 28 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 TIF4631
  • YGR162W
    		•  The BioGRID Database Seperator Tif4631p|Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Reconstituted Complex
    hit Wells SE (1998)
    bait Otero LJ (1999)
    bait Kessler SH (1998)
    bait Tarun SZ (1997)
    bait Tarun SZ (1996)
    Affinity Capture-Western
    bait Tarun SZ (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF4632
  • YGL049C
    		•  The BioGRID Database Seperator Tif4632p|Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Wells SE (1998)
    bait Otero LJ (1999)
    bait Kessler SH (1998)
    bait Tarun SZ (1997)
    bait Tarun SZ (1996)
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Affinity Capture-Western
    bait/hit Tarun SZ (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRM1
  • KAP124
  • XPO1
  • YGR218W
    		•  The BioGRID Database Seperator Crm1p|Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Hammell CM (2002)
    Affinity Capture-MS
    bait Brune C (2005)
    Affinity Capture-Western
    bait Brune C (2005)
    Co-localization
    hit Brune C (2005)
    Biochemical Activity
    hit Brune C (2005)
    Reconstituted Complex
    hit Brune C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUP35
  • GST1
  • PNM2
  • SAL3
  • YDR172W
    		•  The BioGRID Database Seperator Sup35p|Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Cosson B (2002)
    Two-hybrid
    bait Cosson B (2002)
    Affinity Capture-Western
    bait/hit Hosoda N (2003)
    bait Kobayashi T (2004)
    Dosage Lethality
    bait Kodama H (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARF1
  • YDL192W
    		•  The BioGRID Database Seperator ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p|Arf1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Trautwein M (2004)
    Two-hybrid
    bait Trautwein M (2004)
    Affinity Capture-Western
    bait Trautwein M (2004)
    Synthetic Lethality
    bait Trautwein M (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAT1
  • MRT1
  • YCR077C
    		•  The BioGRID Database Seperator Pat1p|Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Tharun S (2001)
    Affinity Capture-MS
    bait Gavin AC (2006)
    Synthetic Rescue
    hit Bonnerot C (2000)
    hit Wyers F (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEX67
  • YPL169C
    		•  The BioGRID Database Seperator Mex67p|Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Allen NP (2002)
    Co-purification
    hit Allen NP (2002)
    Affinity Capture-MS
    bait/hit Oeffinger M (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNA15
  • YGL044C
    		•  The BioGRID Database Seperator Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p|Rna15p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Amrani N (1997)
    Two-hybrid
    bait/hit Amrani N (1997)
    Co-fractionation
    bait Amrani N (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STO1
  • CBC1
  • CBP80
  • GCR3
  • YMR125W
    		•  The BioGRID Database Seperator Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80|Sto1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    bait/hit Oeffinger M (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCP1
  • YOL149W
    		•  The BioGRID Database Seperator Dcp1p|Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Vilela C (2000)
    Reconstituted Complex
    hit Vilela C (2000)
    Synthetic Growth Defect
    hit Simon E (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGN1
  • RBP1
  • RBP29
  • YIR001C
    		•  The BioGRID Database Seperator Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation|Sgn1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Winstall E (2000)
    Affinity Capture-MS
    bait Gavin AC (2006)
    Dosage Rescue
    hit Winstall E (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC33
  • TIF45
  • YOL139C
    		•  The BioGRID Database Seperator Cdc33p|Cytoplasmic mRNA cap binding protein; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p); protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Synthetic Lethality
    hit Tarun SZ (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PBP1
  • MRS16
  • YGR178C
    		•  The BioGRID Database Seperator Pbp1p|Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Mangus DA (1998)
    bait/hit Mangus DA (2004)
    Synthetic Rescue
    hit Mangus DA (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POP2
  • CAF1
  • YNR052C
    		•  The BioGRID Database Seperator Pop2p|RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Simon E (2007)
    Synthetic Lethality
    hit Ohn T (2007)
    hit Simon E (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB6
  • YML117W
    		•  The BioGRID Database Seperator Nab6p|Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP43
  • YGL120C
    		•  The BioGRID Database Seperator Prp43p|RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NRD1
  • YNL251C
    		•  The BioGRID Database Seperator Nrd1p|RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    bait/hit Vasiljeva L (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HCA4
  • DBP4
  • ECM24
  • YJL033W
    		•  The BioGRID Database Seperator Hca4p|Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YRA1
  • SHE11
  • YDR381W
    		•  The BioGRID Database Seperator Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function|Yra1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Kashyap AK (2005)
    bait/hit Oeffinger M (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP100
  • NSP100
  • YKL068W
    		•  The BioGRID Database Seperator Nup100p|Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Allen NP (2002)
    bait Allen NP (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SBP1
  • SSB1
  • SSBR1
  • YHL034C
    		•  The BioGRID Database Seperator Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11|Sbp1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP60
  • YAR002W
    		•  The BioGRID Database Seperator Nup60p|Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Denning D (2001)
    Affinity Capture-MS
    bait Allen NP (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA1
  • YG100
  • YAL005C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall|Ssa1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Horton LE (2001)
    Reconstituted Complex
    hit Horton LE (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCP160
  • YJL080C
    		•  The BioGRID Database Seperator Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins|Scp160p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lang BD (2001)
    bait Lang BD (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB3
  • HMD1
  • YPL190C
    		•  The BioGRID Database Seperator Nab3p|Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBP5
  • RAT8
  • YOR046C
    		•  The BioGRID Database Seperator Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination|Dbp5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gross T (2007)
    Dosage Rescue
    hit Gross T (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCR4
  • FUN27
  • NUT21
  • YAL021C
    		•  The BioGRID Database Seperator Ccr4p|Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Simon E (2007)
    Synthetic Lethality
    hit Simon E (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRP6
  • YOR001W
    		•  The BioGRID Database Seperator Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus|Rrp6p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Dunn EF (2005)
    hit Brune C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPB1
  • YCL054W
    		•  The BioGRID Database Seperator AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants|Spb1p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Pintard L (2000)
    hit Sachs AB (1989)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CWC2
  • NTC40
  • YDL209C
    		•  The BioGRID Database Seperator Cwc2p|Protein involved in pre-mRNA splicing, component of a complex containing Cef1p; interacts with Prp19p; contains an RNA recognition motif; has similarity to S. pombe Cwf2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR250C
  • YGR250C
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm|Ygr250cp; protein coding
    Gene Ontology: [View List]