The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for POP2 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

POP2

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: CAF1, YNR052C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 11 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with POP2

POP2 was identified with 107 protein interactions and 205 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 CCR4
  • FUN27
  • NUT21
  • YAL021C
    		•  The BioGRID Database Seperator Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2004) [890]
    bait/hit Gavin AC (2002) [3400]
    bait Ho Y (2002) [3666]
    bait Chen J (2001) [26]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    hit Norbeck J (2008) [2]
    Affinity Capture-Western
    hit Clark LB (2004) [3]
    hit Russell P (2002) [6]
    hit Liu HY (1998) [31]
    bait/hit Draper MP (1995) [4]
    hit Tucker M (2001) [5]
    hit Bai Y (1999) [21]
    Two-hybrid
    hit Clark LB (2004) [3]
    bait Liu HY (2001) [24]
    bait Liu HY (1998) [31]
    bait Liu HY (1997) [9]
    hit Hata H (1998) [18]
    bait Draper MP (1995) [4]
    bait Yu H (2008) [1778]
    Co-purification
    bait Tucker M (2001) [5]
    bait Liu HY (1997) [9]
    Co-fractionation
    bait Bai Y (1999) [21]
    Dosage Rescue
    hit Tucker M (2002) [1]
    hit Hata H (1998) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC39
  • ROS1
  • NOT1
  • SMD6
  • YCR093W
    		•  The BioGRID Database Seperator Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002) [3400]
    bait Chen J (2001) [26]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    hit Norbeck J (2008) [2]
    Affinity Capture-Western
    hit Clark LB (2004) [3]
    hit Russell P (2002) [6]
    hit Liu HY (1998) [31]
    bait Bai Y (1999) [21]
    Two-hybrid
    bait/hit Liu HY (1998) [31]
    Co-purification
    bait Liu HY (1998) [31]
    bait Takagi Y (2006) [24]
    PCA
    bait Tarassov K (2008) [2616]
    Synthetic Lethality
    hit Maillet L (2002) [21]
    hit Maillet L (2000) [22]
    Synthetic Rescue
    bait Maillet L (2002) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAF40
  • YNL288W
    		•  The BioGRID Database Seperator Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait/hit Chen J (2001) [26]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    bait Mulder KW (2007) [58]
    bait Azzouz N (2009) [8]
    Affinity Capture-Western
    hit Russell P (2002) [6]
    bait Lenssen E (2007) [12]
    PCA
    bait Tarassov K (2008) [2616]
    Two-hybrid
    bait Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC36
  • NOT2
  • DNA19
  • YDL165W
    		•  The BioGRID Database Seperator Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Russell P (2002) [6]
    hit Liu HY (1998) [31]
    bait Azzouz N (2009) [51]
    Two-hybrid
    bait/hit Liu HY (1998) [31]
    Synthetic Lethality
    hit Maillet L (2000) [22]
    bait Bai Y (1999) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT2
  • NOT4
  • SIG1
  • YER068W
    		•  The BioGRID Database Seperator Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Russell P (2002) [6]
    hit Liu HY (1998) [31]
    bait Azzouz N (2009) [51]
    PCA
    bait Tarassov K (2008) [2616]
    Synthetic Lethality
    hit Maillet L (2002) [21]
    hit Maillet L (2000) [22]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DHH1
  • YDL160C
    		•  The BioGRID Database Seperator Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Hata H (1998) [18]
    bait Coller JM (2001) [9]
    Two-hybrid
    hit Hata H (1998) [18]
    Dosage Rescue
    hit Hata H (1998) [18]
    hit Ohn T (2007) [6]
    Synthetic Lethality
    bait Maillet L (2002) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOT3
  • YIL038C
    		•  The BioGRID Database Seperator Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Liu HY (1998) [31]
    bait Bai Y (1999) [21]
    PCA
    bait Tarassov K (2008) [2616]
    Synthetic Growth Defect
    hit Maillet L (2002) [21]
    Synthetic Rescue
    bait Maillet L (2002) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAF130
  • YGR134W
    		•  The BioGRID Database Seperator Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Chen J (2001) [26]
    hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOT5
  • YPR072W
    		•  The BioGRID Database Seperator Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Russell P (2002) [6]
    bait Bai Y (1999) [21]
    Synthetic Lethality
    hit Maillet L (2002) [21]
    hit Maillet L (2000) [22]
    bait Bai Y (1999) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPT5
  • HTR1
  • UTH4
  • PUF5
  • YGL178W
    		•  The BioGRID Database Seperator Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Hook BA (2007) [4]
    PCA
    bait Tarassov K (2008) [2616]
    Dosage Rescue
    hit Hata H (1998) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAB1
  • YER165W
    		•  The BioGRID Database Seperator Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
    Gene Ontology: [View List]
    Biochemical Activity
    bait Simon E (2007) [5]
    Synthetic Lethality
    bait Ohn T (2007) [6]
    bait Simon E (2007) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOB1
  • YIL106W
    		•  The BioGRID Database Seperator Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Komarnitsky SI (1998) [10]
    Two-hybrid
    bait Komarnitsky SI (1998) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBF2
  • YGR092W
    		•  The BioGRID Database Seperator Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Liu HY (1997) [9]
    Two-hybrid
    hit Liu HY (1998) [31]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAK1
  • YJL141C
    		•  The BioGRID Database Seperator Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Moriya H (2001) [4]
    Biochemical Activity
    bait Moriya H (2001) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRI1
  • YIR008C
    		•  The BioGRID Database Seperator Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL1
  • HPR3
  • CDC17
  • CRT5
  • YNL102W
    		•  The BioGRID Database Seperator Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL12
  • YBL035C
    		•  The BioGRID Database Seperator B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRI2
  • YKL045W
    		•  The BioGRID Database Seperator Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSM1
  • YCR086W
    		•  The BioGRID Database Seperator Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD52
  • YML032C
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Schild D (1995) [6]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL30
  • YBR088C
    		•  The BioGRID Database Seperator Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Zhang Z (2000) [2]
    Phenotypic Enhancement
    bait Zhang Z (2000) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCP1
  • YOL149W
    		•  The BioGRID Database Seperator Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Coller JM (2001) [9]
    Synthetic Lethality
    bait Tucker M (2001) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFP1
  • VMA1
  • CLS8
  • YDL185W
    		•  The BioGRID Database Seperator Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIM1
  • YEB1
  • YER016W
    		•  The BioGRID Database Seperator Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2004) [323]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STM1
  • MPT4
  • YLR150W
    		•  The BioGRID Database Seperator Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
    Gene Ontology: [View List]
    Dosage Rescue
    hit Hata H (1998) [18]
    hit Ohn T (2007) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG2
  • END11
  • YMR202W
    		•  The BioGRID Database Seperator C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAR3
  • OSR11
  • YPR141C
    		•  The BioGRID Database Seperator Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     XRS2
  • YDR369C
    		•  The BioGRID Database Seperator Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Pan X (2006) [5331]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRC1
  • YCL060C
  • YCL061C
    		•  The BioGRID Database Seperator S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Traven A (2005) [6]
    Phenotypic Enhancement
    hit Traven A (2005) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUN1
  • YDL101C
    		•  The BioGRID Database Seperator Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Traven A (2005) [6]
    Synthetic Lethality
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD54
  • XRS1
  • YGL163C
    		•  The BioGRID Database Seperator DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT107
  • ESC4
  • YHR154W
    		•  The BioGRID Database Seperator Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRS4
  • YDR439W
    		•  The BioGRID Database Seperator Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT3
  • ROX7
  • YMR070W
    		•  The BioGRID Database Seperator Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOG1
  • YJR074W
    		•  The BioGRID Database Seperator Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT101
  • CUL8
  • YJL047C
    		•  The BioGRID Database Seperator Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASF1
  • CIA1
  • YJL115W
    		•  The BioGRID Database Seperator Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS1
  • SLM6
  • RTT108
  • YPR164W
    		•  The BioGRID Database Seperator Protein likely involved in protection against replication-dependent DNA damage; mutants are sensitive to methyl methanesulfonate (MMS); implicated in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD51
  • MUT5
  • YER095W
    		•  The BioGRID Database Seperator Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGS1
  • YMR190C
    		•  The BioGRID Database Seperator Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NST1
  • YNL091W
    		•  The BioGRID Database Seperator Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIL1
  • YGR086C
    		•  The BioGRID Database Seperator Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EGD2
  • YHR193C
    		•  The BioGRID Database Seperator Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSE1
  • YHL002W
    		•  The BioGRID Database Seperator Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PUF4
  • YGL023
  • YGL014W
    		•  The BioGRID Database Seperator Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Hook BA (2007) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TCP1
  • CCT1
  • YDR212W
    		•  The BioGRID Database Seperator Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT106
  • YNL206C
    		•  The BioGRID Database Seperator Protein with a role in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Huang S (2005) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIN2
  • YLR096W
