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BioGRID | Network Layout for RAD23 for Saccharomyces cerevisiae
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RAD23

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YEL037C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins|Rad23p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 9 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RAD23

RAD23 was identified with 119 protein interactions and 70 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 RAD4
  • YER162C
    		•  The BioGRID Database Seperator Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein|Rad4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    hit Collins SR (2007)
    Two-hybrid
    bait Uetz P (2000)
    bait/hit Wang Z (1997)
    bait Wei S (1998)
    bait den Dulk B (2008)
    Affinity Capture-Western
    bait/hit Suzuki T (2001)
    bait/hit Jansen LE (1998)
    hit Schauber C (1998)
    bait Ortolan TG (2004)
    Co-purification
    hit Schauber C (1998)
    Phenotypic Suppression
    hit Xie Z (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD2
  • YDL190C
    		•  The BioGRID Database Seperator Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3|Ufd2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    hit Krogan NJ (2006)
    Two-hybrid
    bait Kim I (2004)
    bait Richly H (2005)
    Affinity Capture-Western
    hit Kim I (2004)
    hit Richly H (2005)
    Reconstituted Complex
    bait Kim I (2004)
    Co-purification
    bait Rumpf S (2006)
    Synthetic Rescue
    hit Ortolan TG (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PNG1
  • YPL096W
    		•  The BioGRID Database Seperator Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation, localizes to the cytoplasm and nucleus, interacts with the DNA repair protein Rad23p|Png1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Suzuki T (2001)
    hit Kim I (2006)
    Two-hybrid
    hit Suzuki T (2001)
    hit Kim I (2006)
    Reconstituted Complex
    hit Biswas S (2004)
    Co-crystal Structure
    bait Lee JH (2005)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • MCB1
  • SUN1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein|Rpn10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    Affinity Capture-Western
    hit Ghaboosi N (2007)
    Phenotypic Enhancement
    bait Chen L (2002)
    bait Saeki Y (2002)
    bait Elsasser S (2004)
    bait Collins SR (2007)
    Synthetic Lethality
    hit Lambertson D (1999)
    Synthetic Growth Defect
    hit Chuang SM (2005)
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT6
  • CIM3
  • CRL3
  • SCB68
  • YGL048C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle|Rpt6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    Affinity Capture-Western
    hit Schauber C (1998)
    hit Sun L (2002)
    hit Lambertson D (2003)
    hit Russell SJ (1999)
    Co-purification
    hit Ferdous A (2001)
    Phenotypic Enhancement
    bait Gillette TG (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DDI1
  • VSM1
  • YER143W
    		•  The BioGRID Database Seperator DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control|Ddi1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Rao H (2002)
    hit Bertolaet BL (2001)
    Affinity Capture-Western
    hit Bertolaet BL (2001)
    Co-fractionation
    hit Bertolaet BL (2001)
    Reconstituted Complex
    bait/hit Kang Y (2006)
    Phenotypic Enhancement
    hit Diaz-Martinez LA (2006)
    bait Auesukaree C (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT1
  • CIM5
  • YTA3
  • YKL145W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p|Rpt1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Schauber C (1998)
    hit Lambertson D (2003)
    hit Sun L (2002)
    hit Ishii T (2006)
    Co-purification
    hit Schauber C (1998)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN1
  • HRD2
  • NAS1
  • YHR027C
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions|Rpn1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Elsasser S (2002)
    bait Ishii T (2006)
    Two-hybrid
    bait Cagney G (2001)
    hit Kim I (2004)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    Affinity Capture-Western
    hit Ishii T (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DSK2
  • YMR276W
    		•  The BioGRID Database Seperator Dsk2p|Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Rao H (2002)
    Phenotypic Enhancement
    hit Saeki Y (2002)
    hit Medicherla B (2004)
    hit Diaz-Martinez LA (2006)
    Synthetic Growth Defect
    bait Biggins S (1996)
    hit Kim I (2004)
    hit Richly H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubi4p|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Bertolaet BL (2001)
    Two-hybrid
    hit Bertolaet BL (2001)
    Reconstituted Complex
    bait Hobeika M (2007)
    Co-crystal Structure
    hit Haririnia A (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT4
  • CRL13
  • PCS1
  • SUG2
  • YOR259C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle|Rpt4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Russell SJ (1999)
    Co-purification
    hit Ferdous A (2001)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    Phenotypic Enhancement
    bait Gillette TG (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT5
  • YTA1
  • YOR117W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription|Rpt5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Saeki Y (2002)
    Co-purification
    hit Ferdous A (2001)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN9
  • YDR427W
    		•  The BioGRID Database Seperator Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects|Rpn9p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    Affinity Capture-Western
    hit Saeki Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT3
  • YNT1
  • YTA2
  • YDR394W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B|Rpt3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    Affinity Capture-Western
    hit Ishii T (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YML011C
  • RAD33
    		•  The BioGRID Database Seperator Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus|Rad33p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    Phenotypic Enhancement
    hit den Dulk B (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD14
  • YMR201C
    		•  The BioGRID Database Seperator Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein|Rad14p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Guzder SN (1995)
    Affinity Capture-Western
    bait Rodriguez K (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT2
  • YHS4
  • YTA5
  • YDL007W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle|Rpt2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD23
  • YEL037C
    		•  The BioGRID Database Seperator Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins|Rad23p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Rao H (2002)
    Reconstituted Complex
    bait/hit Kang Y (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD6
  • UBC2
  • YGL058W
    		•  The BioGRID Database Seperator Rad6p|Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p); protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schiestl RH (1989)
    bait Ramsey KL (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC4
  • YBR082C
    		•  The BioGRID Database Seperator Ubc4p|Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Ortolan TG (2000)
    Phenotypic Suppression
    hit Ortolan TG (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD51
  • MUT5
  • YER095W
    		•  The BioGRID Database Seperator Rad51p|Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTH2
  • YBL057C
    		•  The BioGRID Database Seperator One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth|Pth2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Ishii T (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN11
  • MPR1
  • YFR004W
    		•  The BioGRID Database Seperator Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates|Rpn11p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS167
  • YDR388W
    		•  The BioGRID Database Seperator Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin|Rvs167p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEM1
  • DSS1
  • HOD1
  • YDR363W-A
    		•  The BioGRID Database Seperator Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1|Sem1p; protein coding