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BioGRID | Network Layout for GAL4 for Saccharomyces cerevisiae
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GAL4

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: GAL81, YPL248C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p|Gal4p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 6 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with GAL4

GAL4 was identified with 127 protein interactions and 17 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 GAL80
  • YML051W
    		•  The BioGRID Database Seperator Gal80p|Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Chang C (2001)
    hit Melcher K (1995)
    hit Sil AK (1999)
    hit Ansari AZ (2002)
    hit Lue NF (1987)
    hit Pilauri V (2005)
    Protein-peptide
    bait Hertveldt K (2003)
    Reconstituted Complex
    bait/hit Melcher K (2000)
    bait/hit Melcher K (2005)
    hit Han Y (2000)
    hit Platt A (1998)
    hit Wu Y (1996)
    hit Lue NF (1987)
    bait Yun SJ (1991)
    hit Jeong CJ (2001)
    Two-hybrid
    hit Chang C (2001)
    hit Sil AK (1999)
    hit Marsolier MC (1997)
    hit Laser H (2000)
    bait/hit Pilauri V (2005)
    Co-purification
    hit Parthun MR (1992)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL11
  • ABE1
  • MED15
  • RAR3
  • YOL051W
    		•  The BioGRID Database Seperator Gal11p|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Park JM (2000)
    bait Lee YC (1999)
    Far Western
    bait Lee YC (1999)
    Reconstituted Complex
    hit Jeong CJ (2001)
    hit Hidalgo P (2001)
    hit Parthun MR (1992)
    hit Lu Z (2005)
    bait Barberis A (1995)
    hit Lim MK (2007)
    Two-hybrid
    hit Gaudreau L (1997)
    bait/hit Lim MK (2007)
    Dosage Rescue
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT15
  • BTF1
  • TBP1
  • YER148W
    		•  The BioGRID Database Seperator Spt15p|TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Melcher K (1995)
    bait/hit Ansari AZ (2002)
    bait/hit Ansari AZ (1998)
    Reconstituted Complex
    hit Melcher K (1995)
    bait Ansari AZ (1998)
    hit Xie Y (2000)
    hit Ding WV (1997)
    hit Wu Y (1996)
    Two-hybrid
    bait Bongards C (2003)
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSN3
  • CDK8
  • GIG2
  • NUT7
  • YPL042C
    		•  The BioGRID Database Seperator Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression|Ssn3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Ansari AZ (2002)
    Two-hybrid
    hit Ansari AZ (2002)
    hit Traven A (2002)
    hit Lim MK (2007)
    Biochemical Activity
    bait Hirst M (1999)
    bait Ansari AZ (2005)
    Dosage Lethality
    bait Zaman Z (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT6
  • CIM3
  • CRL3
  • SCB68
  • YGL048C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle|Rpt6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Melcher K (1995)
    hit Jeong CJ (2001)
    Reconstituted Complex
    bait/hit Swaffield JC (1995)
    hit Gonzalez F (2002)
    Co-localization
    hit Gonzalez F (2002)
    Phenotypic Suppression
    hit Archer CT (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT4
  • CRL13
  • PCS1
  • SUG2
  • YOR259C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle|Rpt4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Chang C (2001)
    Two-hybrid
    hit Chang C (2001)
    Reconstituted Complex
    hit Gonzalez F (2002)
    Co-localization
    bait Gonzalez F (2002)
    Phenotypic Suppression
    hit Russell SJ (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB4
  • MED17
  • YER022W
    		•  The BioGRID Database Seperator Srb4p|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Koh SS (1998)
    hit Park JM (2000)
    bait Jeong CJ (2001)
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUA7
  • SOH4
  • YPR086W
    		•  The BioGRID Database Seperator Sua7p|Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Melcher K (1995)
    Reconstituted Complex
    hit Wu Y (1996)
    hit Zhang DY (2000)
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF10
  • TAF23
  • TAF25
  • YDR167W
    		•  The BioGRID Database Seperator Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification|Taf10p; protein coding
    Gene Ontology: [View List]
    Co-localization
    hit Larschan E (2001)
    hit Bhaumik SR (2001)
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF6
  • TAF60
  • YGL112C
    		•  The BioGRID Database Seperator Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4|Taf6p; protein coding
    Gene Ontology: [View List]
    Co-localization
    hit Larschan E (2001)
    hit Bhaumik SR (2001)
    Affinity Capture-Western
    hit Brown CE (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF12
  • TAF61
  • TAF68
  • YDR145W
    		•  The BioGRID Database Seperator Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A|Taf12p; protein coding
    Gene Ontology: [View List]
    Co-localization
    hit Larschan E (2001)
    hit Bhaumik SR (2001)
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO21
  • RPB1
  • RPB220
  • SUA8
  • YDL140C
    		•  The BioGRID Database Seperator RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime|Rpo21p; protein coding
    Gene Ontology: [View List]
    Co-localization
    hit Bhaumik SR (2001)
    Phenotypic Enhancement
    bait Allison LA (1989)
    Phenotypic Suppression
    hit Allison LA (1989)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT3
  • YDR392W
    		•  The BioGRID Database Seperator Spt3p|Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; protein coding
    Gene Ontology: [View List]
    Co-localization
    hit Bhaumik SR (2001)
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NHP6B
  • YBR090C-A
  • YBR089C-A
    		•  The BioGRID Database Seperator High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Ap; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters|Nhp6bp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Laser H (2000)
    Reconstituted Complex
    bait Laser H (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRA1
  • YHR099W
    		•  The BioGRID Database Seperator Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation|Tra1p; protein coding
    Gene Ontology: [View List]
    FRET
    hit Bhaumik SR (2004)
    Affinity Capture-Western
    hit Brown CE (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSN8
  • GIG3
  • NUT9
  • RYE2
  • YNL025C
    		•  The BioGRID Database Seperator Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance|Ssn8p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Traven A (2002)
    Biochemical Activity
    bait Ansari AZ (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB7
  • MED21
  • YDR308C
    		•  The BioGRID Database Seperator Srb7p|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Park JM (2000)
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADA2
  • SWI8
  • YDR448W
    		•  The BioGRID Database Seperator Ada2p|Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Melcher K (1995)
    Reconstituted Complex
    hit Carrozza MJ (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF13
  • FUN81
  • TAF19
  • YML098W
    		•  The BioGRID Database Seperator TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors|Taf13p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF1
  • CAT1
  • CCR1
  • GLC2
  • YDR477W
    		•  The BioGRID Database Seperator AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis|Snf1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Lo WS (2005)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHO1
  • YPL127C
    		•  The BioGRID Database Seperator Hho1p|Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF11
  • TAF40
  • YML015C
    		•  The BioGRID Database Seperator TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors|Taf11p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA1
  • H2A1
  • SPT11
  • YDR225W
    		•  The BioGRID Database Seperator Hta1p|One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF4
  • MPT1
  • TAF48
  • TSG2
  • YMR005W
    		•  The BioGRID Database Seperator TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate|Taf4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF7
  • TAF67
  • YMR227C
    		•  The BioGRID Database Seperator TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation|Taf7p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubi4p|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Archer CT (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCL1
  • YPR025C
    		•  The BioGRID Database Seperator Ccl1p|Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIR4
  • ASD1
  • STE9
  • UTH2
  • YDR227W
    		•  The BioGRID Database Seperator Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan|Sir4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Lim MK (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF2
  • GAM1
  • HAF1
  • SWI2
  • YOR290C
    		•  The BioGRID Database Seperator Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p|Snf2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid