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BioGRID | Network Layout for IQG1 for Saccharomyces cerevisiae
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IQG1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: CYK1, YPL242C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 8 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with IQG1

IQG1 was identified with 23 protein interactions and 20 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 MLC1
  • YGL106W
    		•  The BioGRID Database Seperator Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Boyne JR (2000) [4]
    hit Luo J (2004) [6]
    bait Shannon KB (2000) [3]
    Co-localization
    bait Shannon KB (2000) [3]
    PCA
    hit Pathmanathan S (2008) [3]
    Dosage Rescue
    hit Boyne JR (2000) [4]
    hit Shannon KB (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC42
  • YLR229C
    		•  The BioGRID Database Seperator Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
    Gene Ontology: [View List]
    Two-hybrid
    bait Richman TJ (2000) [9]
    hit Osman MA (1998) [4]
    PCA
    hit Pathmanathan S (2008) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MYO1
  • YHR023W
    		•  The BioGRID Database Seperator Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Boyne JR (2000) [4]
    Dosage Rescue
    bait Ko N (2007) [11]
    bait Jendretzki A (2009) [9]
    Synthetic Rescue
    bait Ko N (2007) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BSP1
  • YPR171W
    		•  The BioGRID Database Seperator Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
    Gene Ontology: [View List]
    FRET
    hit Wright DJ (2008) [3]
    Dosage Rescue
    hit Wright DJ (2008) [3]
    Synthetic Growth Defect
    hit Wright DJ (2008) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNL152W
  • YNL152W
    		•  The BioGRID Database Seperator Putative protein of unknown function; cytoplasmically localized protein proposed to function in phospholipid binding; YBL107C is an essential gene
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sanchez-Diaz A (2008) [4]
    Affinity Capture-Western
    bait Sanchez-Diaz A (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Osman MA (1998) [4]
    Reconstituted Complex
    bait Shannon KB (1999) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CMD1
  • YBR109C
    		•  The BioGRID Database Seperator Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Shannon KB (1999) [3]
    PCA
    hit Pathmanathan S (2008) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD4
  • YJR092W
    		•  The BioGRID Database Seperator Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Osman MA (2002) [4]
    Two-hybrid
    hit Osman MA (2002) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEM1
  • YML064C
    		•  The BioGRID Database Seperator GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Shannon KB (1999) [3]
    Synthetic Growth Defect
    hit Corbett M (2006) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDH1
  • HCT1
  • YGL003C
    		•  The BioGRID Database Seperator Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ko N (2007) [11]
    Phenotypic Suppression
    bait Tully GH (2009) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYK3
  • YDL117W
    		•  The BioGRID Database Seperator SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis
    Gene Ontology: [View List]
    Dosage Rescue
    hit Korinek WS () [2]
    Synthetic Growth Defect
    bait Jendretzki A (2009) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AFR1
  • YDR085C
    		•  The BioGRID Database Seperator Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p
    Gene Ontology: [View List]
    Two-hybrid
    hit Osman MA (1998) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AKR1
  • YDR264C
    		•  The BioGRID Database Seperator Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats
    Gene Ontology: [View List]
    Two-hybrid
    hit Osman MA (1998) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN5
  • NAS5
  • YDL147W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLC2
  • YPR188C
    		•  The BioGRID Database Seperator Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Tully GH (2009) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLN2
  • YPL256C
    		•  The BioGRID Database Seperator G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
    Gene Ontology: [View List]
    Dosage Lethality
    bait Zou J (2009) [109]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC10
  • YCR002C
    		•  The BioGRID Database Seperator Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Iwase M (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLN1
  • YMR199W
    		•  The BioGRID Database Seperator G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
    Gene Ontology: [View List]
    Dosage Lethality
    bait Zou J (2009) [109]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBF2
  • YGR092W
    		•  The BioGRID Database Seperator Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Corbett M (2006) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC3
  • PSL1
  • YER008C
    		•  The BioGRID Database Seperator Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Osman MA (2002) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC15
  • LYT1
  • YAR019C
    		•  The BioGRID Database Seperator Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Corbett M (2006) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBF20
  • YPR111W
    		•  The BioGRID Database Seperator Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Corbett M (2006) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHS1
  • SEP7
  • YDL225W
    		•  The BioGRID Database Seperator One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Iwase M (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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