| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
|
| RPC19 |
YNL113W |
|
RNA polymerase subunit, common to RNA polymerases I and III
|
|
|
|
|
| RPA190 |
RRN1YOR341W |
|
RNA polymerase I subunit; largest subunit of RNA polymerase I
|
|
|
|
|
| RPA135 |
RPA2RRN2SRP3YPR010C |
|
RNA polymerase I subunit A135
|
|
|
|
|
| RPO31 |
RPC160RPC1YOR116C |
|
RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunit
|
|
|
|
|
| RPB5 |
YBR154C |
|
RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
|
|
|
|
|
| RET1 |
PDS2RPC128RPC2YOR207C |
|
Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
|
|
|
|
|
| RPA49 |
YNL248C |
|
RNA polymerase I subunit A49
|
|
|
|
|
| RPC34 |
YNR003C |
|
RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
|
|
|
|
|
| RPC82 |
RPC3YPR190C |
|
RNA polymerase III subunit C82
|
|
|
|
|
| RPA43 |
YOR340C |
|
RNA polymerase I subunit A43
|
|
|
|
|
| RPO26 |
RPB6YPR187W |
|
RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
|
|
|
|
|
| RPC25 |
YKL1YKL144C |
|
RNA polymerase III subunit C25
|
|
|
|
|
| RPB10 |
YOR210W |
|
RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
|
|
|
|
|
| RPC53 |
RPC4YDL150W |
|
RNA polymerase III subunit C53
|
|
|
|
|
| RPC37 |
YKR025W |
|
RNA polymerase III subunit C37
|
|
|
|
|
| RPC31 |
RPC8ACP2YNL151C |
|
RNA polymerase III subunit C31; contains HMG-like C-terminal domain
|
|
|
|
|
| RPA12 |
RRN4YJR063W |
|
RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
|
|
|
|
|
| RPA34 |
YJL148W |
|
RNA polymerase I subunit A34.5
|
|
|
|
|
| RPB8 |
YOR224C |
|
RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
|
|
|
|
|
| RPC17 |
YJL011C |
|
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
|
|
|
|
|
| MAF1 |
YDR005C |
|
Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB
|
|
|
|
|
| SSB2 |
YG103YNL209W |
|
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1
|
|
|
|
|
| SRO7 |
SOP1SNI1YPR032W |
|
Putative effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor
|
|
|
|
|
| RPA14 |
YDR156W |
|
RNA polymerase I subunit A14
|
|
|
|
|
| REB1 |
GRF2YBR049C |
|
RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription
|
|
|
|
|
| DHH1 |
YDL160C |
|
Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation
|
|
|
|
|
| AMS1 |
YGL156W |
|
Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
|
|
|
|
|
| RRP6 |
YOR001W |
|
Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus
|
|
|
|
|
| ARF1 |
YDL192W |
|
ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
|
|
|
|
|
| PPH21 |
PPH1YDL134C |
|
Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
|
|
|
|
|
| KRI1 |
YNL308C |
|
Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p
|
|
|
|
|
| NTG1 |
SCR1FUN33YAL015C |
|
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion
|
|
|
|
|
| SMC4 |
YLR086W |
|
Subunit of the condensin complex, which reorganizes chromosomes during cell division, forms a stable complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity and promotes knotting of circular DNA; potential Cdc28p substrate
|
|
|
|
|
| ARF2 |
YDL137W |
|
ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p
|
|
|
|
|
| URE2 |
YNL229C |
|
Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
|
|
|
|
|
| CDC60 |
YPL160W |
|
Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
|
|
|
|
|
| ILS1 |
YBL076C |
|
Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
|
|
|
|
|
| VMA4 |
YOR332W |
|
Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
|
|
|
|
|
| ARO4 |
YBR249C |
|
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
|
|
|
|
|
| FAR10 |
YLR238W |
|
Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
|
|
|
|
|
| AHA1 |
YDR214W |
|
Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock
|
|
|
|
|
| NAF1 |
YNL124W |
|
Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins
|
|
|
|
|
| NET1 |
ESC5CFI1SRM8YJL076W |
|
Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure
|
|
|
|
|
| VPS3 |
VPT17PEP6VPL3YDR495C |
|
Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
|
|
|
|
|
| SSB1 |
YG101YDL229W |
|
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p
|
|
|
|
|
| HTA2 |
H2A2YBL003C |
|
One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
|
|
|
|
|
| YTA7 |
YGR270W |
|
Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p
|
|
|
|
|
| RPC40 |
RPC5YPR110C |
|
RNA polymerase subunit, common to RNA polymerase I and III
|
|
|
|
|
| KEM1 |
SKI1DST2RAR5YGL173C |
|
Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
|
|
|
|
|
| TRP5 |
YGL026C |
|
Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis
|
|
|
|
|
| SMT3 |
YDR510W |
|
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
|
|
|
|
|
| RPC10 |
RPB12YHR143W-A |
|
RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
|
|
|
|
|
| DIS3 |
RRP44YOL021C |
|
Catalytic component of the exosome, involved in RNA processing and degradation; binds Gsp1p/Ran and enhances the GEF activity of Srm1p; implicated in mitotic control; homologous to the E. coli RNase R of the RNase II family
|
|
|
|
|
| ATG11 |
CVT9YPR049C |
|
Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy)
|
|
|
|
|
| HHF1 |
YBR009C |
|
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
|
|
|
|
|
| SPT5 |
YML010W |
|
Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing
|
|
|
|
|
| GND1 |
YHR183W |
|
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
|
|
|
|
|
| GFA1 |
YKL104C |
|
Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
|
|
|
|
|
| MET18 |
MMS19YIL128W |
|
DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance
|
|
|
|
|
| TSA2 |
YDR453C |
|
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
|
|
|
|
|
| RPN3 |
SUN2YER021W |
|
Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
|
|
|
|
|
| ADH2 |
ADR2YMR303C |
|
Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
|
|
|
|
|
| GCD11 |
SUI4YER025W |
|
Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
|
|
|
|
|
| NGL2 |
YMR285C |
|
Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p
|
|
|
|
|
| GUS1 |
GSN1YGL245W |
|
Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm
|
|
|
|
|
| YER138C |
YER138C |
|
Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
|
|
|
|
|
| MDH1 |
YKL085W |
|
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
|
|
|
|
|
| PYC2 |
YBR218C |
|
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
|
|
|
|
|
| ACC1 |
MTR7ABP2FAS3YNR016C |
|
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
|
|
|
|
|
| YFL042C |
YFL043CYFL042C |
|
Putative protein of unknown function; YFL042C is not an essential gene
|
|
|
|
|
| SEC27 |
YGL137W |
|
Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
|
|
|
|
|
| ISW1 |
SGN2YBR245C |
|
Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation
|
|
|
|
|
| ADR1 |
YDR216W |
|
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
|
|
|
|
|
| IDH2 |
YOR136W |
|
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
|
|
|
|
|
| DOP1 |
YDR141C |
|
Protein of unknown function, essential for viability, involved in establishing cellular polarity and morphogenesis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
|
|
|
|
|
| KAP122 |
PDR6YGL016W |
|
Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance
|
|
|
|
|
| ECM29 |
YHL030W |
|
Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome
|
|
|
|
|
| TBS1 |
YBR150C |
|
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
|
|
|
|
|
| SRY1 |
YKL218C |
|
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
|
|
|
|
|
| RVS167 |
YDR388W |
|
Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin
|
|
|
|
|
| TFP1 |
VMA1CLS8YDL185W |
|
Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
|
|
|
|
|
| ISA2 |
YPR067W |
|
Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
|
|
|
|
|
| PYC1 |
YGL062W |
|
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
|
|
|
|
|
| YHR112C |
YHR112C |
|
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
|
|
|
|
|
| ACH1 |
YBL015W |
|
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
|
|
|
|
|
| PRE9 |
YGR135W |
|
20S proteasome beta-type subunit; the only nonessential 20S subunit
|
|
|
|
|
| UBA3 |
YPR066W |
|
Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
|
|
|
|
|
| RTS1 |
SCS1YOR014W |
|
B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A
|
|
|
|
|
| RAD61 |
YDR014W |
|
Protein of unknown function; mutation confers radiation sensitivity
|
|
|
|
|
| BUB3 |
YOR026W |
|
Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
|
|
|
|
|
| MSH2 |
PMS5YOL090W |
|
Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
|
|
|
|
|
| RTT109 |
KIM2REM50YLL002W |
|
Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition
|
|
|
|
|
| KEX2 |
QDS1VMA45SRB1YNL238W |
|
Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
|
|
|
|
|
| SNF4 |
CAT3SCI1YGL115W |
|
Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis
|
|
|
|
|
| DCC1 |
YCL016C |
|
Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
|
|
|
|
|
| UBP6 |
YFR010W |
|
Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds
|
|
|
|
|
| HO |
YDL227C |
|
Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
|
|
|
|
|
| RAD57 |
YDR004W |
|
Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
|
|
|
|
|
| UBC8 |
GID3YEL012W |
|
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
|
|
|
|
|
| RIF1 |
YBR275C |
|
Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
|
|
|
|
|
| MAD1 |
YGL086W |
|
Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
|
|
|
|
|
| BUD13 |
CWC26YGL174W |
|
Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern
|
|
|
|
|
| YKE2 |
GIM1PFD6YLR200W |
|
Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
|
|
|
|
|
| YKU80 |
HDF2YMR106C |
|
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
|
|
|
|
|
| FUN30 |
YAL019W |
|
Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
|
|
|
|
|
| SLX4 |
YLR135W |
|
Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
|
|
|
|
|
| TIM13 |
YGR181W |
|
Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
|
|
|
|
|
| MCK1 |
YPK1YNL307C |
|
Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
|
|
|
|
|
| ERG5 |
CYP61YMR015C |
|
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
|
|
|
|
|
| KAR9 |
YPL269W |
|
Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
|
|
|
|
|
| NAP1 |
YKR048C |
|
Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus
|
|
|
|
|
| WHI2 |
YOR043W |
|
Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
|
|
|
|
|
| PPH3 |
YDR075W |
|
Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
|
|
|
|
|
| GAL4 |
GAL81YPL248C |
|
DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
|
|
|
|
|
| LSM1 |
SPB8YJL124C |
|
Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
|
|
|
|
|
| TOF2 |
YKR010C |
|
Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1
|
|
|
|
|
| MON2 |
YSL2YNL297C |
|
Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
|
|
|
|
|
| SEC15 |
YGL233W |
|
Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles
|
|
|
|
|
| CLB3 |
YDL155W |
|
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
|
|
|
|
|
| SUR1 |
LPE15CSG1BCL21YPL057C |
|
Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p
|
|
|
|
|
| THP2 |
YHR167W |
|
Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
|
|
|
|
|
| UBC13 |
YDR092W |
|
Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
|
|
|
|
|
| GCR2 |
YNL199C |
|
Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
|
|
|
|
|
| VPS71 |
SWC6YML041C |
|
Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
|
|
|
|
|
| CKB2 |
YOR039W |
|
Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
|
|
|
|
|
| PAC2 |
YER007W |
|
Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
|
|
|
|
|
| XRS2 |
YDR369C |
|
Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
|
|
|
|
|
| SEC18 |
ANU4YBR080C |
|
ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF
|
|
|
|
|
| CDC42 |
YLR229C |
|
Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
|
|
|
|
|
| SRP40 |
YKR092C |
|
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
|
|
|
|
|
| SER2 |
YGR208W |
|
Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
|
|
|
|
|
| BIM1 |
YEB1YER016W |
|
Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
|
|
|
|
|
| SIC1 |
SDB25YLR079W |
|
Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
|
|
|
|
|
| SWC3 |
SWC1YAL011W |
|
Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
|
|
|
|
|
| PSH1 |
YOL054W |
|
Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein
|
|
|
|
|
| RAD27 |
ERC11FEN1RTH1YKL113C |
|
5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
|
|
|
|
|
| MFT1 |
MFT52YML062C |
|
Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
|
|
|
|
|
| NHP6A |
YPR052C |
|
High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
|
|
|
|
|
| HOS1 |
YPR068C |
|
Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex
|
|
|
|
|
| UME6 |
NIM2CAR80RIM16YDR207C |
|
Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
|
|
|
|
|
| UBP2 |
YOR124C |
|
Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C terminus of ubiquitin fusions; capable of cleaving polyubiquitin and possesses isopeptidase activity
|
|
|
|
|
| RPN4 |
UFD5SON1YDL020C |
|
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
|
|
|
|
|
| CSM3 |
YMR048W |
|
Protein required for accurate chromosome segregation during meiosis
|
|
|
|
|
| VAM3 |
PTH1YOR106W |
|
Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins
|
|
|
|
|
| HTL1 |
YCR020W-B |
|
Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
|
|
|
|
|
| SHP1 |
UBX1YBL058W |
|
UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
|
|
|
|
|
| TOP3 |
EDR1YLR234W |
|
DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination
|
|
|
|
|
| RRM3 |
RTT104YHR031C |
|
DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
|
|
|
|
|
| SWI3 |
TYE2YJL176C |
|
Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
|
|
|
|
|
| VPS64 |
FAR9YDR200C |
|
Cytoplasmic protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p, Far7p, Far10p, and Far11p that is involved in pheromone-induced cell cycle arrest; also localized to the endoplasmic reticulum membrane
|
|
|
|
|
