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BioGRID | Network Layout for SPT15 for Saccharomyces cerevisiae
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SPT15

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: TBP1, BTF1, YER148W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 24 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SPT15

SPT15 was identified with 395 protein interactions and 73 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 TAF1
  • TAF130
  • TAF145
  • YGR274C
    		•  The BioGRID Database Seperator TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002) [3400]
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Fischbeck JA (2002) [4]
    hit Sanders SL (2000) [94]
    hit Sanders SL (2002) [483]
    hit Reese JC (2000) [15]
    hit Reese JC (1994) [1]
    bait/hit Poon D (1993) [9]
    bait/hit Poon D (1994) [13]
    bait/hit Poon D (1995) [11]
    bait Mencia M (2001) [7]
    bait Bai Y (1997) [6]
    hit Moqtaderi Z (1998) [4]
    bait Deluen C (2002) [22]
    hit Matangkasombut O (2000) [11]
    bait Kokubo T (1998) [6]
    hit Klebanow ER (1996) [13]
    bait Drysdale CM (1998) [23]
    bait Irvin JD (2006) [5]
    bait Garbett KA (2007) [15]
    hit van Werven FJ (2008) [22]
    bait Mischerikow N (2009) [32]
    Reconstituted Complex
    hit Bai Y (1997) [6]
    bait Banik U (2001) [1]
    bait Reese JC (2000) [15]
    hit Kou H (2003) [1]
    hit Kokubo T (1998) [6]
    Co-purification
    bait Sanders SL (2002) [14]
    Co-localization
    hit Shen WC (2003) [41]
    Protein-peptide
    bait Shooltz DD (2008) [1]
    Dosage Rescue
    bait Bai Y (1997) [6]
    Phenotypic Enhancement
    hit Chitikila C (2002) [1]
    Synthetic Lethality
    bait Kobayashi A (2001) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT1
  • LPF4
  • BUR3
  • YPL082C
    		•  The BioGRID Database Seperator Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002) [3400]
    hit Sanders SL (2002) [483]
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    bait van Werven FJ (2008) [22]
    bait Arnett DR (2008) [91]
    Affinity Capture-Western
    hit Lee TI (1998) [17]
    bait Sanders SL (2000) [94]
    bait Natarajan K (1998) [28]
    bait/hit Poon D (1994) [13]
    hit Adamkewicz JI (2001) [3]
    bait/hit van Werven FJ (2008) [22]
    bait Arnett DR (2008) [91]
    Reconstituted Complex
    bait Adamkewicz JI (2001) [3]
    bait Adamkewicz JI (2000) [1]
    bait Gumbs OH (2003) [1]
    bait Auble DT (1997) [1]
    hit Mohibullah N (2008) [10]
    Co-localization
    hit Andrau JC (2002) [1]
    hit Sprouse RO (2006) [1]
    Co-purification
    hit Wade PA (1996) [24]
    Co-fractionation
    hit Mohibullah N (2008) [10]
    Dosage Rescue
    hit Cang Y (1999) [5]
    bait Darst RP (2003) [1]
    bait Adamkewicz JI (2001) [3]
    bait Biswas D (2006) [25]
    Synthetic Lethality
    bait Cang Y (1999) [5]
    bait Biswas D (2006) [25]
    Synthetic Rescue
    bait Wang Z (2006) [27]
    bait Sprouse RO (2009) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF5
  • TAF90
  • YBR198C
    		•  The BioGRID Database Seperator Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    hit Gavin AC (2006) [7592]
    Affinity Capture-Western
    hit Lee TI (1998) [17]
    hit Fischbeck JA (2002) [4]
    hit Sanders SL (2000) [94]
    hit Reese JC (2000) [15]
    bait/hit Poon D (1993) [9]
    bait/hit Poon D (1994) [13]
    bait/hit Poon D (1995) [11]
    bait Durso RJ (2001) [16]
    bait Natarajan K (1998) [28]
    hit Moqtaderi Z (1998) [4]
    hit Klebanow ER (1996) [13]
    hit Romier C (2007) [2]
    Reconstituted Complex
    bait Warfield L (2004) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOA1
  • YOR194C
    		•  The BioGRID Database Seperator TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
    Gene Ontology: [View List]
    Co-crystal Structure
    bait Wang SM (2001) [6]
    bait Bleichenbacher M (2003) [1]
    hit Geiger JH (1996) [2]
    hit Tan S (1996) [2]
    Reconstituted Complex
    hit Kokubo T (1998) [6]
    hit Stargell LA (1996) [2]
    hit Kang JJ (1995) [3]
    bait Upadhyaya AB (2003) [2]
    hit Xie J (2000) [3]
    hit Biswas D (2004) [18]
    hit Solow SP (1999) [1]
    hit Kays AR (2000) [3]
    hit Colbert T (1998) [3]
    hit Mohibullah N (2008) [10]
    hit Sprouse RO (2009) [6]
    Dosage Rescue
    hit Liu Q (1999) [2]
    hit Biswas D (2004) [18]
    hit Biswas D (2005) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOA2
  • YKL058W
    		•  The BioGRID Database Seperator TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA
    Gene Ontology: [View List]
    Co-crystal Structure
    bait Wang SM (2001) [6]
    hit Geiger JH (1996) [2]
    hit Tan S (1996) [2]
    Reconstituted Complex
    hit Kokubo T (1998) [6]
    hit Stargell LA (1996) [2]
    hit Kang JJ (1995) [3]
    bait Upadhyaya AB (2003) [2]
    hit Xie J (2000) [3]
    hit Warfield L (2004) [13]
    hit Biswas D (2004) [18]
    hit Kays AR (2000) [3]
    hit Colbert T (1998) [3]
    hit Sprouse RO (2009) [6]
    Dosage Rescue
    hit Liu Q (1999) [2]
    bait/hit Biswas D (2004) [18]
    hit Biswas D (2005) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUA7
  • SOH4
  • YPR086W
    		•  The BioGRID Database Seperator Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
    Gene Ontology: [View List]
    Co-crystal Structure
    bait Wang SM (2001) [6]
    Reconstituted Complex
    bait Buratowski S (1993) [1]
    bait Stargell LA (1995) [1]
    hit Wade PA (1993) [1]
    hit Imbalzano AN (1994) [1]
    bait/hit Hodges JL (2005) [13]
    hit Kays AR (2000) [3]
    hit Jensen GJ (1998) [5]
    hit Sprouse RO (2009) [6]
    Co-purification
    hit Wade PA (1996) [24]
    Two-hybrid
    hit Chew BS (2007) [3]
    Far Western
    hit Chew BS (2007) [3]
    Dosage Rescue
    bait Buratowski RM (2002) [1]
    hit Biswas D (2005) [18]
    Synthetic Lethality
    hit Chou S (1997) [1]
    Synthetic Rescue
    hit Chew BS (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRF1
  • TDS4
  • PCF4
  • YGR246C
    		•  The BioGRID Database Seperator TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    hit Krogan NJ (2006) [7079]
    Affinity Capture-Western
    bait Sanders SL (2000) [94]
    hit Poon D (1993) [9]
    Co-crystal Structure
    hit Juo ZS (2003) [1]
    Reconstituted Complex
    hit Andrau JC (1999) [6]
    hit Roberts S (1996) [3]
    hit Kassavetis GA (1995) [3]
    hit Huet J (1994) [1]
    hit Colbert T (1998) [3]
    Two-hybrid
    hit Chaussivert N (1995) [5]
    Dosage Rescue
    bait Andrau JC (1999) [6]
    hit Buratowski S (1992) [1]
    hit Colbert T (1992) [1]
    Synthetic Rescue
    hit Cormack BP (1993) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF6
  • TAF60
  • YGL112C
    		•  The BioGRID Database Seperator Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Sanders SL (2000) [94]
    bait/hit Poon D (1993) [9]
    bait/hit Poon D (1994) [13]
    bait/hit Poon D (1995) [11]
    hit Moqtaderi Z (1998) [4]
    hit Matangkasombut O (2000) [11]
    hit Klebanow ER (1996) [13]
    Co-localization
    hit Shen WC (2003) [41]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF12
  • TAF61
  • TAF68
  • YDR145W
    		•  The BioGRID Database Seperator Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    hit Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Reese JC (2000) [15]
    hit Moqtaderi Z (1996) [8]
    hit Hall DB (2002) [8]
    hit Matangkasombut O (2000) [11]
    hit Romier C (2007) [2]
    Reconstituted Complex
    bait Reese JC (2000) [15]
    Co-localization
    hit Shen WC (2003) [41]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF11
  • TAF40
  • YML015C
    		•  The BioGRID Database Seperator TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    Affinity Capture-Western
    hit Sanders SL (2000) [94]
    hit Moqtaderi Z (1996) [8]
    hit Poon D (1994) [13]
    hit Poon D (1995) [11]
    hit Klebanow ER (1997) [6]
    hit Klebanow ER (1996) [13]
    hit Robinson MM (2005) [3]
    Reconstituted Complex
    hit Kraemer SM (2001) [5]
    Co-localization
    hit Shen WC (2003) [41]
    Dosage Rescue
    bait Komarnitsky PB (1999) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF10
  • TAF25
  • TAF23
  • YDR167W
    		•  The BioGRID Database Seperator Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    Affinity Capture-Western
    hit Fischbeck JA (2002) [4]
    bait/hit Sanders SL (2000) [94]
    hit Moqtaderi Z (1996) [8]
    hit Poon D (1994) [13]
    hit Poon D (1995) [11]
    bait Kirschner DB (2002) [15]
    bait Kirchner J (2001) [18]
    hit Klebanow ER (1996) [13]
    Co-localization
    hit Shen WC (2003) [41]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL4
  • GAL81
  • YPL248C
    		•  The BioGRID Database Seperator DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Melcher K (1995) [7]
    bait/hit Ansari AZ (2002) [5]
    bait/hit Ansari AZ (1998) [3]
    Reconstituted Complex
    bait Melcher K (1995) [7]
    hit Ansari AZ (1998) [3]
    bait Xie Y (2000) [1]
    bait Ding WV (1997) [1]
    bait Wu Y (1996) [3]
    Two-hybrid
    hit Bongards C (2003) [1]
    bait Lim MK (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT3
  • YDR392W
    		•  The BioGRID Database Seperator Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Affinity Capture-Western
    hit Lee TI (1998) [17]
    bait/hit Eisenmann DM (1992) [3]
    bait/hit Eisenmann DM (1994) [3]
    Co-localization
    hit Dudley AM (1999) [2]
    Reconstituted Complex
    hit Mohibullah N (2008) [10]
    Co-fractionation
    hit Mohibullah N (2008) [10]
    Synthetic Rescue
    hit Yu Y (2003) [10]
    hit Eisenmann DM (1992) [3]
    Phenotypic Suppression
    bait Laprade L (2007) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF14
  • SWP29
  • TFG3
  • ANC1
  • YPL129W
    		•  The BioGRID Database Seperator Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    hit Krogan NJ (2006) [7079]
    Affinity Capture-Western
    hit Sanders SL (2000) [94]
    hit Poon D (1994) [13]
    hit Poon D (1995) [11]
    hit Moqtaderi Z (1998) [4]
    hit Klebanow ER (1996) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF4
  • TAF48
  • MPT1
  • TSG2
  • YMR005W
    		•  The BioGRID Database Seperator TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    hit Krogan NJ (2006) [7079]
    Affinity Capture-Western
    bait/hit Sanders SL (2000) [94]
    hit Reese JC (2000) [15]
    hit van Werven FJ (2008) [22]
    Reconstituted Complex
    bait Warfield L (2004) [13]
    Co-localization
    hit Shen WC (2003) [41]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF2
  • TAF150
  • TSM1
  • YCR042C
    		•  The BioGRID Database Seperator TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    Affinity Capture-Western
    hit Sanders SL (2000) [94]
    bait/hit Poon D (1993) [9]
    bait/hit Poon D (1994) [13]
    bait/hit Poon D (1995) [11]
    hit Klebanow ER (1996) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF13
  • TAF19
  • FUN81
  • YML098W
    		•  The BioGRID Database Seperator TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    bait Auty R (2004) [19]
    Affinity Capture-Western
    hit Sanders SL (2000) [94]
    hit Moqtaderi Z (1996) [8]
    Co-localization
    hit Shen WC (2003) [41]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF7
  • TAF67
  • YMR227C
    		•  The BioGRID Database Seperator TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    hit Krogan NJ (2006) [7079]
    Affinity Capture-Western
    hit Sanders SL (2000) [94]
    hit Moqtaderi Z (1996) [8]
    Co-localization
    hit Shen WC (2003) [41]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAP114
  • YGL241W
    		•  The BioGRID Database Seperator Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    Affinity Capture-Western
    bait/hit Pemberton LF (1999) [3]
    hit Morehouse H (1999) [3]
    Reconstituted Complex
    hit Hodges JL (2005) [13]
    Dosage Rescue
    hit Morehouse H (1999) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUR6
  • NCB1
  • YER159C
    		•  The BioGRID Database Seperator Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Lee TI (1998) [17]
    bait/hit van Werven FJ (2008) [22]
    Co-localization
    bait van Werven FJ (2008) [22]
    Reconstituted Complex
    hit Sprouse RO (2009) [6]
    Dosage Rescue
    hit Cang Y (1999) [5]
    Synthetic Lethality
    bait Cang Y (1999) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF9
  • TAF17
  • YMR236W
    		•  The BioGRID Database Seperator Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    Affinity Capture-Western
    hit Sanders SL (2000) [94]
    hit Moqtaderi Z (1996) [8]
    Co-localization
    hit Shen WC (2003) [41]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT15
  • TBP1
  • BTF1
  • YER148W
    		•  The BioGRID Database Seperator TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2000) [94]
    Two-hybrid
    hit Adams CA (2004) [2]
    Affinity Capture-Western
