The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for BIM1 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

BIM1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YEB1, YER016W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 18 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with BIM1

BIM1 was identified with 57 protein interactions and 675 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 KAR9
  • YPL269W
    		•  The BioGRID Database Seperator Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Miller RK (2000) [5]
    bait Liakopoulos D (2003) [4]
    bait Korinek WS (2000) [2]
    bait/hit Lee L (2000) [3]
    bait Cuschieri L (2006) [9]
    bait Moore JK (2007) [3]
    Two-hybrid
    bait Yin H (2000) [4]
    bait Miller RK (2000) [5]
    bait Korinek WS (2000) [2]
    bait Moore JK (2006) [6]
    bait Moore JK (2007) [3]
    Co-fractionation
    bait Lee L (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIK1
  • ARM5
  • PAC14
  • YCL029C
    		•  The BioGRID Database Seperator Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001) [1585]
    bait/hit Wolyniak MJ (2006) [20]
    Affinity Capture-Western
    bait/hit Wolyniak MJ (2006) [20]
    Reconstituted Complex
    bait Wolyniak MJ (2006) [20]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Schwartz K (1997) [9]
    hit Pan X (2004) [323]
    Phenotypic Enhancement
    bait Wolyniak MJ (2006) [20]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAD2
  • YJL030W
    		•  The BioGRID Database Seperator Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    bait Lee MS (2004) [41]
    hit Pan X (2004) [323]
    bait Daniel JA (2006) [214]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STU2
  • YLR045C
    		•  The BioGRID Database Seperator Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
    Gene Ontology: [View List]
    Two-hybrid
    bait Chen XP (1998) [8]
    bait/hit Wolyniak MJ (2006) [20]
    bait Wong J (2007) [604]
    Affinity Capture-Western
    hit Wolyniak MJ (2006) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUO1
  • YGL061C
    		•  The BioGRID Database Seperator Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001) [1585]
    bait Uetz P (2000) [875]
    bait Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCC1
  • YCL016C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF8
  • YHR191C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    bait Mayer ML (2004) [26]
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BFA1
  • IBD1
  • YJR053W
    		•  The BioGRID Database Seperator Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pereira G (2000) [11]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Kim J (2008) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAD1
  • YGL086W
    		•  The BioGRID Database Seperator Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    bait Lee MS (2004) [41]
    hit Pan X (2004) [323]
    bait Daniel JA (2006) [214]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DYN1
  • PAC6
  • DHC1
  • YKR054C
    		•  The BioGRID Database Seperator Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Muhua L (1998) [4]
    hit Pan X (2004) [323]
    Dosage Rescue
    bait Cuschieri L (2006) [9]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JNM1
  • INS1
  • PAC3
  • YMR294W
    		•  The BioGRID Database Seperator Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Muhua L (1998) [4]
    bait Schoener D (2008) [268]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait Dixon SJ (2008) [1412]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSM3
  • YMR048W
    		•  The BioGRID Database Seperator Protein required for accurate chromosome segregation during meiosis
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IPL1
  • PAC15
  • YPL209C
    		•  The BioGRID Database Seperator Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Wong J (2007) [604]
    Biochemical Activity
    bait Zimniak T (2009) [3]
    Reconstituted Complex
    hit Zimniak T (2009) [3]
    Synthetic Lethality
    bait Ng TM (2009) [25]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAC1
  • YOR269W
    		•  The BioGRID Database Seperator Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    bait Lee WL (2003) [2]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIP3
  • YGL216W
    		•  The BioGRID Database Seperator Kinesin-related motor protein involved in mitotic spindle positioning
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF18
  • CHL12
  • YMR078C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUB3
  • YOR026W
    		•  The BioGRID Database Seperator Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Schwartz K (1997) [9]
    hit Pan X (2004) [323]
    bait Daniel JA (2006) [214]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASE1
  • YOR29-09
  • YOR058C
    		•  The BioGRID Database Seperator Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM3
  • PFD4
  • YNL153C
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUB2
  • PAC7
  • YMR055C
    		•  The BioGRID Database Seperator Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pereira G (2000) [11]
    hit Pan X (2004) [323]
    Synthetic Growth Defect
    hit Pereira G (2000) [11]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAD3
  • YJL013C
    		•  The BioGRID Database Seperator Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    bait Lee MS (2004) [41]
    hit Pan X (2004) [323]
    bait Daniel JA (2006) [214]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUM1
  • PAC12
  • YDR150W
    		•  The BioGRID Database Seperator Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Schwartz K (1997) [9]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC5
  • AOR1
  • YBR231C
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP1
  • ACT5
  • YHR129C
    		•  The BioGRID Database Seperator Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    bait Schoener D (2008) [268]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHL4
  • MCM17
  • CTF17
  • YDR254W
    		•  The BioGRID Database Seperator Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    bait Measday V (2005) [218]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM22
  • YJR135C
    		•  The BioGRID Database Seperator Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    Synthetic Growth Defect
    bait Measday V (2005) [218]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM5
  • PFD5
  • YML094W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRC1
  • YCL060C
  • YCL061C
    		•  The BioGRID Database Seperator S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    hit Dixon SJ (2008) [1412]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP6
  • YLR085C
    		•  The BioGRID Database Seperator Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IML3
  • MCM19
  • YBR107C
    		•  The BioGRID Database Seperator Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    bait Measday V (2005) [218]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLK19
  • YOR195W
    		•  The BioGRID Database Seperator Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    bait Ye P (2005) [294]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM21
  • CTF5
  • YDR318W
    		•  The BioGRID Database Seperator Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    bait Measday V (2005) [218]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAC11
  • YDR488C
    		•  The BioGRID Database Seperator Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKE2
  • GIM1
  • PFD6
  • YLR200W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF4
  • CHL15
  • POB1
  • YPR135W
    		•  The BioGRID Database Seperator Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIP2
  • YPL155C
    		•  The BioGRID Database Seperator Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM16
  • YPR046W
    		•  The BioGRID Database Seperator Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    bait Measday V (2005) [218]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait Dixon SJ (2008) [1412]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC3
  • LEP1
  • YDR159W
    		•  The BioGRID Database Seperator Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWR1
  • YDR334W
    		•  The BioGRID Database Seperator Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Dixon SJ (2008) [1412]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF7
  • YNL136W
    		•  The BioGRID Database Seperator Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM1
  • SPB8
  • YJL124C
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF19
  • MCM18
  • YPL018W
    		•  The BioGRID Database Seperator Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD61
  • YDR014W
    		•  The BioGRID Database Seperator Protein of unknown function; mutation confers radiation sensitivity
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF1
  • VID21
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NIP100
  • PAC13
  • YPL174C
    		•  The BioGRID Database Seperator Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAC10
  • RKS2
  • PFD3
  • GIM2
  • YGR078C
    		•  The BioGRID Database Seperator Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LDB18
  • YLL049W
    		•  The BioGRID Database Seperator Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    bait Amaro IA (2008) [69]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF3
  • CHL3
  • YLR381W
    		•  The BioGRID Database Seperator Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIN1
  • YOR349W
    		•  The BioGRID Database Seperator Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOF1
  • YNL273W
    		•  The BioGRID Database Seperator Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHL1
  • CTF1
  • LPA9
  • YPL008W
    		•  The BioGRID Database Seperator Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Synthetic Growth Defect
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF3
  • YPR023C
    		•  The BioGRID Database Seperator Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait Lin YY (2008) [2599]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUB1
  • YML085C
    		•  The BioGRID Database Seperator Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
    Gene Ontology: [View List]
    Two-hybrid
    hit Schwartz K (1997) [9]
    Synthetic Lethality
    hit Schwartz K (1997) [9]
    Phenotypic Enhancement
    bait Caudron F (2008) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUB3
  • YML124C
    		•  The BioGRID Database Seperator Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p
    Gene Ontology: [View List]
    Two-hybrid
    hit Schwartz K (1997) [9]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLI15
  • YBR156C
    		•  The BioGRID Database Seperator Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p aurora kinase
    Gene Ontology: [View List]
    Two-hybrid
    bait Wong J (2007) [604]
    Reconstituted Complex
    hit Zimniak T (2009) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIM1
  • YEB1
  • YER016W
    		•  The BioGRID Database Seperator Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Wolyniak MJ (2006) [20]
    Two-hybrid
    hit Wolyniak MJ (2006) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS71
  • SWC6
  • YML041C
    		•  The BioGRID Database Seperator Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYK3
  • YDL117W
    		•  The BioGRID Database Seperator SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Dixon SJ (2008) [1412]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YTA7
  • YGR270W
    		•  The BioGRID Database Seperator Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRC15
  • YPL017C
    		•  The BioGRID Database Seperator Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; null mutant displays increased levels of spontaneous Rad52 foci
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NKP1
  • YDR383C
    		•  The BioGRID Database Seperator Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IPK1
  • GSL1
  • YDR315C
    		•  The BioGRID Database Seperator Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS72
  • SWC2
  • YDR485C
    		•  The BioGRID Database Seperator Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM6
  • YDR378C
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE5
  • YNR051C
    		•  The BioGRID Database Seperator Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELG1
  • RTT110
  • YOR144C
    		•  The BioGRID Database Seperator Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Bellaoui M (2003) [57]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLA4
  • ERC10
  • YNL298W
    		•  The BioGRID Database Seperator Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NKP2
  • YLR315W
    		•  The BioGRID Database Seperator Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DYN3
  • YMR299C
    		•  The BioGRID Database Seperator Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIN2
  • YPL241C
    		•  The BioGRID Database Seperator Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PFD1
  • GIM6
  • YJL179W
    		•  The BioGRID Database Seperator Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    bait Ye P (2005) [294]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VIK1
  • YPL253C
    		•  The BioGRID Database Seperator Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIN3
  • CPE1
  • SDI1
  • SDS16
  • YOL004W
    		•  The BioGRID Database Seperator Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Synthetic Lethality
    bait Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRD1
  • YPA1
  • YIL153W
    		•  The BioGRID Database Seperator Activator of the phosphotyrosyl phosphatase activity of PP2A, peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPD3
  • SDI2
  • MOF6
  • REC3
  • YNL330C
    		•  The BioGRID Database Seperator Histone deacetylase; regulates transcription and silencing
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Synthetic Growth Defect
    bait Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAF9
  • YNL107W
    		•  The BioGRID Database Seperator Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Synthetic Growth Defect
    bait Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD50
  • YNL250W
    		•  The BioGRID Database Seperator Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCK1
  • YPK1
  • YNL307C
    		•  The BioGRID Database Seperator Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAP30
  • YMR263W
    		•  The BioGRID Database Seperator Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUB1
  • YGR188C
    		•  The BioGRID Database Seperator Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM4
  • PFD2
  • YEL003W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Pan X (2004) [323]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPZ1
  • YML016C
    		•  The BioGRID Database Seperator Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL22A
  • YLR061W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAM1
  • YGR113W
    		•  The BioGRID Database Seperator Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
    Gene Ontology: [View List]
    Two-hybrid
    bait Shang C (2003) [35]
    Synthetic Lethality
    bait Cheeseman IM (2001) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC34
  • YKR037C
    		•  The BioGRID Database Seperator Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
    Gene Ontology: [View List]
    Two-hybrid
    bait Wong J (2007) [604]
    Synthetic Lethality
    bait Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP133
  • RAT3
  • YKR082W
    		•  The BioGRID Database Seperator Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSM1
  • YCR086W
    		•  The BioGRID Database Seperator Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF5
  • YEL018W
    		•  The BioGRID Database Seperator Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAT1
  • AAA1
  • YDL040C
    		•  The BioGRID Database Seperator Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSY2
  • YNL201C
    		•  The BioGRID Database Seperator Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIA2
  • YOR29-31
  • YOR080W
    		•  The BioGRID Database Seperator Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    bait Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTC6
  • AUP1
  • YCR079W
    		•  The BioGRID Database Seperator Phosphoprotein phosphatase type 2C similar to mammalian PP1Ks; involved in mitophagy; localized to mitochondrial inner membrane space; null mutant is sensitive to rapamycin
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA34
  • YJL148W
    		•  The BioGRID Database Seperator RNA polymerase I subunit A34.5
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRC21
  • YMR073C
    		•  The BioGRID Database Seperator Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52 foci
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KEM1
  • SKI1
  • DST2
  • RAR5
  • YGL173C
    		•  The BioGRID Database Seperator Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA14
  • YDR156W
    		•  The BioGRID Database Seperator RNA polymerase I subunit A14
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPH3
  • YDR075W
    		•  The BioGRID Database Seperator Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP8
  • YOR141C
    		•  The BioGRID Database Seperator Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    bait Hannum G (2009) [496]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARD1
  • YHR013C
    		•  The BioGRID Database Seperator Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPH1
  • YIL103W
    		•  The BioGRID Database Seperator Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POP2
  • CAF1
  • YNR052C
    		•  The BioGRID Database Seperator RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PLP1
  • YDR183W
    		•  The BioGRID Database Seperator Protein with a possible role in folding of beta-tubulin; has weak similarity to phosducins, which are G-protein regulators
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP84
  • YDL116W
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN4
  • UFD5
  • SON1
  • YDL020C
    		•  The BioGRID Database Seperator Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Positive Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUB4
  • YLR212C
    		•  The BioGRID Database Seperator Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Cuschieri L (2006) [9]
    Dosage Rescue
    bait Cuschieri L (2006) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTS1
  • SCS1
  • YOR014W
    		•  The BioGRID Database Seperator B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD51
  • MUT5
  • YER095W
    		•  The BioGRID Database Seperator Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL30
  • YBR088C
    		•  The BioGRID Database Seperator Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005) [564]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STH1
  • NPS1
  • YIL126W
    		•  The BioGRID Database Seperator ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
    Gene Ontology: [View List]
    Dosage Rescue
    bait Hosotani T (2001) [5]
    Synthetic Lethality
    hit Hosotani T (2001) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB5
  • YPR120C
    		•  The BioGRID Database Seperator B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM7
  • YNL147W
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAT1
  • MRT1
  • YCR077C
    		•  The BioGRID Database Seperator Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • SUN1
  • MCB1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
    Gene Ontology: [View List]
    Synthetic Growth Defect