    		•  The BioGRID Database Seperator Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSI1
  • YMR025W
    		•  The BioGRID Database Seperator Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POP1
  • YNL221C
    		•  The BioGRID Database Seperator Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Wolf DA (1999) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSN2
  • SRB9
  • NUT8
  • MED13
  • YDR443C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
    Gene Ontology: [View List]
    Two-hybrid
    hit Liu HY (2001) [24]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM16
  • YPR046W
    		•  The BioGRID Database Seperator Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA
    Gene Ontology: [View List]
    Two-hybrid
    bait Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EGD1
  • YPL037C
    		•  The BioGRID Database Seperator Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
    Gene Ontology: [View List]
    Two-hybrid
    bait Panasenko O (2006) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI3
  • YNL197C
    		•  The BioGRID Database Seperator RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTT1
  • SPS101
  • YGR088W
    		•  The BioGRID Database Seperator Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
    Gene Ontology: [View List]
    Two-hybrid
    bait Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DEF1
  • VID31
  • YKL054C
    		•  The BioGRID Database Seperator RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIM1
  • YCR028C-A
    		•  The BioGRID Database Seperator Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BTT1
  • YDR252W
    		•  The BioGRID Database Seperator Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex (alpha, beta1, beta3) which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Cui Y (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR374C
  • YDR374C
    		•  The BioGRID Database Seperator Putative protein of unknown function
    Gene Ontology: [View List]
    Two-hybrid
    bait Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOF2
  • YKR010C
    		•  The BioGRID Database Seperator Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     THP2
  • YHR167W
    		•  The BioGRID Database Seperator Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWR1
  • YDR334W
    		•  The BioGRID Database Seperator Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS33
  • CLS14
  • SLP1
  • VAM5
  • YLR396C
    		•  The BioGRID Database Seperator ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF1
  • VID21
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI6
  • PSL8
  • SDS11
  • YLR182W
    		•  The BioGRID Database Seperator Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS20
  • VPT20
  • CHM6
  • VPL10
  • YMR077C
    		•  The BioGRID Database Seperator Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS1
  • GRD1
  • LAM1
  • VPL1
  • YKR001C
    		•  The BioGRID Database Seperator Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID22
  • YLR373C
    		•  The BioGRID Database Seperator Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS24
  • DID3
  • YKL041W
    		•  The BioGRID Database Seperator One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS30
  • ATG6
  • VPT30
  • APG6
  • YPL120W
    		•  The BioGRID Database Seperator Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC14
  • YLR386W
    		•  The BioGRID Database Seperator Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS167
  • YDR388W
    		•  The BioGRID Database Seperator Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAP30
  • YMR263W
    		•  The BioGRID Database Seperator Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SDS3
  • YIL084C
    		•  The BioGRID Database Seperator Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIC1
  • SDB25
  • YLR079W
    		•  The BioGRID Database Seperator Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS52
  • SAC2
  • YDR484W
    		•  The BioGRID Database Seperator Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC1
  • RSD1
  • YKL212W
    		•  The BioGRID Database Seperator Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS161
  • FUS7
  • END6
  • SPE161
  • YCR009C
    		•  The BioGRID Database Seperator Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS36
  • GRD12
  • VAC3
  • VPL11
  • YLR417W
    		•  The BioGRID Database Seperator Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIN3
  • CPE1
  • SDI1
  • SDS16
  • YOL004W
    		•  The BioGRID Database Seperator Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF5
  • HAF4
  • SWI10
  • TYE4
  • YBR289W
    		•  The BioGRID Database Seperator Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SST2
  • YLR452C
    		•  The BioGRID Database Seperator GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STB5
  • YHR178W
    		•  The BioGRID Database Seperator Activator of multidrug resistance genes, forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a PDRE (pleotropic drug resistance element) in vitro; binds Sin3p in a two-hybrid assay
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STP22
  • VPS23
  • YCL008C
    		•  The BioGRID Database Seperator Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRO9
  • YCL037C
    		•  The BioGRID Database Seperator Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB2
  • HRS2
  • MED20
  • YHR041C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF8
