The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for LST8 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

LST8

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YNL006W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Lst8p|Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 15 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with LST8

LST8 was identified with 30 protein interactions and 15 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 TOR2
  • DRR2
  • YKL203C
    		•  The BioGRID Database Seperator PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis|Tor2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Chen EJ (2003)
    bait/hit Wedaman KP (2003)
    hit Loewith R (2002)
    bait Wullschleger S (2005)
    Affinity Capture-MS
    bait/hit Reinke A (2004)
    Co-purification
    bait Wedaman KP (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOR1
  • DRR1
  • YJR066W
    		•  The BioGRID Database Seperator PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis|Tor1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Chen EJ (2003)
    hit Wedaman KP (2003)
    bait/hit Loewith R (2002)
    Affinity Capture-MS
    bait/hit Reinke A (2004)
    Co-purification
    bait Wanke V (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TSC11
  • AVO3
  • YER093C
    		•  The BioGRID Database Seperator Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain|Tsc11p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Loewith R (2002)
    bait Wullschleger S (2005)
    Affinity Capture-MS
    hit Reinke A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AVO1
  • YOL078W
    		•  The BioGRID Database Seperator Avo1p|Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Loewith R (2002)
    hit Wullschleger S (2005)
    Affinity Capture-MS
    hit Reinke A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KOG1
  • LAS24
  • YHR186C
    		•  The BioGRID Database Seperator Kog1p|Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Loewith R (2002)
    Affinity Capture-MS
    bait/hit Reinke A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AVO2
  • YMR068W
    		•  The BioGRID Database Seperator Avo2p|Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Loewith R (2002)
    Affinity Capture-MS
    hit Reinke A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC13
  • ANU3
  • YLR208W
    		•  The BioGRID Database Seperator Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles|Sec13p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Roberg KJ (1999)
    bait Roberg KJ (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP1
  • VPS10
  • VPT1
  • YBL017C
    		•  The BioGRID Database Seperator Pep1p|Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENO2
  • YHR174W
    		•  The BioGRID Database Seperator Eno2p|Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC61
  • YLR378C
    		•  The BioGRID Database Seperator Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER|Sec61p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TCO89
  • YPL180W
    		•  The BioGRID Database Seperator Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin|Tco89p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Reinke A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO8
  • YDR481C
    		•  The BioGRID Database Seperator Pho8p|Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIT61
  • YJL058C
    		•  The BioGRID Database Seperator Bit61p|Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Reinke A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PGK1
  • YCR012W
    		•  The BioGRID Database Seperator 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis|Pgk1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKU80
  • HDF2
  • YMR106C
    		•  The BioGRID Database Seperator Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair|Yku80p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YFR039C
  • YFR039C
    		•  The BioGRID Database Seperator Putative protein of unknown function; YFR039C is not an essential gene|Yfr039cp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMR1
  • BSD1
  • LDB1
  • SSC1
  • YGL167C
    		•  The BioGRID Database Seperator High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease|Pmr1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Devasahayam G (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM39
  • ALG12
  • YNR030W
    		•  The BioGRID Database Seperator Alg12p|Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CWH41
  • GLS1
  • DER7
  • YGL027C
    		•  The BioGRID Database Seperator Cwh41p|Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Chen EJ (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TCP1
  • CCT1
  • YDR212W
    		•  The BioGRID Database Seperator Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide|Tcp1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Kabir MA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPD2
  • YOL088C
    		•  The BioGRID Database Seperator Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p|Mpd2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFB2
  • YNL049C
    		•  The BioGRID Database Seperator Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy|Sfb2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCT6
  • HTR3
  • TCP20
  • TCP6
  • YDR188W
    		•  The BioGRID Database Seperator Cct6p|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Kabir MA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GDH1
  • URE1
  • YOR375C
    		•  The BioGRID Database Seperator Gdh1p|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Chen EJ (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FKS1
  • CND1
  • CWH53
  • ETG1
  • YLR342W
    		•  The BioGRID Database Seperator Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling|Fks1p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Chen EJ (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLN3
  • YER040W
    		•  The BioGRID Database Seperator Gln3p|Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Chen EJ (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTG2
  • YGL252C
    		•  The BioGRID Database Seperator Rtg2p|Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Liu Z (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCT4
  • TCP4
  • ANC2
  • YDL143W
    		•  The BioGRID Database Seperator Cct4p|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Kabir MA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCT8
  • YJL008C
    		•  The BioGRID Database Seperator Cct8p|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Kabir MA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.