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BioGRID | Network Layout for GCN4 for Saccharomyces cerevisiae
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GCN4

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: ARG9, AAS3, YEL009C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 10 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with GCN4

GCN4 was identified with 79 protein interactions and 37 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 ADA2
  • SWI8
  • YDR448W
    		•  The BioGRID Database Seperator Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Natarajan K (1998) [28]
    hit Drysdale CM (1998) [23]
    Reconstituted Complex
    bait Barlev NA (1995) [2]
    hit Utley RT (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF2
  • SWI2
  • GAM1
  • TYE3
  • YOR290C
    		•  The BioGRID Database Seperator Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Neely KE (2002) [14]
    hit Neely KE (1999) [7]
    Co-localization
    bait Kim Y (2006) [1]
    Two-hybrid
    hit Lim MK (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF5
  • HAF4
  • SWI10
  • TYE4
  • YBR289W
    		•  The BioGRID Database Seperator Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Prochasson P (2003) [2]
    hit Neely KE (2002) [14]
    hit Natarajan K (1999) [5]
    hit Yoon S (2004) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO85
  • LDB15
  • YPL031C
    		•  The BioGRID Database Seperator Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5
    Gene Ontology: [View List]
    Biochemical Activity
    bait Shemer R (2002) [1]
    bait Meimoun A (2000) [4]
    bait Aviram S (2008) [3]
    Dosage Lethality
    bait Sopko R (2006) [65]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB2
  • HRS2
  • MED20
  • YHR041C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Natarajan K (1999) [5]
    hit Natarajan K (1998) [28]
    hit Drysdale CM (1998) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF5
  • TAF90
  • YBR198C
    		•  The BioGRID Database Seperator Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Natarajan K (1999) [5]
    hit Natarajan K (1998) [28]
    hit Drysdale CM (1998) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • SUN1
  • MCB1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Seong KM (2007) [75]
    bait Seong KM (2007) [3]
    Affinity Capture-Western
    bait Seong KM (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF9
  • TAF17
  • YMR236W
    		•  The BioGRID Database Seperator Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Natarajan K (1999) [5]
    hit Natarajan K (1998) [28]
    hit Drysdale CM (1998) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB7
  • MED21
  • YDR308C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Swanson MJ (2003) [3]
    hit Park JM (2000) [15]
    hit Natarajan K (1998) [28]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MBF1
  • SUF13
  • YOR298C-A
    		•  The BioGRID Database Seperator Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Takemaru K (1998) [5]
    Reconstituted Complex
    hit Takemaru K (1998) [5]
    Dosage Rescue
    hit Takemaru K (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL11
  • SPT13
  • ABE1
  • MED15
  • YOL051W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Park JM (2000) [15]
    Two-hybrid
    bait/hit Lim MK (2007) [75]
    Dosage Rescue
    hit Lim MK (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN2
  • AAS1
  • YDR283C
    		•  The BioGRID Database Seperator Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex
    Gene Ontology: [View List]
    Two-hybrid
    bait Millson SH (2004) [35]
    Synthetic Rescue
    bait Hinnebusch AG (1984) [1]
    Dosage Rescue
    bait Hinnebusch AG (1983) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT7
  • GIT2
  • YBR081C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Natarajan K (1998) [28]
    Reconstituted Complex
    hit Utley RT (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF6
  • TAF60
  • YGL112C
    		•  The BioGRID Database Seperator Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Natarajan K (1998) [28]
    hit Drysdale CM (1998) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN4
  • ARG9
  • AAS3
  • YEL009C
    		•  The BioGRID Database Seperator Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Hope IA (1987) [1]
    Protein-peptide
    hit Gullà SV (2009) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT3
  • YDR392W
    		•  The BioGRID Database Seperator Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Utley RT (1998) [5]
    Two-hybrid
    hit Lim MK (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF12
  • SWP73
  • YNR023W
    		•  The BioGRID Database Seperator 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Swanson MJ (2003) [3]
    hit Natarajan K (1999) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI1
  • GAM3
  • LPA1
  • ADR6
  • YPL016W
    		•  The BioGRID Database Seperator Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Prochasson P (2003) [2]
    hit Neely KE (2002) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB4
  • MED17
  • YER022W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Park JM (2000) [15]
    hit Drysdale CM (1998) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PGD1
  • MED3
  • HRS1
  • YGL025C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Park JM (2000) [15]
    Far Western
    hit Park JM (2000) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC4
  • YFL009W
    		•  The BioGRID Database Seperator F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
    Gene Ontology: [View List]
    Two-hybrid
    bait Kishi T (2008) [5]
    Dosage Lethality
    bait Meimoun A (2000) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLN3
  • YER040W
    		•  The BioGRID Database Seperator Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source
    Gene Ontology: [View List]
    Synthetic Rescue
    bait/hit Valenzuela L (2001) [2]
    Phenotypic Enhancement
    bait Mitchell AP (1984) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOR1
  • DRR1
  • YJR066W
    		•  The BioGRID Database Seperator PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    Synthetic Rescue
    hit Wang C (2009) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM6
  • YGL201C
    		•  The BioGRID Database Seperator Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
    Gene Ontology: [View List]
    Two-hybrid
    bait Millson SH (2004) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT5
  • YTA1
  • YOR117W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Seong KM (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPC10
  • RPB12
  • YHR143W-A
    		•  The BioGRID Database Seperator RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET31
  • YPL038W
    		•  The BioGRID Database Seperator Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32p
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Seong KM (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AHC1
  • YOR023C
    		•  The BioGRID Database Seperator Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF13
  • TAF19
  • FUN81
  • YML098W
    		•  The BioGRID Database Seperator TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCL1
  • YPR025C