  • VPS22
  • YPL002C
    		•  The BioGRID Database Seperator Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOH1
  • MED31
  • YGL127C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI4
  • ART1
  • YER111C
    		•  The BioGRID Database Seperator DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DED1
  • SPP81
  • YOR204W
    		•  The BioGRID Database Seperator ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Beckham C (2008) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLA4
  • ERC10
  • YNL298W
    		•  The BioGRID Database Seperator Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Traven A (2009) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELM1
  • LDB9
  • YKL048C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Traven A (2009) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIN4
  • ERC47
  • YDR507C
    		•  The BioGRID Database Seperator Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Traven A (2009) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHS1
  • SEP7
  • YDL225W
    		•  The BioGRID Database Seperator One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Traven A (2009) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWE1
  • WEE1
  • YJL187C
    		•  The BioGRID Database Seperator Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Traven A (2009) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EPL1
  • YFL024C
    		•  The BioGRID Database Seperator Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNG2
  • EAF4
  • NBN1
  • YHR090C
    		•  The BioGRID Database Seperator Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD7
  • YJR052W
    		•  The BioGRID Database Seperator Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Gaillard H (2009) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG8
  • AUT7
  • CVT5
  • APG8
  • YBL078C
    		•  The BioGRID Database Seperator Protein required for autophagy; modified by the serial action of Atg4p, Atg7p, and Atg3p, and conjugated at the C terminus with phosphatidylethanolamine, to become the form essential for generation of autophagosomes
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD31
  • CWC14
  • YCR063W
    		•  The BioGRID Database Seperator Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG3
  • SYR1
  • PSO6
  • YLR056W
    		•  The BioGRID Database Seperator C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS9
  • VPL31
  • VPT9
  • YML097C
    		•  The BioGRID Database Seperator A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO80
  • VAC5
  • AGS3
  • TUP7
  • YOL001W
    		•  The BioGRID Database Seperator Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRL3
  • YKR091W
    		•  The BioGRID Database Seperator Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEF4
  • EFC1
  • YKL081W
    		•  The BioGRID Database Seperator Translation elongation factor EF-1 gamma
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG9
  • AUT9
  • APG9
  • CVT7
  • YDL149W
    		•  The BioGRID Database Seperator Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUM1
  • PAC12
  • YDR150W
    		•  The BioGRID Database Seperator Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP1
  • ACT5
  • YHR129C
    		•  The BioGRID Database Seperator Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
    Gene Ontology: [View List]
    Synthetic Haploinsufficiency
    bait Haarer B (2007) [201]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Mitchell L (2008) [313]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRC19
  • YLL033W
    		•  The BioGRID Database Seperator Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52 foci
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNL086W
  • YNL086W
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATP23
  • YNR020C
    		•  The BioGRID Database Seperator Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YEL007W
  • YEL007W
    		•  The BioGRID Database Seperator Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR065W
  • YDR065W
    		•  The BioGRID Database Seperator Protein of unknown function, required for vacuolar acidification; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS45
  • VPL28
  • STT10
  • YGL095C
    		•  The BioGRID Database Seperator Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS53
  • YJL029C
    		•  The BioGRID Database Seperator Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAF9
  • YNL107W
    		•  The BioGRID Database Seperator Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LDB19
  • YOR322C
    		•  The BioGRID Database Seperator Protein of unknown function involved in maintenance of proper telomere length; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD27
  • ERC11
  • FEN1
  • RTH1
  • YKL113C
    		•  The BioGRID Database Seperator 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC33
  • TIF45
  • YOL139C
    		•  The BioGRID Database Seperator Cytoplasmic mRNA cap binding protein; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p)
    Gene Ontology: [View List]
    Dosage Rescue
    bait Ohn T (2007) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT3
  • YDR392W
    		•  The BioGRID Database Seperator Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Badarinarayana V (2000) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT8
  • YLR055C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Badarinarayana V (2000) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX8
