| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
 |
| FPR4 |
YLR449W |
 |
Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
|
|
 |
 |
 |
| NOP15 |
YNL110C |
 |
Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
|
|
 |
 |
 |
| PIH1 |
NOP17YHR034C |
 |
Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)
|
|
 |
 |
 |
| RIX1 |
IPI2YHR197W |
 |
Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
|
|
 |
 |
 |
| PAP2 |
TRF4YOL115W |
 |
Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase
|
|
 |
 |
 |
| NUG1 |
YER006W |
 |
GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
|
|
 |
 |
 |
| TPK3 |
YKL166C |
 |
cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p
|
|
 |
 |
 |
| YCK2 |
YNL154C |
 |
Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
|
|
 |
 |
 |
| YCK1 |
CKI2YHR135C |
 |
Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p
|
|
 |
 |
 |
| TPK1 |
SRA3PKA1YJL164C |
 |
cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
|
|
 |
 |
 |
| PHO80 |
VAC5AGS3TUP7YOL001W |
 |
Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
|
|
 |
 |
 |
| CMK1 |
YFR014C |
 |
Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II
|
|
 |
 |
 |
| FUS3 |
DAC2YBL016W |
 |
Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
|
|
 |
 |
 |
| PCL1 |
HCS26YNL289W |
 |
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
|
|
 |
 |
 |
| RPL3 |
MAK8YOR29-14TCM1YOR063W |
 |
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
|
|
 |
 |
 |
| SNF1 |
CAT1PAS14HAF3YDR477W |
 |
AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
|
|
 |
 |
 |
| FPR3 |
NPI46YML074C |
 |
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
|
|
 |
 |
 |
| RRN3 |
YKL125W |
 |
Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA
|
|
 |
 |
 |
| MIF2 |
YKL089W |
 |
Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p
|
|
 |
 |
 |
| RRP6 |
YOR001W |
 |
Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus
|
|
 |
 |
 |
| RRP43 |
YCR035C |
 |
Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA
|
|
 |
 |
 |
| NOP58 |
NOP5YOR310C |
 |
Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
|
|
 |
 |
 |
| RSP5 |
UBY1SMM1MUT2YER125W |
 |
Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain
|
|
 |
 |
 |
| RPS7B |
YNL096C |
 |
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
|
|
 |
 |
 |
| CBF5 |
YLR175W |
 |
Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2
|
|
 |
 |
 |
| ATG1 |
CVT10APG1AUT3YGL180W |
 |
Protein serine/threonine kinase, required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; forms a complex with Atg13p and Atg17p
|
|
 |
 |
 |
| PRP43 |
YGL120C |
 |
RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
|
|
 |
 |
 |
| RPS22A |
RPS24YJL190C |
 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
|
|
 |
 |
 |
| NOP2 |
YNA1YNL061W |
 |
Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
|
|
 |
 |
 |
| HSC82 |
HSP90YMR186W |
 |
Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
|
|
 |
 |
 |
| NUP116 |
NSP116YMR047C |
 |
Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p
|
|
 |
 |
 |
| SAW1 |
YAL027W |
 |
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene
|
|
 |
 |
 |
| OAF1 |
YAF1YAL051W |
 |
Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
|
|
 |
 |
 |
| YCR043C |
YCR043C |
 |
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
|
|
 |
 |
 |
| NIP7 |
YPL211W |
 |
Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
|
|
 |
 |
 |
| PRP9 |
YDL030W |
 |
Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
|
|
 |
 |
 |
| ARX1 |
YDR101C |
 |
Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
|
|
 |
 |
 |
| NOG1 |
YPL093W |
 |
Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
|
|
 |
 |
 |
| CIC1 |
NSA3YHR052W |
 |
Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
|
|
 |
 |
 |
| SDA1 |
YGR245C |
 |
Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
|
|
 |
 |
 |
| TSR1 |
YDL060W |
 |
Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles
|
|
 |
 |
 |
| NSE4 |
QRI2YDL105W |
 |
Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex
|
|
 |
 |
 |
| CPR1 |
CPH1CYP1YDR155C |
 |
Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
|
|
 |
 |
 |
| EBP2 |
YKL172W |
 |
Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles
|
|
 |
 |
 |
| STM1 |
MPT4YLR150W |
 |
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
|
|
 |
 |
 |
| SGV1 |
BUR1YPR161C |
 |
Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p, which is the largest subunit of RNA polymerase II; regulated by Cak1p
|
|
 |
 |
 |
| RAD1 |
LPB9YPL022W |
 |
Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
|
|
 |
 |
 |
| ASE1 |
YOR29-09YOR058C |
 |
Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate
|
|
 |
 |
 |
| ESF1 |
YDR365C |
 |
Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
|
|
 |
 |
 |
| UTP22 |
YGR090W |
 |
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
|
|
 |
 |
 |
| MTR4 |
DOB1YJL050W |
 |
Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA
|
|
 |
 |
 |
| TSR2 |
YLR435W |
 |
Protein with a potential role in pre-rRNA processing
|
|
 |
 |
 |
| DPB2 |
YPR175W |
 |
Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
|
|
 |
 |
 |