The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for HSP82 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

HSP82

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: HSP90, YPL240C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 10 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with HSP82

HSP82 was identified with 431 protein interactions and 1840 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 STI1
  • YOR027W
    		•  The BioGRID Database Seperator Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein|Sti1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Richter K (2003)
    hit Mayr C (2000)
    hit Prodromou C (1999)
    hit Catlett MG (2006)
    bait Millson SH (2008)
    Affinity Capture-Western
    hit Liu XD (1999)
    bait/hit Marsh JA (1998)
    bait Flom G (2006)
    hit Chang HC (1994)
    Affinity Capture-MS
    hit Zhao R (2005)
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    Two-hybrid
    hit Millson SH (2005)
    Co-purification
    bait Lotz GP (2003)
    Synthetic Growth Defect
    bait Chang HC (1997)
    hit Flom G (2006)
    bait/hit McClellan AJ (2007)
    Dosage Rescue
    hit Flom G (2006)
    Synthetic Lethality
    hit Flom G (2006)
    hit Zhao R (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AHA1
  • YDR214W
    		•  The BioGRID Database Seperator Aha1p|Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Panaretou B (2002)
    bait Lotz GP (2003)
    Two-hybrid
    hit Panaretou B (2002)
    hit Zhao R (2005)
    hit Millson SH (2005)
    bait/hit Millson SH (2004)
    Affinity Capture-MS
    hit Zhao R (2005)
    bait Gavin AC (2006)
    Reconstituted Complex
    bait Siligardi G (2004)
    bait Meyer P (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR6
  • CYP40
  • YLR216C
    		•  The BioGRID Database Seperator Cpr6p|Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Mayr C (2000)
    hit Prodromou C (1999)
    bait Richter K (2004)
    hit Catlett MG (2006)
    Affinity Capture-Western
    hit Duina AA (1996)
    Two-hybrid
    hit Zhao R (2005)
    Affinity Capture-MS
    hit Zhao R (2005)
    bait Krogan NJ (2006)
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SBA1
  • YKL117W
    		•  The BioGRID Database Seperator Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity|Sba1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Fang Y (1998)
    bait Forafonov F (2008)
    Reconstituted Complex
    bait Fang Y (1998)
    hit Richter K (2004)
    bait Siligardi G (2004)
    Two-hybrid
    hit Millson SH (2005)
    Co-crystal Structure
    hit Ali MM (2006)
    Biochemical Activity
    bait Forafonov F (2008)
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CNS1
  • YBR155W
    		•  The BioGRID Database Seperator Cns1p|TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Hainzl O (2004)
    hit Tesic M (2003)
    Affinity Capture-Western
    bait/hit Tesic M (2003)
    bait/hit Marsh JA (1998)
    Two-hybrid
    hit Zhao R (2005)
    hit Millson SH (2005)
    Affinity Capture-MS
    hit Zhao R (2005)
    Dosage Rescue
    hit Nathan DF (1999)
    Synthetic Growth Defect
    hit Tesic M (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR7
  • YJR032W
    		•  The BioGRID Database Seperator Cpr7p|Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Mayr C (2000)
    Affinity Capture-Western
    hit Liu XD (1999)
    bait/hit Marsh JA (1998)
    hit Duina AA (1996)
    bait Abbas-Terki T (2001)
    Two-hybrid
    hit Zhao R (2005)
    Affinity Capture-MS
    hit Zhao R (2005)
    Synthetic Lethality
    hit Zhao R (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC37
  • SMO1
  • YDR168W
    		•  The BioGRID Database Seperator Cdc37p|Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Abbas-Terki T (2000)
    Affinity Capture-MS
    hit Zhao R (2005)
    bait Krogan NJ (2006)
    Two-hybrid
    hit Millson SH (2005)
    Reconstituted Complex
    hit Siligardi G (2004)
    Dosage Rescue
    hit Yang XX (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAH1
  • YCR060W
    		•  The BioGRID Database Seperator HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs|Tah1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Zhao R (2005)
    bait Millson SH (2008)
    Two-hybrid
    hit Zhao R (2005)
    hit Millson SH (2005)
    hit Boulon S (2008)
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Marsh JA (1998)
    Protein-peptide
    hit Mariño-Ramirez L (2002)
    Reconstituted Complex
    hit Wayne N (2007)
    Co-crystal Structure
    hit Prodromou C (1997)
    hit Meyer P (2003)
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGT1
  • YOR057W
    		•  The BioGRID Database Seperator Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex|Sgt1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lingelbach LB (2004)
    bait Bansal PK (2004)
    Affinity Capture-MS
    hit Zhao R (2005)
    Reconstituted Complex
    hit Catlett MG (2006)
    Dosage Rescue
    bait Bansal PK (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPT1
  • YGR123C
    		•  The BioGRID Database Seperator Ppt1p|Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    hit Zhao R (2005)
    hit Krogan NJ (2006)
    Two-hybrid
    hit Zhao R (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDJ1
  • HSP40
  • MAS5
  • YNL064C
    		•  The BioGRID Database Seperator Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family|Ydj1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Liu XD (1999)
    Two-hybrid
    hit Millson SH (2005)
    Co-purification
    hit Zhang L (1998)
    Synthetic Lethality
    hit Kimura Y (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE11
  • YLR362W
    		•  The BioGRID Database Seperator Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p|Ste11p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lee P (2004)
    bait Louvion JF (1998)
    Two-hybrid
    hit Millson SH (2005)
    Phenotypic Suppression
    bait Louvion JF (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HCH1
  • YNL281W
    		•  The BioGRID Database Seperator Hch1p|Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Panaretou B (2002)
    hit Millson SH (2004)
    Affinity Capture-MS
    hit Zhao R (2005)
    Dosage Rescue
    hit Nathan DF (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    Phenotypic Enhancement
    bait Bali M (2003)
    Synthetic Lethality
    hit Flom G (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAP1
  • CYP1
  • YLR256W
    		•  The BioGRID Database Seperator Hap1p|Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Lee HC (2003)
    bait Lee HC (2002)
    Two-hybrid
    hit Millson SH (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLT2
  • BYC2
  • MPK1
  • SLK2
  • YHR030C
    		•  The BioGRID Database Seperator Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway|Slt2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Zhao R (2005)
    hit Millson SH (2005)
    Affinity Capture-Western
    bait/hit Millson SH (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSE1
  • LPG3
  • MSI3
  • YPL106C
    		•  The BioGRID Database Seperator ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Liu XD (1999)
    Affinity Capture-MS
    hit Zhao R (2005)
    Two-hybrid
    hit Millson SH (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT10
  • YFL011W
    		•  The BioGRID Database Seperator Hxt10p|Putative hexose transporter, expressed at low levels and expression is repressed by glucose; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Zhao R (2005)
    Two-hybrid
    hit Millson SH (2005)
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BSD2
  • YBR290W
    		•  The BioGRID Database Seperator Bsd2p|Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Zhao R (2005)
    hit Millson SH (2005)
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BNI4
  • YNL233W
    		•  The BioGRID Database Seperator Bni4p|Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via