    hit Adams CA (2004) [2]
    Co-fractionation
    hit Daugherty MA (1999) [1]
    Reconstituted Complex
    hit Gupta S (2007) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT8
  • YLR055C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Reconstituted Complex
    bait/hit Warfield L (2004) [13]
    hit Sermwittayawong D (2006) [16]
    hit Mohibullah N (2008) [10]
    Phenotypic Suppression
    bait Laprade L (2007) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRN9
  • YMR270C
    		•  The BioGRID Database Seperator Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Steffan JS (1998) [4]
    hit Steffan JS (1996) [7]
    Two-hybrid
    bait/hit Steffan JS (1998) [4]
    bait/hit Steffan JS (1996) [7]
    Dosage Rescue
    bait Aprikian P (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCB2
  • YDR1
  • YDR397C
    		•  The BioGRID Database Seperator Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit van Werven FJ (2008) [22]
    Co-localization
    bait van Werven FJ (2008) [22]
    Reconstituted Complex
    hit Mohibullah N (2008) [10]
    hit Sprouse RO (2009) [6]
    Dosage Rescue
    hit Cang Y (1999) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF8
  • TAF65
  • YML114C
    		•  The BioGRID Database Seperator TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    Affinity Capture-Western
    bait/hit Sanders SL (2000) [94]
    Co-localization
    hit Shen WC (2003) [41]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF3
  • TAF47
  • YPL011C
    		•  The BioGRID Database Seperator TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    bait/hit Sanders SL (2000) [94]
    hit Krogan NJ (2006) [7079]
    Affinity Capture-Western
    hit Sanders SL (2000) [94]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STD1
  • SFS3
  • MSN3
  • YOR047C
    		•  The BioGRID Database Seperator Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Tillman TS (1995) [2]
    Two-hybrid
    bait Tillman TS (1995) [2]
    Dosage Rescue
    hit Zhang X (1998) [1]
    hit Ganster RW (1993) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT20
  • ADA5
  • YOL148C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Co-localization
    hit Dudley AM (1999) [2]
    Affinity Capture-Western
    bait Roberts SM (1997) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT7
  • GIT2
  • YBR081C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Affinity Capture-Western
    bait Mohibullah N (2008) [10]
    Co-localization
    hit Mohibullah N (2008) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO21
  • SUA8
  • RPB220
  • RPB1
  • YDL140C
    		•  The BioGRID Database Seperator RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Thompson CM (1993) [12]
    Co-localization
    bait Kaplan CD (2003) [1]
    Affinity Capture-Western
    bait Liu Y (2009) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NGG1
  • ADA3
  • SWI7
  • YDR176W
    		•  The BioGRID Database Seperator Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Affinity Capture-Western
    bait Drysdale CM (1998) [23]
    Reconstituted Complex
    hit Saleh A (1997) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN5
  • SWI9
  • ADA4
  • YGR252W
    		•  The BioGRID Database Seperator Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Synthetic Growth Defect
    bait Yu Y (2003) [10]
    Synthetic Lethality
    hit Biswas D (2004) [18]
    Dosage Rescue
    bait Biswas D (2004) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BDP1
  • TFC5
  • YNL039W
    		•  The BioGRID Database Seperator Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Roberts S (1996) [3]
    hit Kassavetis GA (1995) [3]
    Dosage Rescue
    bait Ishiguro A (2002) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVB2
  • TIH2
  • TIP49B
  • TIP49
  • YPL235W
    		•  The BioGRID Database Seperator Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Ohdate H (2003) [5]
    Reconstituted Complex
    hit Ohdate H (2003) [5]
    Synthetic Lethality
    hit Ohdate H (2003) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BDF1
  • YLR399C
    		•  The BioGRID Database Seperator Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Affinity Capture-Western
    bait/hit Matangkasombut O (2000) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MBF1
  • SUF13
  • YOR298C-A
    		•  The BioGRID Database Seperator Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Takemaru K (1998) [5]
    Reconstituted Complex
    bait Takemaru K (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKB2
  • YOR039W
    		•  The BioGRID Database Seperator Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Affinity Capture-Western
    bait Ghavidel A (2001) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVB1
  • TIP49A
  • TIP48
  • TIH1
  • YDR190C
    		•  The BioGRID Database Seperator Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Ohdate H (2003) [5]
    Reconstituted Complex
    hit Ohdate H (2003) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HFI1
  • GAN1
  • SRM12
  • SUP110
  • YPL254W
    		•  The BioGRID Database Seperator Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Reconstituted Complex
    hit Sermwittayawong D (2006) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS1
  • GRD1
  • LAM1
  • VPL1
  • YKR001C
    		•  The BioGRID Database Seperator Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKB1
  • YGL019W
    		•  The BioGRID Database Seperator Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ghavidel A (2001) [6]
    Reconstituted Complex
    bait Ghavidel A (2001) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADA2
  • SWI8
  • YDR448W
    		•  The BioGRID Database Seperator Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Affinity Capture-Western
    hit Barlev NA (1995) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKA2
  • YOR29-12
  • YOR061W
    		•  The BioGRID Database Seperator Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ghavidel A (2001) [6]
    Biochemical Activity
    bait Ghavidel A (2001) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB5
  • MED18
  • YGR104C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Zaman Z (2001) [10]
    hit Lariviere L (2006) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO4
  • YFR034C
    		•  The BioGRID Database Seperator Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Magbanua JP (1997) [7]
    Affinity Capture-Western
    bait Sun L (2002) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC73
  • YLR418C
    		•  The BioGRID Database Seperator Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance
    Gene Ontology: [View List]
    Two-hybrid
    bait Kerkmann K (2001) [8]
    Co-fractionation
    bait Shi X (1997) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT6
  • SCB68
  • CIM3
  • SUG1
  • YGL048C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Swaffield JC (1995) [3]
    Affinity Capture-Western
    hit Sun L (2002) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC1
  • YGR056W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Affinity Capture-Western
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC2
  • YLR357W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    Affinity Capture-Western
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRN6
  • YBL014C
    		•  The BioGRID Database Seperator Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn7p and TATA-binding protein
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Steffan JS (1996) [7]
    Two-hybrid
    hit Steffan JS (1996) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB2
  • HRS2
  • MED20
  • YHR041C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
    Gene Ontology: [View List]
    Co-purification
    bait Yudkovsky N (2000) [10]
    Affinity Capture-Western
    hit Lariviere L (2006) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCR4
  • FUN27
  • NUT21
  • YAL021C
    		•  The BioGRID Database Seperator Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Biswas D (2006) [25]
    Dosage Rescue
    bait Biswas D (2006) [25]
    Synthetic Rescue
    bait Badarinarayana V (2000) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT16
  • CDC68
  • SSF1
  • YGL207W
    		•  The BioGRID Database Seperator Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Biswas D (2005) [18]
    Synthetic Growth Defect
    hit Biswas D (2005) [18]
    Dosage Rescue
    bait Biswas D (2005) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC39
  • ROS1
  • NOT1
  • SMD6
  • YCR093W
    		•  The BioGRID Database Seperator Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Lee TI (1998) [17]
    Synthetic Rescue
    bait Collart MA (1996) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASF1
  • CIA1
  • YJL115W
    		•  The BioGRID Database Seperator Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Chimura T (2002) [13]
    Dosage Rescue
    bait Chimura T (2002) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Zhao R (2005) [489]
    Synthetic Growth Defect
    bait McClellan AJ (2007) [1419]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    Synthetic Growth Defect
    bait McClellan AJ (2007) [1419]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMO1
  • HSM2
  • YDR174W
    		•  The BioGRID Database Seperator Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Kasahara K (2008) [9]
    Synthetic Growth Defect
    hit Kasahara K (2008) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTF1
  • CSL3
  • YGL244W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Stolinski LA (1997) [1]
    hit Warner MH (2007) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF2
  • SWI2
  • GAM1
  • TYE3
  • YOR290C
    		•  The BioGRID Database Seperator Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Biswas D (2004) [18]
    Dosage Rescue
    bait Biswas D (2004) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAA1
  • YDR071C
    		•  The BioGRID Database Seperator Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Liu B (2005) [6]
    Phenotypic Suppression
    hit Liu B (2005) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NHP6A
  • YPR052C
    		•  The BioGRID Database Seperator High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
    Gene Ontology: [View List]
    Dosage Rescue
    hit Biswas D (2004) [18]
    bait/hit Biswas D (2006) [25]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB7
  • YDR404C
    		•  The BioGRID Database Seperator RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Jensen GJ (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MED8
  • YBR193C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Lariviere L (2006) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL20A
  • RPL18A2
  • YMR242C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB4
  • CTF15
  • YJL140W
    		•  The BioGRID Database Seperator RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Jensen GJ (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KSS1
  • YGR040W
    		•  The BioGRID Database Seperator Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO2
  • BAS2
  • GRF10
  • YDL106C
    		•  The BioGRID Database Seperator Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Magbanua JP (1997) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAP1
  • GRF1
  • TUF1
  • TBA1
  • YNL216W
    		•  The BioGRID Database Seperator DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Tomar RS (2008) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB3
  • YIL021W
    		•  The BioGRID Database Seperator RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Tardiff DF (2007) [46]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF1
  • YBR009C
    		•  The BioGRID Database Seperator One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL11
  • SPT13
  • ABE1
  • MED15
  • YOL051W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
    Gene Ontology: [View List]
    Two-hybrid
    bait Lim MK (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRV2
  • CAP
  • YNL138W
    		•  The BioGRID Database Seperator CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN4
  • ARG9
  • AAS3
  • YEL009C
    		•  The BioGRID Database Seperator Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Melcher K (1995) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB4
  • MED17
  • YER022W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Co-purification
    bait Thompson CM (1993) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADR1
  • YDR216W
    		•  The BioGRID Database Seperator Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Komarnitsky PB (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSE1
  • KAP121
  • YMR308C
    		•  The BioGRID Database Seperator Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Pemberton LF (1999) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BFR1
  • YOR198C
    		•  The BioGRID Database Seperator Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Alexander DE (2004) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFB2
  • YPL122C
    		•  The BioGRID Database Seperator Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Sun L (2002) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFB4
  • YPR056W
    		•  The BioGRID Database Seperator Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p
    Gene Ontology: [View List]
    Co-purification
    bait Wade PA (1996) [24]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • SUN1
  • MCB1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
    Gene Ontology: [View List]
    Co-fractionation
    bait Fujimuro M (1998) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAP1
  • YKR048C
    		•  The BioGRID Database Seperator Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YEF3
  • TEF3
  • YLR249W
    		•  The BioGRID Database Seperator Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJL123C
  • YJL123C
    		•  The BioGRID Database Seperator Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); YJL123C is a non-essential gene
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD23
  • YEL037C
    		•  The BioGRID Database Seperator Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Sun L (2002) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEX19
  • PAS12
  • YDL065C
    		•  The BioGRID Database Seperator Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRL1
  • YHR036W
    		•  The BioGRID Database Seperator Essential nuclear envelope integral membrane protein identified as a suppressor of a cold-sensitive mutant of CRM1, a karyopherin; homologous to and interacts with Brr6p, which is a nuclear envelope protein involved in nuclear export
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Adam M (2001) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIM1
  • CDH1
  • YPL266W
    		•  The BioGRID Database Seperator Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MGM101
  • MGM9
  • YJR144W
    		•  The BioGRID Database Seperator Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NHP2
  • YDL208W
    		•  The BioGRID Database Seperator Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAK5
  • YBR142W
    		•  The BioGRID Database Seperator Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTB2
  • YBL002W
    		•  The BioGRID Database Seperator One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTB1
  • SPT12
  • YDR224C
    		•  The BioGRID Database Seperator One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOP58
  • NOP5
  • YOR310C
    		•  The BioGRID Database Seperator Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOT5
  • YPR072W
    		•  The BioGRID Database Seperator Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Badarinarayana V (2000) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL9A
  • YGL147C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL23B
  • YER117W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL23A
  • YBL087C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPC53
  • RPC4
  • YDL150W
    		•  The BioGRID Database Seperator RNA polymerase III subunit C53
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA2
  • H2A2
  • YBL003C
    		•  The BioGRID Database Seperator One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA1
  • H2A1
  • SPT11
  • YDR225W
    		•  The BioGRID Database Seperator One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IST3
  • SNU17
  • YIR005W
    		•  The BioGRID Database Seperator Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT5
  • YTA1
  • YOR117W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN9
  • YDR427W
    		•  The BioGRID Database Seperator Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PFK2
  • YMR205C
    		•  The BioGRID Database Seperator Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP7
  • SWP61
  • RSC11
  • YPR034W
    		•  The BioGRID Database Seperator Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BNI1
  • SHE5
  • PPF3
  • YNL271C
    		•  The BioGRID Database Seperator Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOT1
  • YMR172W
    		•  The BioGRID Database Seperator Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIG1
  • RST1
  • YPL049C
    		•  The BioGRID Database Seperator Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBP8
  • YHR169W
    		•  The BioGRID Database Seperator Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit
    Gene Ontology: [View List]