  • YER116C
    		•  The BioGRID Database Seperator Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAE2
  • COM1
  • YGL175C
    		•  The BioGRID Database Seperator Protein with a role in accurate meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD53
  • MEC2
  • SPK1
  • LSD1
  • YPL153C
    		•  The BioGRID Database Seperator Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GET2
  • RMD7
  • HUR2
  • YER083C
    		•  The BioGRID Database Seperator Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS4
  • END13
  • GRD13
  • VPT10
  • YPR173C
    		•  The BioGRID Database Seperator AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM30
  • DSG1
  • YLR368W
    		•  The BioGRID Database Seperator F-box protein; physically associates with mitochondria and is required for normal mitochondrial fusion in rich medium, during sporulation, and in mating cells; promotes ubiquitin-mediated degradation of Gal4p in some strains
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARF1
  • YDL192W
    		•  The BioGRID Database Seperator ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP6
  • YLR085C
    		•  The BioGRID Database Seperator Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP8
  • YOR141C
    		•  The BioGRID Database Seperator Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC5
  • AOR1
  • YBR231C
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAT1
  • AAA1
  • YDL040C
    		•  The BioGRID Database Seperator Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS22
  • SLM2
  • YLR320W
    		•  The BioGRID Database Seperator Protein involved in resistance to ionizing radiation; acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRE11
  • XRS4
  • NGS1
  • RAD58
  • YMR224C
    		•  The BioGRID Database Seperator Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MUS81
  • SLX3
  • YDR386W
    		•  The BioGRID Database Seperator Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATP1
  • YBL099W
    		•  The BioGRID Database Seperator Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATP10
  • YLR393W
    		•  The BioGRID Database Seperator Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATP7
  • YKL016C
    		•  The BioGRID Database Seperator Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIK1
  • ARM5
  • PAC14
  • YCL029C
    		•  The BioGRID Database Seperator Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRO1
  • ASI6
  • NPI3
  • LPF2
  • YPL084W
    		•  The BioGRID Database Seperator Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATP5
  • OSC1
  • YDR298C
    		•  The BioGRID Database Seperator Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATP4
  • LPF7
  • YPL078C
    		•  The BioGRID Database Seperator Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATP11
  • YNL315C
    		•  The BioGRID Database Seperator Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATP17
  • YDR377W
    		•  The BioGRID Database Seperator Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GET1
  • MDM39
  • YGL020C
    		•  The BioGRID Database Seperator Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRS2
  • HPR5
  • YJL092W
    		•  The BioGRID Database Seperator DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT6
  • SSN20
  • CRE2
  • YGR116W
    		•  The BioGRID Database Seperator Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Draper MP (1995) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIN8
  • SDS15
  • KSL2
  • YEL061C
    		•  The BioGRID Database Seperator Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2004) [323]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARD1
  • YHR013C
    		•  The BioGRID Database Seperator Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB4
  • MED17
  • YER022W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Lee TI (1998) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF1
  • TAF130
  • TAF145
  • YGR274C
    		•  The BioGRID Database Seperator TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Deluen C (2002) [22]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB2
  • YPR119W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
    Gene Ontology: [View List]
    Dosage Lethality
    hit Liu HY (1997) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PKC1
  • HPO2
  • STT1
  • CLY15
  • YBL105C
    		•  The BioGRID Database Seperator Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
    Gene Ontology: [View List]
    Dosage Rescue
    hit Hata H (1998) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE1
  • YDL074C
    		•  The BioGRID Database Seperator E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF18
  • CHL12
  • YMR078C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX5
  • HEX3
  • YDL013W
    		•  The BioGRID Database Seperator Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HIR1
  • YBL008W
    		•  The BioGRID Database Seperator Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HIR2
  • SPT1
  • YOR038C
    		•  The BioGRID Database Seperator Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3, and H4 genes; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIA2
  • YOR29-31
  • YOR080W
    		•  The BioGRID Database Seperator Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCC1
  • YCL016C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator