The BioGRID Database Seperator
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BioGRID | Network Layout for CLB2 for Saccharomyces cerevisiae
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CLB2

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YPR119W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 16 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with CLB2

CLB2 was identified with 274 protein interactions and 204 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 CDC28
  • CDK1
  • SRM5
  • HSL5
  • YBR160W
    		•  The BioGRID Database Seperator Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Honey S (2001) [21]
    hit Archambault V (2004) [74]
    hit Krogan NJ (2006) [7079]
    bait Kito K (2008) [15]
    Affinity Capture-Western
    hit Shellman YG (1999) [2]
    hit Bailly E (2003) [2]
    hit Schwab M (2001) [10]
    hit Ross KE (2000) [2]
    hit Kaiser P (1999) [16]
    hit Lim HH (1996) [2]
    hit Hu F (2008) [5]
    Biochemical Activity
    bait Hu F (2008) [5]
    Dosage Rescue
    bait Ahn SH (2001) [6]
    bait Surana U (1991) [7]
    bait Tobe BT (2009) [11]
    Synthetic Lethality
    bait/hit Surana U (1991) [7]
    hit Ahn SH (2001) [6]
    bait Tobe BT (2009) [11]
    Phenotypic Enhancement
    bait Tobe BT (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIC1
  • SDB25
  • YLR079W
    		•  The BioGRID Database Seperator Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Honey S (2001) [21]
    hit Archambault V (2004) [74]
    Affinity Capture-Western
    hit Bailly E (1999) [2]
    bait Archambault V (2004) [74]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Dosage Lethality
    bait Kramer KM (1998) [6]
    bait Toyn JH (1997) [4]
    Dosage Rescue
    hit Archambault V (2003) [19]
    hit Waesch R (2002) [2]
    Synthetic Lethality
    hit Cross FR (2007) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDH1
  • HCT1
  • YGL003C
    		•  The BioGRID Database Seperator Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    Affinity Capture-Western
    bait/hit Schwab M (2001) [10]
    bait Burton JL (2001) [6]
    bait Burton JL (2005) [4]
    bait Ostapenko D (2008) [5]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    hit Zachariae W (1998) [4]
    Dosage Lethality
    bait Cross FR (2005) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC6
  • YJL194W
    		•  The BioGRID Database Seperator Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Archambault V (2003) [19]
    bait Archambault V (2004) [74]
    hit Drury LS (2009) [2]
    Affinity Capture-MS
    hit Archambault V (2004) [74]
    Reconstituted Complex
    bait Mimura S (2004) [1]
    Dosage Rescue
    hit Archambault V (2003) [19]
    Dosage Lethality
    bait Cross FR (2005) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKS1
  • YBR135W
    		•  The BioGRID Database Seperator Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    hit Honey S (2001) [21]
    hit Archambault V (2004) [74]
    Two-hybrid
    hit Uetz P (2000) [875]
    Affinity Capture-Western
    hit Kaiser P (1999) [16]
    bait Rudner AD (2000) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC23
  • YHR166C
    		•  The BioGRID Database Seperator Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Meyn MA (2002) [2]
    Two-hybrid
    hit Meyn MA (2002) [2]
    Synthetic Lethality
    hit Rudner AD (2000) [12]
    bait Irniger S (2000) [14]
    Phenotypic Enhancement
    bait Irniger S (1995) [2]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD3
  • YCL012W
  • YCL014W
    		•  The BioGRID Database Seperator Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
    Gene Ontology: [View List]
    Two-hybrid
    bait Bailly E (2003) [2]
    Affinity Capture-MS
    hit Archambault V (2004) [74]
    Affinity Capture-Western
    bait Archambault V (2004) [74]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWE1
  • WEE1
  • YJL187C
    		•  The BioGRID Database Seperator Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    Two-hybrid
    bait McMillan JN (2002) [6]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Affinity Capture-Western
    bait Hu F (2008) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB1
  • SCB1
  • YGR108W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Honey S (2001) [21]
    Synthetic Lethality
    bait Cross FR (1999) [1]
    bait Surana U (1991) [7]
    bait Richardson H (1992) [2]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBF2
  • YGR092W
    		•  The BioGRID Database Seperator Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Archambault V (2004) [74]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Dosage Lethality
    bait Jaspersen SL (1998) [31]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC20
  • PAC5
  • YGL116W
    		•  The BioGRID Database Seperator Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Searle JS (2004) [8]
    bait Burton JL (2001) [6]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF8
  • YHR191C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    bait Pan X (2006) [5331]
    Synthetic Growth Defect
    bait Mayer ML (2004) [26]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Fiedler D (2009) [4053]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI4
  • ART1
  • YER111C
    		•  The BioGRID Database Seperator DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Amon A (1993) [2]
    Affinity Capture-Western
    hit Siegmund RF (1996) [4]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAP1
  • YKR048C
    		•  The BioGRID Database Seperator Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Miyaji-Yamaguchi M (2003) [2]
    bait Kellogg DR (1995) [1]
    Affinity Capture-MS
    hit Archambault V (2004) [74]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCC1
  • YCL016C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Fiedler D (2009) [4053]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC15
  • LYT1
  • YAR019C
    		•  The BioGRID Database Seperator Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
    Gene Ontology: [View List]
    Dosage Lethality
    bait Jaspersen SL (1998) [31]
    bait Krebs JE (2000) [3]
    Dosage Rescue
    bait Jimenez J (1998) [1]
    bait Goranov AI (2009) [4]
    Synthetic Growth Defect
    bait Eluere R (2007) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASE1
  • YOR29-09
  • YOR058C
    		•  The BioGRID Database Seperator Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LTE1
  • MSI2
  • YAL024C
    		•  The BioGRID Database Seperator Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Archambault V (2004) [74]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Synthetic Growth Defect
    bait Ye P (2005) [294]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD50
  • YNL250W
    		•  The BioGRID Database Seperator Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     XRS2
  • YDR369C
    		•  The BioGRID Database Seperator Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Grandin N (2003) [4]
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB3
  • YDL155W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Richardson H (1992) [2]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Fiedler D (2009) [4053]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIN8
  • SDS15
  • KSL2
  • YEL061C
    		•  The BioGRID Database Seperator Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    bait Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF18
  • CHL12
  • YMR078C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELM1
  • LDB9
  • YKL048C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC5
  • PKX2
  • MSD2
  • YMR001C
    		•  The BioGRID Database Seperator Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Dosage Lethality
    bait Wang Y (2003) [20]
    bait Charles JF (1998) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI5
  • YDR146C
    		•  The BioGRID Database Seperator Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Dosage Lethality
    bait Toyn JH (1997) [4]
    bait Krebs JE (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FKH2
  • YNL068C
    		•  The BioGRID Database Seperator Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Dosage Rescue
    bait Hollenhorst PC (2000) [4]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRS4
  • YDR439W
    		•  The BioGRID Database Seperator Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRP1
  • KAP60
  • SCM1
  • YNL189W
    		•  The BioGRID Database Seperator Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Archambault V (2004) [74]
    Reconstituted Complex
    hit Hahn S (2008) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACE2
  • YLR131C
    		•  The BioGRID Database Seperator Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Archambault V (2004) [74]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM3
  • YEL032W
    		•  The BioGRID Database Seperator Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    hit Liku ME (2005) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KEL1
  • YHR158C
    		•  The BioGRID Database Seperator Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Archambault V (2004) [74]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NET1
  • ESC5
  • CFI1
  • SRM8
  • YJL076W
    		•  The BioGRID Database Seperator Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    hit Azzam R (2004) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT101
  • CUL8
  • YJL047C
    		•  The BioGRID Database Seperator Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Fiedler D (2009) [4053]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT109
  • KIM2
  • REM50
  • YLL002W
    		•  The BioGRID Database Seperator Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Fillingham J (2008) [158]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSM1
  • YCR086W
    		•  The BioGRID Database Seperator Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSL1
  • NIK1
  • YKL101W
    		•  The BioGRID Database Seperator Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Fiedler D (2009) [4053]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC14
  • OAF3
  • YFR028C
    		•  The BioGRID Database Seperator Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit
    Gene Ontology: [View List]
    Dosage Lethality
    bait Jaspersen SL (1998) [31]
    Synthetic Lethality
    hit Yuste-Rojas M (2000) [8]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     XBP1
  • YIL101C
    		•  The BioGRID Database Seperator Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Synthetic Rescue
    bait Miled C (2001) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP3
  • YER151C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Honey S (2001) [21]
    Positive Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLK19
  • YOR195W
    		•  The BioGRID Database Seperator Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI3
  • YNL197C
    		•  The BioGRID Database Seperator RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start
    Gene Ontology: [View List]
    Protein-RNA
    bait Colomina N (2008) [318]
    Phenotypic Suppression
    bait Colomina N (2009) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPA2
  • PEA1
  • FUS6
  • YLL021W
    		•  The BioGRID Database Seperator Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Synthetic Rescue
    bait/hit Sheu YJ (2000) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDS1
  • YDR113C
    		•  The BioGRID Database Seperator Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Synthetic Growth Defect
    bait Sarin S (2004) [37]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIN4
  • ERC47
  • YDR507C
    		•  The BioGRID Database Seperator Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Positive Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI6
  • PSL8
  • SDS11
  • YLR182W
    		•  The BioGRID Database Seperator Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHL1
  • CTF1
  • LPA9
  • YPL008W
    		•  The BioGRID Database Seperator Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASF1
  • CIA1
  • YJL115W
    		•  The BioGRID Database Seperator Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL32
  • YJR043C
    		•  The BioGRID Database Seperator Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIK1
  • YMR198W
    		•  The BioGRID Database Seperator Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p
    Gene Ontology: [View List]
    Positive Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLA4
  • ERC10
  • YNL298W
    		•  The BioGRID Database Seperator Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • SUN1
  • MCB1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FKH1
  • YIL131C
    		•  The BioGRID Database Seperator Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching
    Gene Ontology: [View List]
    Dosage Rescue
    bait Hollenhorst PC (2000) [4]
    Phenotypic Suppression
    bait Casey L (2008) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC22
  • TSL26
  • SLY2
  • YLR268W
    		•  The BioGRID Database Seperator R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF4
  • CHL15
  • POB1
  • YPR135W
    		•  The BioGRID Database Seperator Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWM1
  • YDR260C
    		•  The BioGRID Database Seperator Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS22
  • SLM2
  • YLR320W
    		•  The BioGRID Database Seperator Protein involved in resistance to ionizing radiation; acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Dhillon N (2006) [8]
    Positive Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD52
  • YML032C
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Grandin N (2003) [4]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAK1
  • CIV1
  • YFL029C
    		•  The BioGRID Database Seperator Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
    Gene Ontology: [View List]
    Dosage Rescue
    bait Kaldis P (1996) [3]
    Synthetic Lethality
    bait Kaldis P (1996) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRE11
  • XRS4
  • NGS1
  • RAD58
  • YMR224C
    		•  The BioGRID Database Seperator Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIP2
  • YPL155C
    		•  The BioGRID Database Seperator Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSK1
  • YLR006C
    		•  The BioGRID Database Seperator Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BSP1
  • YPR171W
    		•  The BioGRID Database Seperator Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YOX1
  • YML027W
    		•  The BioGRID Database Seperator Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAC1
  • YOR178C
    		•  The BioGRID Database Seperator Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IPL1
  • PAC15
  • YPL209C
    		•  The BioGRID Database Seperator Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASH1
  • YKL185W
    		•  The BioGRID Database Seperator Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKR078W
  • YKR078W
    		•  The BioGRID Database Seperator Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAR1
  • YJL157C
    		•  The BioGRID Database Seperator Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YEN1
  • YER041W
    		•  The BioGRID Database Seperator Protein of unknown function, has similarity to endonuclease Rth1p; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM1
  • SRO1
  • YBR200W
    		•  The BioGRID Database Seperator Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFG1
  • RAP74
  • SSU71
  • YGR186W
    		•  The BioGRID Database Seperator TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PKH2
  • YOL100W
    		•  The BioGRID Database Seperator Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDL089W
  • YDL089W
    		•  The BioGRID Database Seperator Protein of unknown function; interacts with meiotic division protein Csm1p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery, potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FMT1
  • YBL013W
    		•  The BioGRID Database Seperator Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCL7
  • YIL050W
    		•  The BioGRID Database Seperator Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRS2
  • HPR5
  • YJL092W
    		•  The BioGRID Database Seperator DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TGL4
  • STC1
  • YKR089C
    		•  The BioGRID Database Seperator Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPC54
  • YOR177C
    		•  The BioGRID Database Seperator Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAR10
  • YLR238W
    		•  The BioGRID Database Seperator Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BBP1
  • YPL255W
    		•  The BioGRID Database Seperator Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IFH1
  • YLR223C
    		•  The BioGRID Database Seperator Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZIP1
  • YDR285W
    		•  The BioGRID Database Seperator Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NBA1
  • YOL070C
    		•  The BioGRID Database Seperator Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, and bud neck; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYC2
  • YOR037W
    		•  The BioGRID Database Seperator Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRF1
  • YDR223W
    		•  The BioGRID Database Seperator Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRC1
  • YML033W
  • HEH1
  • YML034W
    		•  The BioGRID Database Seperator Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFG1
  • YOR315W
    		•  The BioGRID Database Seperator Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TGL5
  • STC2
  • YOR081C
    		•  The BioGRID Database Seperator Triacylglycerol lipase involved in TAG mobilization; localizes to lipid particles; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BOP3
  • YNL042W
    		•  The BioGRID Database Seperator Protein of unknown function, potential Cdc28p substrate; overproduction suppresses a pam1 slv3 double null mutation and confers resistance to methylmercury
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STB1
  • YNL309W
    		•  The BioGRID Database Seperator Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLD2
  • DRC1
  • YKL108W
    		•  The BioGRID Database Seperator Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS2
  • MMC1
  • YGL075C
    		•  The BioGRID Database Seperator Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIN2
  • YOR104W
    		•  The BioGRID Database Seperator Protein that induces appearance of [PIN+] prion when overproduced
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CST9
  • ZIP3
  • YLR394W
    		•  The BioGRID Database Seperator SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS4
  • SLX2
  • YBR100W
  • YBR098W
    		•  The BioGRID Database Seperator Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSC3
  • YLR219W
    		•  The BioGRID Database Seperator Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YOL036W
  • YOL036W
    		•  The BioGRID Database Seperator Protein of unknown function; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP60
  • YAR002W
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRM1
  • MTR1
  • PRP20
  • YGL097W
    		•  The BioGRID Database Seperator Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD6
  • AIP3
  • YLR319C
    		•  The BioGRID Database Seperator Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR035C
  • YGR035C
    		•  The BioGRID Database Seperator Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBF20
  • YPR111W
    		•  The BioGRID Database Seperator Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC7
  • YDR389W
    		•  The BioGRID Database Seperator GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGL235W
  • YGL235W
    		•  The BioGRID Database Seperator Putative protein of unknown function; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STU2
  • YLR045C
    		•  The BioGRID Database Seperator Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHL050C
  • YHL050C
    		•  The BioGRID Database Seperator Putative protein of unknown function, potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHE2
  • YKL130C
    		•  The BioGRID Database Seperator RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAE2
  • COM1
  • YGL175C
    		•  The BioGRID Database Seperator Protein with a role in accurate meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Huertas P (2008) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIN82
  • YCR091W
    		•  The BioGRID Database Seperator Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAL5
  • YJL165C
    		•  The BioGRID Database Seperator Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JSN1
  • PUF1
  • YJR091C
    		•  The BioGRID Database Seperator Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC110
  • NUF1
  • XCM1
  • YDR356W
    		•  The BioGRID Database Seperator Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI5
  • YOR083W
    		•  The BioGRID Database Seperator Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ULP2
  • SMT4
  • YIL031W
    		•  The BioGRID Database Seperator Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIP3
  • YGL216W
    		•  The BioGRID Database Seperator Kinesin-related motor protein involved in mitotic spindle positioning
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FRT2
  • HPH2
  • YAL028W
    		•  The BioGRID Database Seperator Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSB2
  • YGR014W
    		•  The BioGRID Database Seperator Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL1
  • HPR3
  • CDC17
  • CRT5
  • YNL102W
    		•  The BioGRID Database Seperator Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPO11
  • YHL022C
    		•  The BioGRID Database Seperator Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NTH1
  • YDR001C
    		•  The BioGRID Database Seperator Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIT1
  • ARN3
  • YEL065W
    		•  The BioGRID Database Seperator Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNF2
  • YDR093W
    		•  The BioGRID Database Seperator Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAV1
  • SOI3
  • YJR033C
    		•  The BioGRID Database Seperator Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF4
  • TAF48
  • MPT1
  • TSG2
  • YMR005W
    		•  The BioGRID Database Seperator TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AXL2
  • SRO4
  • BUD10
  • YIL140W
    		•  The BioGRID Database Seperator Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EXO84
  • USA3
  • YBR102C
    		•  The BioGRID Database Seperator Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNL058C
  • YNL058C
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUS3
  • YLR401C
    		•  The BioGRID Database Seperator Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RLF2
  • CAC1
  • YPR018W
    		•  The BioGRID Database Seperator Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRR1
  • YKL116C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2
  • STK2
  • YJR059W
    		•  The BioGRID Database Seperator Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPB2
  • YPR175W
    		•  The BioGRID Database Seperator Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RGA2
  • YDR379W
    		•  The BioGRID Database Seperator GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRL3
  • YKR091W
    		•  The BioGRID Database Seperator Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPR174C
  • YPR174C
    		•  The BioGRID Database Seperator Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PXL1
  • YKR090W
    		•  The BioGRID Database Seperator LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BNI1
  • SHE5
  • PPF3
  • YNL271C
    		•  The BioGRID Database Seperator Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNA2
  • WEB2
  • YHR164C
    		•  The BioGRID Database Seperator Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP1
  • YOR098C
    		•  The BioGRID Database Seperator Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KEL2
  • YGR238C
    		•  The BioGRID Database Seperator Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DDC1
  • YPL194W
    		•  The BioGRID Database Seperator DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOS4
  • YLR183C
    		•  The BioGRID Database Seperator Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAF120
  • YNL278W
    		•  The BioGRID Database Seperator Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSA1
  • YOR29-17
  • YOR066W
    		•  The BioGRID Database Seperator Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YRF1-6
  • YRF1
  • YNL339C
    		•  The BioGRID Database Seperator Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator