| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
|
| SMI1 |
KNR4YGR229C |
|
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
|
|
|
|
|
| FKS1 |
CWH53GSC1PBR1YLR342W |
|
Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
|
|
|
|
|
| BNI1 |
SHE5PPF3YNL271C |
|
Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
|
|
|
|
|
| MNN10 |
BED1SLC2REC41YDR245W |
|
Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
|
|
|
|
|
| CCW12 |
YLR110C |
|
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
|
|
|
|
|
| OPI3 |
PEM2YJR073C |
|
Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
|
|
|
|
|
| BCK1 |
LAS3SSP31SAP3YJL095W |
|
Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
|
|
|
|
|
| SLT2 |
BYC2MPK1SLK2YHR030C |
|
Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
|
|
|
|
|
| RVS167 |
YDR388W |
|
Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin
|
|
|
|
|
| CYK3 |
YDL117W |
|
SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis
|
|
|
|
|
| GAS1 |
GGP1CWH52YMR307W |
|
Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
|
|
|
|
|
| SLA1 |
YBL007C |
|
Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
|
|
|
|
|
| CLA4 |
ERC10YNL298W |
|
Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
|
|
|
|
|
| SHE4 |
DIM1YOR035C |
|
Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
|
|
|
|
|
| TPM1 |
YNL079C |
|
Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
|
|
|
|
|
| MYO2 |
CDC66YOR326W |
|
One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
|
|
|
|
|
| SAC6 |
ABP67YDR129C |
|
Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
|
|
|
|
|
| EDE1 |
BUD15YBL047C |
|
Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
|
|
|
|
|
| PRE9 |
YGR135W |
|
20S proteasome beta-type subunit; the only nonessential 20S subunit
|
|
|
|
|
| RPO41 |
YFL036W |
|
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
|
|
|
|
|
| RPA34 |
YJL148W |
|
RNA polymerase I subunit A34.5
|
|
|
|
|
| RVS161 |
FUS7END6SPE161YCR009C |
|
Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
|
|
|
|
|
| YNL181W |
YNL181W |
|
Putative oxidoreductase; required for cell viability
|
|
|
|
|
| LAS21 |
GPI7YJL062W |
|
Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity
|
|
|
|
|
| ERG2 |
END11YMR202W |
|
C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
|
|
|
|
|
| VAN1 |
LDB13VRG8VRG7YML115C |
|
Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
|
|
|
|
|
| TUS1 |
SOP10YLR425W |
|
Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
|
|
|
|
|
| SMY1 |
YKL079W |
|
Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
|
|
|
|
|
| NUP133 |
RAT3YKR082W |
|
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
|
|
|
|
|
| VRP1 |
YLR337WMDP2END5YLR337C |
|
Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
|
|
|
|
|
| QDR2 |
YIL121W |
|
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake
|
|
|
|
|
| PEX6 |
PAS8YNL329C |
|
AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol
|
|
|
|
|
| ARC40 |
YBR234C |
|
Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
|
|
|
|
|
| ARP2 |
ACT2YDL029W |
|
Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
|
|
|
|
|
| SHR3 |
APF1YDL212W |
|
Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
|
|
|
|
|
| FEN1 |
GNS1ELO2VBM2YCR034W |
|
Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
|
|
|
|
|
| ERV29 |
YGR284C |
|
Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo
|
|
|
|
|
| LAG1 |
YHL003C |
|
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
|
|
|
|
|
| CAN1 |
YEL063C |
|
Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance
|
|
|
|
|
| SNL1 |
YIL016W |
|
Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
|
|
|
|
|
| IFA38 |
YBR159W |
|
Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
|
|
|
|
|
| COS8 |
YHL048W |
|
Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response
|
|
|
|
|
| TNA1 |
YGR260W |
|
High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
|
|
|
|
|
| PHO88 |
YBR106W |
|
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
|
|
|
|
|
| ALG1 |
YBR110W |
|
Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
|
|
|
|
|
| PHO86 |
YJL117W |
|
Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles
|
|
|
|
|
| PBN1 |
YCL052C |
|
Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
|
|
|
|
|
| SUR2 |
SYR2YDR297W |
|
Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
|
|
|
|
|
| HEK2 |
KHD1YBL032W |
|
RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
|
|
|
|
|
| SWE1 |
WEE1YJL187C |
|
Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
|
|
|
|
|
| ELO1 |
YJL196C |
|
Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
|
|
|
|
|
| KEX1 |
YGL203C |
|
Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
|
|
|
|
|
| CHS3 |
CSD2KTI2DIT101YBR023C |
|
Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
|
|
|
|
|
| PHO91 |
YNR013C |
|
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
|
|
|
|
|
| COT1 |
YOR316C |
|
Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium
|
|
|
|
|
| SRP102 |
YKL154W |
|
Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane
|
|
|
|
|
| STE24 |
AFC1PIO2YJR117W |
|
Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
|
|
|
|
|
| YJR015W |
YJR015W |
|
Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene
|
|
|
|
|
| NAB2 |
YGL122C |
|
Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
|
|
|
|
|
| SUR4 |
SRE1APA1VBM1YLR372W |
|
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
|
|
|
|
|
| GSF2 |
ECM6YML048W |
|
ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
|
|
|
|
|
| PRR1 |
YKL116C |
|
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
|
|
|
|
|
| YKR005C |
YKR005C |
|
Putative protein of unknown function
|
|
|
|
|
| LOT5 |
YKL183W |
|
Protein of unknown function; gene expression increases in cultures shifted to a lower temperature
|
|
|
|
|
| SPA2 |
PEA1FUS6YLL021W |
|
Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
|
|
|
|
|
| MNL1 |
HTM1YHR204W |
|
Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides
|
|
|
|
|
| BUD14 |
YAR014C |
|
Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
|
|
|
|
|
| PSK2 |
YOL045W |
|
One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)
|
|
|
|
|
| MNN11 |
YJL183W |
|
Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
|
|
|
|
|
| HSP150 |
PIR2CCW7ORE1YJL159W |
|
O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation
|
|
|
|
|
| PTK2 |
STK2YJR059W |
|
Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
|
|
|
|
|
| HOC1 |
YJR075W |
|
Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
|
|
|
|
|
| SWP1 |
YMR149W |
|
Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
|
|
|
|
|
| CDC3 |
YLR314C |
|
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
|
|
|
|
|
| ARV1 |
YLR242C |
|
Protein required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein
|
|
|
|
|
| ARC18 |
YLR370C |
|
Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
|
|
|
|
|
| GAB1 |
CDC91YLR459W |
|
GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
|
|
|
|
|
| TEL2 |
YGR099W |
|
Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect
|
|
|
|
|
| ILM1 |
YJR118C |
|
Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
|
|
|
|
|
| CDC11 |
PSL9YJR076C |
|
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
|
|
|
|
|
| VPS5 |
PEP10GRD2VPT5YOR069W |
|
Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p
|
|
|
|
|
| VPS21 |
YPT21YPT51VPS12YOR089C |
|
GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog
|
|
|
|
|
| ARC15 |
YIL062C |
|
Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
|
|
|
|
|
| GWT1 |
YJL091C |
|
Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
|
|
|
|
|
| RPP2A |
RPL44RPLA2YOL039W |
|
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
|
|
|
|
|
| GDA1 |
YEL042W |
|
Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
|
|
|
|
|
| SEC66 |
HSS1SEC71YBR171W |
|
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
|
|
|
|
|
| PER1 |
COS16YCR044C |
|
Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
|
|
|
|
|
| WBP1 |
YEL002C |
|
Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum
|
|
|
|
|
| VRG4 |
VAN2LDB3VIG4YGL225W |
|
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
|
|
|
|
|
| RUD3 |
GRP1YOR216C |
|
Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
|
|
|
|
|
| GUP1 |
YGL084C |
|
Plasma membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases
|
|
|
|
|
| TSC3 |
YBR058C-A |
|
Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
|
|
|
|
|
| CHS6 |
CSD3YJL099W |
|
Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
|
|
|
|
|
| ARF1 |
YDL192W |
|
ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
|
|
|
|
|
| BFR1 |
YOR198C |
|
Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
|
|
|
|
|
| BST1 |
PER17YFL025C |
|
GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
|
|
|
|
|
| FMO1 |
YHR176W |
|
Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
|
|
|
|
|
| SVP26 |
ERV26YHR181W |
|
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
|
|
|
|
|
| ANP1 |
MNN8GEM3YEL036C |
|
Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
|
|
|
|
|
| TSC11 |
AVO3YER093C |
|
Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain
|
|
|
|
|
| BEM2 |
IPL2SUP9TSL1YER155C |
|
Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
|
|
|
|
|
| ACT1 |
ABY1END7YFL039C |
|
Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
|
|
|
|
|
| GPI8 |
YDR331W |
|
ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
|
|
|
|
|
| SSD1 |
CLA1MCS1SRK1YDR293C |
|
Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence
|
|
|
|
|
| SPF1 |
COD1PER9PIO1YEL031W |
|
P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
|
|
|
|
|
| VPS8 |
VPT8FUN15YAL002W |
|
Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif
|
|
|
|
|
| CMD1 |
YBR109C |
|
Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
|
|
|
|
|
| CDC10 |
YCR002C |
|
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
|
|
|
|
|
| SEC9 |
HSS7YGR009C |
|
t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
|
|
|
|
|