    		•  The BioGRID Database Seperator Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUA7
  • SOH4
  • YPR086W
    		•  The BioGRID Database Seperator Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007) [75]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM16
  • YPR046W
    		•  The BioGRID Database Seperator Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA
    Gene Ontology: [View List]
    Two-hybrid
    bait Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP7
  • SWP61
  • RSC11
  • YPR034W
    		•  The BioGRID Database Seperator Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Neely KE (1999) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT20
  • ADA5
  • YOL148C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Natarajan K (1998) [28]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MED4
  • YOR174W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Park JM (2000) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN6
  • NAS4
  • YDL097C
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD6
  • UBC2
  • PSO8
  • YGL058W
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
    Gene Ontology: [View List]
    Biochemical Activity
    bait Kornitzer D (1994) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STH1
  • NPS1
  • YIL126W
    		•  The BioGRID Database Seperator ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Swanson MJ (2003) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF12
  • TAF61
  • TAF68
  • YDR145W
    		•  The BioGRID Database Seperator Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Natarajan K (1998) [28]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF14
  • SWP29
  • TFG3
  • ANC1
  • YPL129W
    		•  The BioGRID Database Seperator Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Neely KE (1999) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF1
  • TAF130
  • TAF145
  • YGR274C
    		•  The BioGRID Database Seperator TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Drysdale CM (1998) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT15
  • TBP1
  • BTF1
  • YER148W
    		•  The BioGRID Database Seperator TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Melcher K (1995) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNG2
  • EAF4
  • NBN1
  • YHR090C
    		•  The BioGRID Database Seperator Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Utley RT (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EPL1
  • YFL024C
    		•  The BioGRID Database Seperator Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Utley RT (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSN3
  • NUT7
  • GIG2
  • CDK8
  • YPL042C
    		•  The BioGRID Database Seperator Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
    Gene Ontology: [View List]
    Biochemical Activity
    bait Chi Y (2001) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NGG1
  • ADA3
  • SWI7
  • YDR176W
    		•  The BioGRID Database Seperator Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Drysdale CM (1998) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO21
  • SUA8
  • RPB220
  • RPB1
  • YDL140C
    		•  The BioGRID Database Seperator RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Brandl CJ (1989) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCL5
  • YHR071W
    		•  The BioGRID Database Seperator Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Aviram S (2008) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL6B
  • YLR448W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BAS1
  • YKR099W
    		•  The BioGRID Database Seperator Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Joo YJ (2009) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL21A
  • URP1
  • YBR191W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL34B
  • YIL052C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPP2B
  • RPL45
  • YPA1
  • YDR382W
    		•  The BioGRID Database Seperator Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHC3
  • BTN1
  • YJL059W
    		•  The BioGRID Database Seperator Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Vitiello SP (2007) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Wang C (2009) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL43B
  • YJR094W-A
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD27
  • URI1
  • YFL023W
    		•  The BioGRID Database Seperator Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by the TOR kinase; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Deplazes A (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKE2
  • GIM1
  • PFD6
  • YLR200W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Deplazes A (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IWR1
  • YDL115C
    		•  The BioGRID Database Seperator Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Peiro-Chova L (2009) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC28
  • CDK1
  • SRM5
  • HSL5
  • YBR160W
    		•  The BioGRID Database Seperator Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Tobe BT (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN3
  • AAS2
  • YKR026C
    		•  The BioGRID Database Seperator Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
    Gene Ontology: [View List]
    Dosage Rescue
    bait Hinnebusch AG (1983) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AFR1
  • YDR085C
    		•  The BioGRID Database Seperator Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Tavernarakis N (1995) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URE2
  • YNL229C
    		•  The BioGRID Database Seperator Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Sosa E (2003) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATR1
  • SNQ1
  • YML116W
    		•  The BioGRID Database Seperator Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide
    Gene Ontology: [View List]
    Dosage Rescue
    hit Kanazawa S (1988) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC53
  • YDL132W
    		•  The BioGRID Database Seperator Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
    Gene Ontology: [View List]
    Dosage Lethality
    bait Meimoun A (2000) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC34
  • UBC3
  • DNA6
  • YDR054C
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation
    Gene Ontology: [View List]
    Dosage Lethality
    bait Meimoun A (2000) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCD1
  • TRA3
  • YOR260W
    		•  The BioGRID Database Seperator Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Hinnebusch AG (1983) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKO1
  • ACR1
  • YNL167C
    		•  The BioGRID Database Seperator Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Pascual-Ahuir A (2001) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL21B
  • YPL079W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL23A
  • YBL087C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL17A
  • RPL17
  • YKL180W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL20B
  • RPL18A1
  • YOR312C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL31A
  • RPL34
  • YDL075W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL29
  • YFR032C-A
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Steffen KK (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.