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BioGRID | Network Layout for RAD53 for Saccharomyces cerevisiae
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RAD53

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: MEC2, SPK1, LSD1, YPL153C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 20 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RAD53

RAD53 was identified with 173 protein interactions and 284 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 RAD9
  • YDR217C
    		•  The BioGRID Database Seperator DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Schwartz MF (2002) [1]
    hit Lee SJ (2003) [5]
    bait Gilbert CS (2001) [1]
    Two-hybrid
    bait Leroy C (2003) [4]
    bait/hit Sun Z (1998) [3]
    Affinity Capture-Western
    hit Naiki T (2004) [2]
    hit Sun Z (1998) [3]
    hit Giannattasio M (2002) [1]
    bait Emili A (1998) [1]
    hit Usui T (2001) [3]
    bait Schwartz MF () [3]
    hit Smolka MB (2006) [34]
    hit Jia-Lin Ma N (2008) [4]
    hit Vidanes GM (2010) [4]
    Protein-peptide
    hit Yuan C (2001) [1]
    hit Wang P (2000) [1]
    Affinity Capture-MS
    hit Nedelcheva MN (2005) [19]
    hit Smolka MB (2006) [34]
    Biochemical Activity
    hit Lee SJ (2003) [5]
    bait Usui T (2009) [2]
    Co-purification
    hit Vialard JE (1998) [1]
    Phenotypic Enhancement
    hit Paulovich AG (1997) [4]
    Synthetic Growth Defect
    bait/hit Pike BL (2004) [5]
    bait/hit Pike BL (2004) [7]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASF1
  • CIA1
  • YJL115W
    		•  The BioGRID Database Seperator Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    hit Nedelcheva MN (2005) [19]
    bait Krogan NJ (2006) [7079]
    bait Green EM (2005) [7]
    hit Smolka MB (2006) [34]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    bait/hit Emili A (2001) [3]
    bait/hit Hu F (2001) [22]
    bait/hit Schwartz MF () [3]
    Synthetic Rescue
    bait Ramey CJ (2004) [7]
    Synthetic Growth Defect
    bait Ramey CJ (2004) [7]
    hit Pan X (2006) [5331]
    Phenotypic Enhancement
    bait Kats ES (2006) [11]
    Dosage Rescue
    hit Usui T (2007) [5]
    hit Hu F (2001) [22]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEC1
  • ESR1
  • SAD3
  • YBR136W
    		•  The BioGRID Database Seperator Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lee SJ (2004) [2]
    hit Chen SH (2009) [14]
    Biochemical Activity
    bait Sweeney FD (2005) [1]
    bait Lee SJ (2003) [5]
    bait Ma JL (2006) [1]
    bait Navadgi-Patil VM (2008) [4]
    hit Chen SH (2009) [14]
    Synthetic Lethality
    bait Zhao X (2001) [4]
    Phenotypic Enhancement
    bait Clerici M (2004) [4]
    Dosage Rescue
    bait Fasullo M (2008) [2]
    Synthetic Rescue
    bait/hit Zhao X (2001) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SML1
  • YML058W
    		•  The BioGRID Database Seperator Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Chen SH (2009) [14]
    Biochemical Activity
    bait Chen SH (2009) [14]
    Phenotypic Enhancement
    hit Myung K (2002) [33]
    hit Myung K (2001) [4]
    hit Fasullo M (2005) [3]
    bait Lebedeva MA (2007) [3]
    bait Makovets S (2009) [3]
    Synthetic Rescue
    hit Zhao X (2002) [6]
    hit Zhao X (1998) [8]
    hit Gunjan A (2003) [13]
    hit Curcio MJ (2007) [43]
    Synthetic Growth Defect
    hit Gunjan A (2003) [13]
    Phenotypic Suppression
    hit Fiorani S (2008) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUN1
  • YDL101C
    		•  The BioGRID Database Seperator Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    Affinity Capture-Western
    bait Bashkirov VI (2003) [3]
    bait Lee SJ (2003) [5]
    Reconstituted Complex
    hit Bashkirov VI (2003) [3]
    Biochemical Activity
    hit Bashkirov VI (2003) [3]
    bait Chen SH (2009) [14]
    Protein-peptide
    bait Lee H (2008) [1]
    Dosage Rescue
    hit Hu F (2001) [22]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRC1
  • YCL060C
  • YCL061C
    		•  The BioGRID Database Seperator S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    Affinity Capture-Western
    hit Smolka MB (2006) [34]
    bait Chen SH (2009) [14]
    Biochemical Activity
    bait Chen SH (2009) [14]
    Synthetic Lethality
    bait Hu F (2001) [22]
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Synthetic Rescue
    bait Tsolou A (2007) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD53
  • MEC2
  • SPK1
  • LSD1
  • YPL153C
    		•  The BioGRID Database Seperator Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
    Gene Ontology: [View List]
    Biochemical Activity
    hit Lee SJ (2003) [5]
    hit Chen SH (2009) [14]
    hit Janke R (2010) [2]
    Affinity Capture-Western
    hit Jia-Lin Ma N (2008) [4]
    Reconstituted Complex
    hit Jia-Lin Ma N (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGS1
  • YMR190C
    		•  The BioGRID Database Seperator Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes
    Gene Ontology: [View List]
    Co-localization
    bait Frei C (2000) [3]
    Affinity Capture-Western
    hit Bjergbaek L (2005) [7]
    Two-hybrid
    bait Bjergbaek L (2005) [7]
    Phenotypic Enhancement
    hit Myung K (2002) [33]
    bait Putnam CD (2009) [35]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBF4
  • DNA52
  • LSD7
  • YDR052C
    		•  The BioGRID Database Seperator Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Duncker BP (2002) [9]
    Two-hybrid
    bait Duncker BP (2002) [9]
    hit Dohrmann PR (1999) [5]
    bait Varrin AE (2005) [4]
    Synthetic Lethality
    bait Gabrielse C (2006) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTC2
  • YER089C
    		•  The BioGRID Database Seperator Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Smolka MB (2006) [34]
    Two-hybrid
    bait Leroy C (2003) [4]
    bait Guillemain G (2007) [2]
    Dosage Rescue
    hit Marsolier MC (2000) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC13
  • EST4
  • YDL220C
    		•  The BioGRID Database Seperator Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    Synthetic Rescue
    bait Grandin N (2001) [5]
    bait Liang F (2007) [7]
    bait Tsolou A (2007) [10]
    bait Grandin N (2008) [21]
    Synthetic Growth Defect
    bait Grandin N (2008) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT2
  • YNL031C
    		•  The BioGRID Database Seperator One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
    Gene Ontology: [View List]
    Biochemical Activity
    hit Singh RK (2009) [15]
    Affinity Capture-Western
    hit Singh RK (2009) [15]
    Synthetic Rescue
    hit Gunjan A (2003) [13]
    hit Dohrmann PR (2006) [5]
    hit Reis CC (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC5
  • PKX2
  • MSD2
  • YMR001C
    		•  The BioGRID Database Seperator Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Vidanes GM (2010) [4]
    bait Donnianni RA (2010) [4]
    Biochemical Activity
    bait Vidanes GM (2010) [4]
    Dosage Rescue
    bait Pellicioli A (2001) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT1
  • SIN2
  • BUR5
  • YBR010W
    		•  The BioGRID Database Seperator One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Gunjan A (2003) [13]
    hit Singh RK (2009) [15]
    Biochemical Activity
    hit Singh RK (2009) [15]
    Dosage Lethality
    hit Gunjan A (2003) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI6
  • PSL8
  • SDS11
  • YLR182W
    		•  The BioGRID Database Seperator Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Sidorova JM (2003) [1]
    hit Sidorova JM (1997) [1]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSY2
  • YNL201C
    		•  The BioGRID Database Seperator Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus
    Gene Ontology: [View List]
    Two-hybrid
    bait Gingras AC (2005) [75]
    bait O'Neill BM (2007) [20]
    Biochemical Activity
    bait O'Neill BM (2007) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELG1
  • RTT110
  • YOR144C
    		•  The BioGRID Database Seperator Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Banerjee S (2004) [17]
    Synthetic Lethality
    bait Bellaoui M (2003) [57]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Phenotypic Suppression
    hit Curcio MJ (2007) [43]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD55
  • YDR076W
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Herzberg K (2006) [8]
    Two-hybrid
    bait Herzberg K (2006) [8]
    Phenotypic Suppression
    hit Curcio MJ (2007) [43]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI4
  • ART1
  • YER111C
    		•  The BioGRID Database Seperator DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Smolka MB (2006) [34]
    Dosage Lethality
    hit Sidorova JM (2002) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC7
  • SAS1
  • LSD6
  • YDL017W
    		•  The BioGRID Database Seperator DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ogi H (2008) [1]
    Synthetic Lethality
    bait Dohrmann PR (1999) [5]
    bait Dohrmann PR (2006) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC10
  • YCR002C
    		•  The BioGRID Database Seperator Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    Affinity Capture-Western
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRP1
  • KAP60
  • SCM1
  • YNL189W
    		•  The BioGRID Database Seperator Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHS1
  • SEP7
  • YDL225W
    		•  The BioGRID Database Seperator One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    Affinity Capture-Western
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC11
  • PSL9
  • YJR076C
    		•  The BioGRID Database Seperator Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    Affinity Capture-Western
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIN4
  • MDT1
  • YBL051C
    		•  The BioGRID Database Seperator Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
    Gene Ontology: [View List]
    Two-hybrid
    bait Pike BL (2004) [5]
    Affinity Capture-Western
    hit Pike BL (2004) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YTA7
  • YGR270W
    		•  The BioGRID Database Seperator Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAP95
  • RSL1
  • YLR347C
    		•  The BioGRID Database Seperator Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFC5
  • YBR087W
    		•  The BioGRID Database Seperator Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
    Gene Ontology: [View List]
    Dosage Rescue
    bait Sugimoto K (1997) [2]
    bait Sugimoto K (1996) [2]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF2
  • YNL030W
    		•  The BioGRID Database Seperator One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Gunjan A (2003) [13]
    hit Dohrmann PR (2006) [5]
    hit Reis CC (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRI1
  • YIR008C
    		•  The BioGRID Database Seperator Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Synthetic Lethality
    bait Marini F (1997) [4]
    Phenotypic Suppression
    hit Marini F (1997) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDS1
  • YDR113C
    		•  The BioGRID Database Seperator Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Zhu Y (2001) [2]
    hit Fasullo M (2005) [3]
    Synthetic Rescue
    bait Gardner R (1999) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEL1
  • YBL088C
    		•  The BioGRID Database Seperator Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene
    Gene Ontology: [View List]
    Dosage Lethality
    hit Viscardi V (2003) [3]
    Phenotypic Enhancement
    hit Myung K (2002) [33]
    bait Longhese MP (2000) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD17
  • YOR368W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Paulovich AG (1997) [4]
    Synthetic Growth Defect
    hit Pike BL (2004) [7]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH2
  • SCD3
  • YDR099W
    		•  The BioGRID Database Seperator 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Usui T (2007) [5]
    Dosage Rescue
    hit Usui T (2007) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPH3
  • YDR075W
    		•  The BioGRID Database Seperator Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
    Gene Ontology: [View List]
    Biochemical Activity
    bait O'Neill BM (2007) [20]
    Phenotypic Suppression
    bait Szyjka SJ (2008) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MUS81
  • SLX3
  • YDR386W
    		•  The BioGRID Database Seperator Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAA1
  • YDR071C
    		•  The BioGRID Database Seperator Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    Synthetic Growth Defect
    bait Liu B (2005) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DDC1
  • YPL194W
    		•  The BioGRID Database Seperator DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Navadgi-Patil VM (2009) [1]
    Synthetic Growth Defect
    hit Pike BL (2004) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLA4
  • ERC10
  • YNL298W
    		•  The BioGRID Database Seperator Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    Synthetic Growth Defect
    hit Enserink JM (2006) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD24
  • YER173W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Paulovich AG (1997) [4]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFX1
  • CRT1
  • YLR176C
    		•  The BioGRID Database Seperator Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins
    Gene Ontology: [View List]
    Dosage Lethality
    hit Huang M (1998) [9]
    Synthetic Rescue
    hit Huang M (1998) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM10
  • DNA43
  • YIL150C
    		•  The BioGRID Database Seperator Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Kawasaki Y (2000) [13]
    Synthetic Lethality
    bait Lee C (2010) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM3
  • PFD4
  • YNL153C
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT8
  • YLR055C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT3
  • YDR392W
    		•  The BioGRID Database Seperator Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IES2
  • YNL215W
    		•  The BioGRID Database Seperator Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOF1
  • YNL273W
    		•  The BioGRID Database Seperator Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAF9
  • YNL107W
    		•  The BioGRID Database Seperator Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LOS1
  • YKL205W
    		•  The BioGRID Database Seperator Nuclear pore protein involved in nuclear export of pre-tRNA
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Ghavidel A (2007) [2]
    Phenotypic Enhancement
    hit Ghavidel A (2007) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Dosage Rescue
    hit Usui T (2007) [5]
    Synthetic Rescue
    bait Grandin N (2008) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HPC2
  • YBR215W
    		•  The BioGRID Database Seperator Highly charged, basic protein required for normal cell-cycle regulation of histone gene transcription; mutants display strong synthetic defects with subunits of FACT, a complex that allows RNA Pol II to elongate through nucleosomes
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM5
  • PFD5
  • YML094W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB5
  • YPR120C
    		•  The BioGRID Database Seperator B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Gibson DG (2004) [4]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC6
  • YJL194W
    		•  The BioGRID Database Seperator Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p
    Gene Ontology: [View List]
    Dosage Lethality
    hit Green BM (2005) [3]
    Synthetic Lethality
    bait Archambault V (2005) [64]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNR1
  • CRT7
  • RIR1
  • SDS12
  • YER070W
    		•  The BioGRID Database Seperator Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
    Gene Ontology: [View List]
    Dosage Rescue
    hit Hu F (2001) [22]
    hit Desany BA (1998) [28]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHD1
  • YER164W
    		•  The BioGRID Database Seperator Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Synthetic Rescue
    hit Biswas D (2008) [28]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKB2
  • YOR039W
    		•  The BioGRID Database Seperator Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF5
  • YEL018W
    		•  The BioGRID Database Seperator Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIA2
  • YOR29-31
  • YOR080W
    		•  The BioGRID Database Seperator Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Synthetic Lethality
    bait Blake D (2006) [61]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     XRS2
  • YDR369C
    		•  The BioGRID Database Seperator Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit D'Amours D (2001) [1]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA1
  • UFD3
  • ZZZ4
  • YKL213C
    		•  The BioGRID Database Seperator WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNL284C-A
  • YNL284C-A
    		•  The BioGRID Database Seperator Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR210C
  • YGR210C
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR034C-C
  • YDR034C-C
    		•  The BioGRID Database Seperator Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AIM3
  • YBR108W
    		•  The BioGRID Database Seperator Protein interacting with Rsv167p; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP10
  • DOT4
  • YNL186W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARC1
  • YGL105W
    		•  The BioGRID Database Seperator Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FRT2
  • HPH2
  • YAL028W
    		•  The BioGRID Database Seperator Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHE3
  • YBR130C
    		•  The BioGRID Database Seperator Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPR091C
  • YPR091C
    		•  The BioGRID Database Seperator Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YLR257W
  • YLR257W
    		•  The BioGRID Database Seperator Putative protein of unknown function
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADK1
  • AKY2
  • AKY1
  • YDR226W
    		•  The BioGRID Database Seperator Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSD1
  • CLA1
  • MCS1
  • SRK1
  • YDR293C
    		•  The BioGRID Database Seperator Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR266C
  • YDR266C
    		•  The BioGRID Database Seperator Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GUS1
  • GSN1
  • YGL245W
    		•  The BioGRID Database Seperator Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALY2
  • YJL084C
    		•  The BioGRID Database Seperator Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPR013C
  • YPR013C
    		•  The BioGRID Database Seperator Putative zinc finger protein; YPR013C is not an essential gene
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TBF1
  • LPI16
  • YPL128C
    		•  The BioGRID Database Seperator Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GID8
  • DCR1
  • YMR135C
    		•  The BioGRID Database Seperator Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNH70
  • RNA82
  • REX1
  • YGR276C
    		•  The BioGRID Database Seperator 3' exoribonuclease, required for 5S rRNA and tRNA-Arg3 maturation
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IPP1
  • PPA1
  • YBR011C
    		•  The BioGRID Database Seperator Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDH1
  • YKL085W
    		•  The BioGRID Database Seperator Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA2
  • H2A2
  • YBL003C
    		•  The BioGRID Database Seperator One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EDE1
  • BUD15
  • YBL047C
    		•  The BioGRID Database Seperator Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UTP22
  • YGR090W
    		•  The BioGRID Database Seperator Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMC3
  • YJL074C
    		•  The BioGRID Database Seperator Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF1
  • YBR009C
    		•  The BioGRID Database Seperator One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Gunjan A (2003) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA1
  • YBL007C
    		•  The BioGRID Database Seperator Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP9
  • YER098W
    		•  The BioGRID Database Seperator Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SES1
  • YDR023W
    		•  The BioGRID Database Seperator Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YER064C
  • YER064C
    		•  The BioGRID Database Seperator Non-essential nuclear protein; null mutation has global effects on transcription
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMO1
  • HSM2
  • YDR174W
    		•  The BioGRID Database Seperator Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM5
  • CDC46
  • BOB1
  • YLR274W
    		•  The BioGRID Database Seperator Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOM1
  • YDR457W
    		•  The BioGRID Database Seperator E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Singh RK (2009) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AMD1
  • AMD3
  • YML035C
    		•  The BioGRID Database Seperator AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CST6
  • ACA2
  • SHF1
  • YIL036W
    		•  The BioGRID Database Seperator Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLN3
  • YER040W
    		•  The BioGRID Database Seperator Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NET1
  • ESC5
  • CFI1
  • SRM8
  • YJL076W
    		•  The BioGRID Database Seperator Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM16
  • DHR1
  • YMR128W
    		•  The BioGRID Database Seperator Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI5
  • YOR083W
    		•  The BioGRID Database Seperator Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RCK2
  • CLK1
  • CMK3
  • YLR248W
    		•  The BioGRID Database Seperator Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC2
  • YNL272C
    		•  The BioGRID Database Seperator Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD3
  • YCL012W
  • YCL014W
    		•  The BioGRID Database Seperator Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD4
  • YJR092W
    		•  The BioGRID Database Seperator Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC4
  • YBR082C
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Singh RK (2009) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IFH1
  • YLR223C
    		•  The BioGRID Database Seperator Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAS10
  • UTP3
  • YDL153C
    		•  The BioGRID Database Seperator Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PBS2
  • SFS4
  • SSK4
  • HOG4
  • YJL128C
    		•  The BioGRID Database Seperator MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCL1
  • TRM4
  • YBL024W
    		•  The BioGRID Database Seperator S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC12
  • CLA10
  • PSL7
  • YHR107C
    		•  The BioGRID Database Seperator Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC3
  • YLR314C
    		•  The BioGRID Database Seperator Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESC1
  • YMR219W
    		•  The BioGRID Database Seperator Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRC1
  • YML033W
  • HEH1
  • YML034W
    		•  The BioGRID Database Seperator Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD14
  • YAR014C
    		•  The BioGRID Database Seperator Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VHS2
  • YIL135C
    		•  The BioGRID Database Seperator Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LAS17
  • BEE1
  • YOR181W
    		•  The BioGRID Database Seperator Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OSH2
  • YDL019C
    		•  The BioGRID Database Seperator Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP1
  • YOR098C
    		•  The BioGRID Database Seperator Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Smolka MB (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP60
  • YAR002W
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
    Gene Ontology: [View List]
    Biochemical Activity
    hit Smolka MB (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP2
  • YLR335W
    		•  The BioGRID Database Seperator Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
    Gene Ontology: [View List]
    Biochemical Activity
    hit Smolka MB (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHO1
  • YPL127C
    		•  The BioGRID Database Seperator Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation
    Gene Ontology: [View List]
    Biochemical Activity
    hit Jia-Lin Ma N (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLO3
  • YER122C
    		•  The BioGRID Database Seperator ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FYV8
  • YGR196C
    		•  The BioGRID Database Seperator Protein of unknown function, required for survival upon exposure to K1 killer toxin
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MBP1
  • YDL056W
    		•  The BioGRID Database Seperator Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MNR2
  • YKL064W
    		•  The BioGRID Database Seperator Putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRP1
  • YHR146W
    		•  The BioGRID Database Seperator Protein that binds to cruciform DNA structures
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Smolka MB (2006) [34]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPL150W
  • YPL150W
    		•  The BioGRID Database Seperator Putative protein kinase of unknown cellular role
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM7
  • YNL147W
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP133
  • RAT3
  • YKR082W
    		•  The BioGRID Database Seperator Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     THP1
  • BUD29
  • YOL072W
    		•  The BioGRID Database Seperator Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD51
  • MUT5
  • YER095W
    		•  The BioGRID Database Seperator Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Fasullo M (2005) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WTM2
  • YOR229W
    		•  The BioGRID Database Seperator Transcriptional repressor involved in regulation of meiosis and silencing; contains WD repeats
    Gene Ontology: [View List]
    Dosage Rescue
    hit Usui T (2007) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEC3
  • PSO9
  • PIP3
  • YLR288C
    		•  The BioGRID Database Seperator DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEM1
  • DSS1
  • HOD1
  • YDR363W-A
    		•  The BioGRID Database Seperator Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP8
  • YMR223W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFA1
  • BUF2
  • FUN3
  • RPA1
  • YAR007C
    		•  The BioGRID Database Seperator Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAP2
  • TRF4
  • YOL115W
    		•  The BioGRID Database Seperator Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Reis CC (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNU66
  • YOR308C
    		•  The BioGRID Database Seperator Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; has homology to human SART-1 and to an S. pombe protein; snu66 null mutation confers cold-sensitivity but is not lethal at normal growth temperatures
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAC2
  • YML102W
    		•  The BioGRID Database Seperator Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Game JC (1999) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT4
  • YGR063C
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL30
  • YBR088C
    		•  The BioGRID Database Seperator Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RLF2
  • CAC1
  • YPR018W
    		•  The BioGRID Database Seperator Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Kats ES (2006) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator