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BioGRID | Network Layout for SEC16 for Saccharomyces cerevisiae
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SEC16

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: LPF1, YPL085W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p|Sec16p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 7 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SEC16

SEC16 was identified with 30 protein interactions and 13 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SEC23
  • YPR181C
    		•  The BioGRID Database Seperator GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p|Sec23p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Espenshade P (1995)
    Two-hybrid
    bait Espenshade P (1995)
    hit Gimeno RE (1996)
    Reconstituted Complex
    hit Supek F (2002)
    Affinity Capture-MS
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Dosage Rescue
    hit Kurihara T (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC24
  • ANU1
  • YIL109C
    		•  The BioGRID Database Seperator Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p|Sec24p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gimeno RE (1996)
    Reconstituted Complex
    bait/hit Gimeno RE (1996)
    hit Supek F (2002)
    Two-hybrid
    bait Gimeno RE (1996)
    Affinity Capture-MS
    bait Gavin AC (2006)
    Dosage Rescue
    hit Kurihara T (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC13
  • ANU3
  • YLR208W
    		•  The BioGRID Database Seperator Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles|Sec13p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Reconstituted Complex
    hit Supek F (2002)
    Synthetic Lethality
    bait Roberg KJ (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC31
  • WEB1
  • YDL195W
    		•  The BioGRID Database Seperator Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation|Sec31p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Shaywitz DA (1997)
    Two-hybrid
    hit Shaywitz DA (1997)
    Reconstituted Complex
    hit Supek F (2002)
    Dosage Lethality
    hit Salama NR (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SED4
  • YCR067C
    		•  The BioGRID Database Seperator Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p|Sed4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gimeno RE (1995)
    Two-hybrid
    bait Gimeno RE (1995)
    Dosage Rescue
    hit Gimeno RE (1995)
    Synthetic Growth Defect
    bait Gimeno RE (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAR1
  • YPL218W
    		•  The BioGRID Database Seperator GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport|Sar1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Supek F (2002)
    Dosage Rescue
    bait Saito Y (1999)
    hit Naka?o A (1989)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFB2
  • YNL049C
    		•  The BioGRID Database Seperator Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy|Sfb2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRE1
  • ERN1
  • YHR079C
    		•  The BioGRID Database Seperator Ire1p|Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Chang HJ (2004)
    Dosage Rescue
    hit Sato M (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL10
  • GRC5
  • QSR1
  • YLR075W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family|Rpl10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAR2
  • GRP78
  • YJL034W
    		•  The BioGRID Database Seperator ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p|Kar2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DMA1
  • CHF1
  • YHR115C
    		•  The BioGRID Database Seperator Dma1p|Protein involved in regulating spindle position and orientation, functionally redundant with Dma2p; homolog of S. pombe Dma1 and H. sapiens Chfr; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Graumann J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG5
  • YPL227C
    		•  The BioGRID Database Seperator Alg5p|UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP14
  • GID6
  • YBR058C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T|Ubp14p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL7A
  • YGL076C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)|Rpl7ap; ncRNA
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMF1
  • IBM1
  • YIL051C
    		•  The BioGRID Database Seperator Mitochondrial protein involved in maintenance of the mitochondrial genome|Mmf1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFB3
  • LST1
  • YHR098C
    		•  The BioGRID Database Seperator Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate|Sfb3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Roberg KJ (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BFR2
  • YDR299W
    		•  The BioGRID Database Seperator Bfr2p|Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Chabane S (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COG1
  • COD3
  • LDB11
  • SEC36
  • YGL223C
    		•  The BioGRID Database Seperator Cog1p|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Ram RJ (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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