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BioGRID | Network Layout for BOI2 for Saccharomyces cerevisiae
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BOI2

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: BEB1, YER114C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 13 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with BOI2

BOI2 was identified with 37 protein interactions and 47 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 BEM1
  • SRO1
  • YBR200W
    		•  The BioGRID Database Seperator Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait McCusker D (2007) [12]
    Two-hybrid
    bait/hit Drees BL (2001) [205]
    bait Matsui Y (1996) [7]
    bait Tonikian R (2009) [751]
    Reconstituted Complex
    bait Bender L (1996) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC24
  • CLS4
  • YAL041W
    		•  The BioGRID Database Seperator Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Gavin AC (2006) [7592]
    bait McCusker D (2007) [12]
    Affinity Capture-Western
    bait McCusker D (2007) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DSE1
  • YER124C
    		•  The BioGRID Database Seperator Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
    Gene Ontology: [View List]
    Two-hybrid
    hit Drees BL (2001) [205]
    hit Tong AH (2002) [250]
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BOI1
  • BOB1
  • GIN7
  • YBL085W
    		•  The BioGRID Database Seperator Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Matsui Y (1996) [7]
    bait Bender L (1996) [9]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Kozubowski L (2008) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZDS2
  • CES4
  • YML109W
    		•  The BioGRID Database Seperator Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p
    Gene Ontology: [View List]
    Two-hybrid
    hit Drees BL (2001) [205]
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JNM1
  • INS1
  • PAC3
  • YMR294W
    		•  The BioGRID Database Seperator Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    bait Schoener D (2008) [268]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NIP100
  • PAC13
  • YPL174C
    		•  The BioGRID Database Seperator Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP1
  • ACT5
  • YHR129C
    		•  The BioGRID Database Seperator Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RHO4
  • YKR055W
    		•  The BioGRID Database Seperator Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
    Gene Ontology: [View List]
    Dosage Rescue
    hit Matsui Y (1996) [7]
    hit Bender L (1996) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RHO3
  • YIL118W
    		•  The BioGRID Database Seperator Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
    Gene Ontology: [View List]
    Dosage Rescue
    hit Matsui Y (1996) [7]
    hit Bender L (1996) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DYN1
  • PAC6
  • DHC1
  • YKR054C
    		•  The BioGRID Database Seperator Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAC11
  • YDR488C
    		•  The BioGRID Database Seperator Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHO1
  • SSU81
  • YER118C
    		•  The BioGRID Database Seperator Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
    Gene Ontology: [View List]
    Two-hybrid
    bait Tong AH (2002) [250]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AFR1
  • YDR085C
    		•  The BioGRID Database Seperator Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YMR124W
  • YMR124W
    		•  The BioGRID Database Seperator Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAP6
  • HAL7
  • YDR259C
    		•  The BioGRID Database Seperator Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC42
  • YLR229C
    		•  The BioGRID Database Seperator Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
    Gene Ontology: [View List]
    Two-hybrid
    bait Drees BL (2001) [205]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSB1
  • YOR188W
    		•  The BioGRID Database Seperator Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4
    Gene Ontology: [View List]
    Two-hybrid
    hit Drees BL (2001) [205]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIR1
  • PIP1
  • YER032W
    		•  The BioGRID Database Seperator Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLA4
  • ERC10
  • YNL298W
    		•  The BioGRID Database Seperator Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
    Gene Ontology: [View List]
    Two-hybrid
    hit Drees BL (2001) [205]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRS6
  • MSI4
  • YOR370C
    		•  The BioGRID Database Seperator Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
    Gene Ontology: [View List]
    Two-hybrid
    hit Drees BL (2001) [205]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET31
  • YPL038W
    		•  The BioGRID Database Seperator Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32p
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE20
  • YHL007C
    		•  The BioGRID Database Seperator Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Drees BL (2001) [205]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NIS1
  • JIP1
  • YNL078W
    		•  The BioGRID Database Seperator Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAM7
  • MOF4
  • UPF1
  • IFS2
  • YMR080C
    		•  The BioGRID Database Seperator ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIG2
  • RST2
  • YDR480W
    		•  The BioGRID Database Seperator Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IML1
  • YJR138W
    		•  The BioGRID Database Seperator Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YER158C
  • YER158C
    		•  The BioGRID Database Seperator Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TID3
  • NDC80
  • HEC1
  • YIL144W
    		•  The BioGRID Database Seperator Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIG1
  • RST1
  • YPL049C
    		•  The BioGRID Database Seperator Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC55
  • YGL190C
    		•  The BioGRID Database Seperator Non-essential regulatory subunit B of protein phosphatase 2A, which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at the bud neck and at the bud tip
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AIM44
  • YPL158C
    		•  The BioGRID Database Seperator Protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation) and reduced growth rate in minimal glycerol media
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YMR244W
  • YMR244W
    		•  The BioGRID Database Seperator Putative protein of unknown function
    Gene Ontology: [View List]
    Two-hybrid
    hit Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI6
  • PSL8
  • SDS11
  • YLR182W
    		•  The BioGRID Database Seperator Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APC9
  • YLR102C
    		•  The BioGRID Database Seperator Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
    Gene Ontology: [View List]
    Positive Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LDB18
  • YLL049W
    		•  The BioGRID Database Seperator Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKL133C
  • YKL133C
    		•  The BioGRID Database Seperator Putative protein of unknown function
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DYN3
  • YMR299C
    		•  The BioGRID Database Seperator Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGL010W
  • YGL010W
    		•  The BioGRID Database Seperator Putative protein of unknown function; YGL010W is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC15
  • YGL233W
    		•  The BioGRID Database Seperator Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EXO70
  • YJL085W
    		•  The BioGRID Database Seperator Essential 70kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPP2B
  • RPL45
  • YPA1
  • YDR382W
    		•  The BioGRID Database Seperator Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBA3
  • YPR066W
    		•  The BioGRID Database Seperator Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBP1
  • LPH8
  • YPL119C
    		•  The BioGRID Database Seperator Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOD5
  • YOR274W
    		•  The BioGRID Database Seperator Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAC1
  • YOR269W
    		•  The BioGRID Database Seperator Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRE11
  • XRS4
  • NGS1
  • RAD58
  • YMR224C
    		•  The BioGRID Database Seperator Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Norden C (2006) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTC1
  • CWH47
  • KCS2
  • TPD1
  • YDL006W
    		•  The BioGRID Database Seperator Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NBP2
  • YDR162C
    		•  The BioGRID Database Seperator Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAM1
  • SGP2
  • SCG2
  • DPR1
  • YDL090C
    		•  The BioGRID Database Seperator Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKU70
  • HDF1
  • NES24
  • YMR284W
    		•  The BioGRID Database Seperator Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Norden C (2006) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSS4
  • YDR208W
    		•  The BioGRID Database Seperator Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Audhya A (2004) [33]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTC2
  • YER089C
    		•  The BioGRID Database Seperator Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP3
  • YER151C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSR1
  • BUD1
  • YGR152C
    		•  The BioGRID Database Seperator GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Kozubowski L (2008) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIT2
  • YBR270C
    		•  The BioGRID Database Seperator Bit2p
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLC7
  • CID1
  • DIS2
  • YER133W
    		•  The BioGRID Database Seperator Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Logan MR (2008) [224]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PLC1
  • YPL268W
    		•  The BioGRID Database Seperator Phosphoinositide-specific phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in kinetochore function and pseudohyphal differentiation
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELM1
  • LDB9
  • YKL048C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUM1
  • PAC12
  • YDR150W
    		•  The BioGRID Database Seperator Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.