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BioGRID | Network Layout for GLO3 for Saccharomyces cerevisiae
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GLO3

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YER122C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p|Glo3p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 7 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with GLO3

GLO3 was identified with 43 protein interactions and 45 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 ARF1
  • YDL192W
    		•  The BioGRID Database Seperator ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p|Arf1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Poon PP (1999)
    Co-purification
    bait Trautwein M (2006)
    Two-hybrid
    bait Yahara N (2006)
    Synthetic Lethality
    hit Poon PP (1999)
    Synthetic Growth Defect
    bait Zhang CJ (2003)
    Dosage Rescue
    bait Yahara N (2006)
    bait Zhang CJ (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC21
  • YNL287W
    		•  The BioGRID Database Seperator Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo|Sec21p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Collins SR (2007)
    Affinity Capture-Western
    bait Lewis SM (2004)
    Synthetic Lethality
    bait Poon PP (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC26
  • YDR238C
    		•  The BioGRID Database Seperator Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)|Sec26p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCS1
  • YDL226C
    		•  The BioGRID Database Seperator ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p|Gcs1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Zhang CJ (2003)
    bait Robinson M (2006)
    Dosage Rescue
    hit Lewis SM (2004)
    bait Wong TA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COP1
  • RET1
  • SEC33
  • SOO1
  • YDL145C
    		•  The BioGRID Database Seperator Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway|Cop1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC27
  • YGL137W
    		•  The BioGRID Database Seperator Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP|Sec27p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARL1
  • DLP2
  • YBR164C
    		•  The BioGRID Database Seperator Arl1p|Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Liu YW (2005)
    Synthetic Lethality
    bait Tong AH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC73
  • YLR418C
    		•  The BioGRID Database Seperator Cdc73p|Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Krogan NJ (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE20
  • YHL007C
    		•  The BioGRID Database Seperator Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases|Ste20p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWE1
  • WEE1
  • YJL187C
    		•  The BioGRID Database Seperator Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate|Swe1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF1
  • CAT1
  • CCR1
  • GLC2
  • YDR477W
    		•  The BioGRID Database Seperator AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis|Snf1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKM1
  • YOL113W
    		•  The BioGRID Database Seperator Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth|Skm1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPK1
  • PKA1
  • SRA3
  • YJL164C
    		•  The BioGRID Database Seperator Tpk1p|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RCK2
  • CLK1
  • CMK3
  • YLR248W
    		•  The BioGRID Database Seperator Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations|Rck2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COPB2
  • beta -COP
  • EG9276
    		•  The BioGRID Database Seperator betaprime-COP|coatomer binding complex, beta prime subunit; coatomer protein complex, subunit beta 2 (beta prime)
    Gene Ontology: [View List]
    Two-hybrid
    hit Eugster A (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO80
  • AGS3
  • TUP7
  • VAC5
  • YOL001W
    		•  The BioGRID Database Seperator Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance|Pho80p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COPG
  • COPG1
  • FLJ21068
  • EG22820
    		•  The BioGRID Database Seperator coat protein gamma-cop|coatomer protein complex, subunit gamma 1; coatomer protein complex, subunit gamma
    Gene Ontology: [View List]
    Two-hybrid
    hit Eugster A (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RBD2
  • YPL246C
    		•  The BioGRID Database Seperator Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p|Rbd2p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPL141C
  • YPL141C
    		•  The BioGRID Database Seperator Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene|Ypl141cp; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK2
  • YNL154C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p|Yck2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK1
  • CKI2
  • YHR135C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p|Yck1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARF1
  • EG375
    		•  The BioGRID Database Seperator ADP-ribosylation factor 1
    Gene Ontology: [View List]
    Two-hybrid
    hit Eugster A (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BCK1
  • LAS3
  • SAP3
  • SLK1
  • YJL095W
    		•  The BioGRID Database Seperator Bck1p|Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FUS3
  • DAC2
  • YBL016W
    		•  The BioGRID Database Seperator Fus3p|Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivatd by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG1
  • APG1
  • AUT3
  • CVT10
  • YGL180W
    		•  The BioGRID Database Seperator Atg1p|Protein serine/threonine kinase, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LYS20
  • YDL182W
    		•  The BioGRID Database Seperator Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p|Lys20p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2
  • STK2
  • YJR059W
    		•  The BioGRID Database Seperator Ptk2p|Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARF2
  • YDL137W
    		•  The BioGRID Database Seperator ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p|Arf2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Poon PP (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSL1
  • NIK1
  • YKL101W
    		•  The BioGRID Database Seperator Hsl1p|Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKA1
  • YIL035C
    		•  The BioGRID Database Seperator Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases|Cka1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRK1
  • PAK1
  • YIL095W
    		•  The BioGRID Database Seperator Prk1p|Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRE1
  • ERN1
  • YHR079C
    		•  The BioGRID Database Seperator Ire1p|Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCL1
  • HCS26
  • YNL289W
    		•  The BioGRID Database Seperator Pcl1p|Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCK1
  • YPK1
  • YNL307C
    		•  The BioGRID Database Seperator Mck1p|Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KSP1
  • YHR082C
    		•  The BioGRID Database Seperator Ksp1p|Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIN2
  • YLR096W
    		•  The BioGRID Database Seperator Kin2p|Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD53
  • LSD1
  • MEC2
  • SPK1
  • YPL153C
    		•  The BioGRID Database Seperator Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication|Rad53p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC66
  • HSS1
  • SEC71
  • YBR171W
    		•  The BioGRID Database Seperator Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER|Sec66p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWA2
  • AUX1
  • BUD24
  • YDR320C
    		•  The BioGRID Database Seperator Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles|Swa2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERV14
  • YGL054C
    		•  The BioGRID Database Seperator Erv14p|Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMA1
  • YGL008C
    		•  The BioGRID Database Seperator Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases|Pma1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERP2