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BioGRID | Network Layout for REV3 for Saccharomyces cerevisiae
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REV3

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: PSO1, YPL167C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with REV3

REV3 was identified with 12 protein interactions and 130 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 REV7
  • YIL139C
    		•  The BioGRID Database Seperator Processivity subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Nelson JR (1996) [1]
    hit Sabbioneda S (2005) [10]
    bait Hirano Y (2006) [3]
    hit Acharya N (2006) [4]
    Co-purification
    hit Guo D (2001) [1]
    hit Stone JE (2009) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD30
  • DBH1
  • YDR419W
    		•  The BioGRID Database Seperator DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait McDonald JP (1997) [3]
    bait Zhao B (2004) [2]
    bait Gibbs PE (2005) [2]
    hit Sakamoto AN (2007) [2]
    bait Plosky BS (2008) [2]
    hit Yang Y (2008) [2]
    hit O'Brien TJ (2009) [1]
    bait Kats ES (2009) [9]
    Phenotypic Suppression
    hit Abdulovic AL (2007) [4]
    Synthetic Growth Defect
    hit Abdulovic AL (2006) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD52
  • YML032C
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Henriques JA (1981) [6]
    bait O'Brien TJ (2002) [1]
    hit Chen CC (2006) [8]
    hit Endo K (2007) [1]
    Synthetic Rescue
    bait Huang ME (2002) [13]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    bait Conde F (2008) [15]
    Synthetic Lethality
    hit Ball LG (2009) [18]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS2
  • YGL087C
    		•  The BioGRID Database Seperator Protein involved in error-free postreplication DNA repair; forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Broomfield S (2002) [7]
    hit Broomfield S (1998) [1]
    bait Xiao W (1999) [1]
    bait Pastushok L (2007) [1]
    Synthetic Rescue
    bait Huang ME (2002) [13]
    Synthetic Growth Defect
    bait Barbour L (2006) [7]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD55
  • YDR076W
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    bait Herzberg K (2006) [8]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Lethality
    hit Ball LG (2009) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD51
  • MUT5
  • YER095W
    		•  The BioGRID Database Seperator Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Phenotypic Enhancement
    hit Grossmann KF (2001) [3]
    Synthetic Lethality
    hit Ball LG (2009) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD1
  • LPB9
  • YPL022W
    		•  The BioGRID Database Seperator Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Huang ME (2002) [13]
    bait Roche H (1994) [1]
    Phenotypic Suppression
    bait Minesinger BK (2005) [6]
    hit Abdulovic AL (2007) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD57
  • YDR004W
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Synthetic Lethality
    hit Ball LG (2009) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REV1
  • YOR346W
    		•  The BioGRID Database Seperator Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Hirano Y (2006) [3]
    bait/hit Acharya N (2006) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD5
  • REV2
  • SNM2
  • YLR032W
    		•  The BioGRID Database Seperator DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; contains RING finger domain
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Huang ME (2002) [13]
    Synthetic Lethality
    hit Hishida T (2006) [11]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC13
  • YDR092W
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Brusky J (2000) [1]
    hit Xiao W (2000) [7]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAG1
  • MMS5
  • YER142C
    		•  The BioGRID Database Seperator 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Hendricks CA (2002) [2]
    bait Johnson RE (2007) [5]
    Synthetic Rescue
    hit Monti P (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD18
  • YCR066W
    		•  The BioGRID Database Seperator Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Huang ME (2002) [13]
    Phenotypic Suppression
    bait Minesinger BK (2005) [6]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD6
  • UBC2
  • PSO8
  • YGL058W
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Cejka P (2001) [1]
    Synthetic Rescue
    bait Huang ME (2002) [13]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APN1
  • YKL114C
    		•  The BioGRID Database Seperator Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Swanson RL (1999) [8]
    Phenotypic Suppression
    hit Kim N (2009) [9]
    bait Xiao W (2001) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD14
  • YMR201C
    		•  The BioGRID Database Seperator Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Xie Z (2003) [2]
    bait Guo D (2004) [2]
    Synthetic Rescue
    hit Monti P (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EXO1
  • DHS1
  • YOR033C
    		•  The BioGRID Database Seperator 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Synthetic Rescue
    bait Tran PT (2001) [4]
    Synthetic Growth Defect
    bait Tran PT (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX4
  • YLR135W
    		•  The BioGRID Database Seperator Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Flott S (2007) [7]
    Phenotypic Suppression
    bait Flott S (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL1
  • HPR3
  • CDC17
  • CRT5
  • YNL102W
    		•  The BioGRID Database Seperator Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Northam MR (2006) [8]
    bait Suzuki M (2009) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKU70
  • HDF1
  • NES24
  • YMR284W
    		•  The BioGRID Database Seperator Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chen CC (2006) [8]
    Phenotypic Enhancement
    bait Lee K (2007) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD54
  • XRS1
  • YGL163C
    		•  The BioGRID Database Seperator DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Ball LG (2009) [18]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD50
  • YNL250W
    		•  The BioGRID Database Seperator Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Phenotypic Enhancement
    bait Gangavarapu V (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NTG1
  • SCR1
  • FUN33
  • YAL015C
    		•  The BioGRID Database Seperator DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Swanson RL (1999) [8]
    Phenotypic Suppression
    hit Kim N (2009) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL3
  • HPR6
  • CDC2
  • TEX1
  • YDL102W
    		•  The BioGRID Database Seperator Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Pavlov YI (2001) [1]
    bait Northam MR (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPH1
  • YIR002C
    		•  The BioGRID Database Seperator Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Scheller J (2000) [9]
    Phenotypic Enhancement
    hit Schuerer KA (2004) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NTG2
  • SCR2
  • YOL043C
    		•  The BioGRID Database Seperator DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Swanson RL (1999) [8]
    Phenotypic Suppression
    hit Kim N (2009) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSB1
  • YG101
  • YDL229W
    		•  The BioGRID Database Seperator Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gong Y (2009) [1420]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA1
  • YG100
  • YAL005C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gong Y (2009) [1420]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF1
  • TAF130
  • TAF145
  • YGR274C
    		•  The BioGRID Database Seperator TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA2
  • YG102
  • YLL024C
    		•  The BioGRID Database Seperator ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gong Y (2009) [1420]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKU80
  • HDF2
  • YMR106C
    		•  The BioGRID Database Seperator Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Halas A (2009) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA6
  • YLR447C
    		•  The BioGRID Database Seperator Subunit D of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Liao C (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF14
  • SWP29
  • TFG3
  • ANC1
  • YPL129W
    		•  The BioGRID Database Seperator Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Erlich RL (2008) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     XRS2
  • YDR369C
    		•  The BioGRID Database Seperator Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Gangavarapu V (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC7
  • SAS1
  • LSD6
  • YDL017W
    		•  The BioGRID Database Seperator DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Pessoa-Brandao L (2004) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAC2
  • YML102W
    		•  The BioGRID Database Seperator Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Game JC (1999) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIZ1
  • ULL1
  • YDR409W
    		•  The BioGRID Database Seperator SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Stelter P (2003) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOT1
  • PCH1
  • YDR440W
    		•  The BioGRID Database Seperator Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Conde F (2008) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSY3
  • YLR376C
    		•  The BioGRID Database Seperator Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Ball LG (2009) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APN2
  • ETH1
  • YBL019W
    		•  The BioGRID Database Seperator Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Xiao W (2001) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPM1
  • YNL079C
    		•  The BioGRID Database Seperator Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE2
  • SRR2
  • DOA3
  • PRG1
  • YPR103W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit, responsible for the chymotryptic activity of the proteasome
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait McIntyre J (2006) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCH4
  • YOL119C
    		•  The BioGRID Database Seperator Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHE4
  • DIM1
  • YOR035C
    		•  The BioGRID Database Seperator Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEH1
  • GSE2
  • EGO1
  • YKR007W
    		•  The BioGRID Database Seperator Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIM101
  • RIM1
  • YHL027W
    		•  The BioGRID Database Seperator Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPL260W
  • YPL260W
    		•  The BioGRID Database Seperator Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIC1
  • SDB25
  • YLR079W
    		•  The BioGRID Database Seperator Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADR1
  • YDR216W
    		•  The BioGRID Database Seperator Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEI4
  • YER044C-A
    		•  The BioGRID Database Seperator Meiosis-specific protein involved in recombination; required for chromosome synapsis; required for production of viable spores
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLC1
  • SCD4
  • YGR167W
    		•  The BioGRID Database Seperator Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNL4
  • LIG4
  • YOR005C
    		•  The BioGRID Database Seperator DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chen CC (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD17
  • YOR368W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Barbour L (2006) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD24
  • YER173W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Barbour L (2006) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD53
  • MEC2
  • SPK1
  • LSD1
  • YPL153C
    		•  The BioGRID Database Seperator Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Barbour L (2006) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD10
  • YML095C
    		•  The BioGRID Database Seperator Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Chen CC (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD9
  • YDR217C
    		•  The BioGRID Database Seperator DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Barbour L (2006) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUT1
  • YBR252W
    		•  The BioGRID Database Seperator dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Guillet M (2006) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD3
  • REM1
  • YER171W
    		•  The BioGRID Database Seperator 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Henriques JA (1981) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRS2
  • HPR5
  • YJL092W
    		•  The BioGRID Database Seperator DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Broomfield S (2002) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD4
  • YER162C
    		•  The BioGRID Database Seperator Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Hendricks CA (2002) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSM3
  • YBR272C
    		•  The BioGRID Database Seperator Protein of unknown function, involved in DNA mismatch repair during slow growth; has weak similarity to Msh1p
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Fedorova IV (2004) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL2
  • DUN2
  • YNL262W
    		•  The BioGRID Database Seperator Catalytic subunit of DNA polymerase (II) epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Northam MR (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPB3
  • YBR278W
    		•  The BioGRID Database Seperator Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Northam MR (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUB1
  • YGR188C
    		•  The BioGRID Database Seperator Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN5
  • SWI9
  • ADA4
  • YGR252W
    		•  The BioGRID Database Seperator Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HFI1
  • GAN1
  • SRM12
  • SUP110
  • YPL254W
    		•  The BioGRID Database Seperator Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSO2
  • SNM1
  • YMR137C
    		•  The BioGRID Database Seperator Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Grossmann KF (2001) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX8
  • YER116C
    		•  The BioGRID Database Seperator Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MGS1
  • YNL218W
    		•  The BioGRID Database Seperator Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Hishida T (2006) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVB2
  • TIH2
  • TIP49B
  • TIP49
  • YPL235W
    		•  The BioGRID Database Seperator Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF12
  • TAF61
  • TAF68
  • YDR145W
    		•  The BioGRID Database Seperator Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UMP1
  • RNS2
  • YBR173C
    		•  The BioGRID Database Seperator Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait McIntyre J (2006) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.