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BioGRID | Network Layout for POL2 for Saccharomyces cerevisiae
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POL2

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: DUN2, YNL262W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Catalytic subunit of DNA polymerase (II) epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 15 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with POL2

POL2 was identified with 82 protein interactions and 45 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 DPB2
  • YPR175W
    		•  The BioGRID Database Seperator Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait/hit Tackett AJ (2005) [25]
    hit Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Ohya T (2002) [6]
    hit Kesti T (2004) [3]
    hit Tsubota T (2006) [4]
    Two-hybrid
    bait/hit Edwards S (2003) [22]
    bait/hit Dua R (2000) [15]
    bait/hit Dua R (1998) [4]
    bait Jaszczur M (2008) [3]
    hit Lou H (2008) [10]
    bait Jaszczur M (2009) [1]
    Reconstituted Complex
    bait Dua R (2000) [15]
    Co-purification
    hit Pavlov YI (2004) [6]
    hit Dua R (2002) [3]
    hit Tsubota T (2006) [4]
    Co-fractionation
    hit Chilkova O (2003) [3]
    Co-crystal Structure
    hit Asturias FJ (2006) [1]
    Dosage Rescue
    hit Dua R (2000) [15]
    Synthetic Lethality
    hit Kesti T (2004) [3]
    Phenotypic Enhancement
    bait Jaszczur M (2008) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPB4
  • YDR121W
    		•  The BioGRID Database Seperator Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Iida T (2004) [19]
    hit Ohya T (2002) [6]
    bait McConnell AD (2004) [4]
    Two-hybrid
    hit Dua R (2000) [15]
    Affinity Capture-MS
    bait Tackett AJ (2005) [25]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Co-purification
    bait Dua R (2000) [15]
    hit Pavlov YI (2004) [6]
    hit Dua R (2002) [3]
    hit Tsubota T (2006) [4]
    Co-fractionation
    hit Chilkova O (2003) [3]
    Dosage Rescue
    hit Iida T (2004) [19]
    Synthetic Lethality
    bait Ohya T (2000) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPB3
  • YBR278W
    		•  The BioGRID Database Seperator Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Tackett AJ (2005) [25]
    bait Krogan NJ (2006) [7079]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Ohya T (2002) [6]
    Two-hybrid
    hit Dua R (2000) [15]
    hit Dua R (1998) [4]
    Co-purification
    hit Dua R (2000) [15]
    hit Pavlov YI (2004) [6]
    hit Dua R (2002) [3]
    hit Tsubota T (2006) [4]
    Co-fractionation
    hit Chilkova O (2003) [3]
    Dosage Rescue
    hit Iida T (2004) [19]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPB11
  • YJL090C
    		•  The BioGRID Database Seperator Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Masumoto H (2000) [1]
    Two-hybrid
    hit Edwards S (2003) [22]
    Dosage Rescue
    hit Araki H (1995) [4]
    hit Kamimura Y (1998) [11]
    Synthetic Lethality
    bait Araki H (1995) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRC1
  • YCL060C
  • YCL061C
    		•  The BioGRID Database Seperator S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Lou H (2008) [10]
    Affinity Capture-Western
    bait/hit Lou H (2008) [10]
    Synthetic Lethality
    bait Lou H (2008) [10]
    Dosage Rescue
    hit Lou H (2008) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRF5
  • YNL299W
    		•  The BioGRID Database Seperator Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Edwards S (2003) [22]
    Two-hybrid
    bait/hit Edwards S (2003) [22]
    Synthetic Growth Defect
    hit Edwards S (2003) [22]
    Synthetic Lethality
    hit Edwards S (2003) [22]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAP2
  • TRF4
  • YOL115W
    		•  The BioGRID Database Seperator Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Edwards S (2003) [22]
    Two-hybrid
    hit Edwards S (2003) [22]
    Dosage Rescue
    bait Edwards S (2003) [22]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMC1
  • CHL10
  • YFL008W
    		•  The BioGRID Database Seperator Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
    Gene Ontology: [View List]
    Two-hybrid
    hit Edwards S (2003) [22]
    Synthetic Growth Defect
    hit Edwards S (2003) [22]
    Synthetic Lethality
    hit Edwards S (2003) [22]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM2
  • YBL023C
    		•  The BioGRID Database Seperator Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    Affinity Capture-Western
    bait Lou H (2008) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF4631
  • YGR162W
    		•  The BioGRID Database Seperator Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF18
  • CHL12
  • YMR078C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC33
  • TIF45
  • YOL139C
    		•  The BioGRID Database Seperator Cytoplasmic mRNA cap binding protein; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p)
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRI1
  • YIR008C
    		•  The BioGRID Database Seperator Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Brooke RG (1991) [3]
    Co-purification
    bait Plevani P (1985) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL1
  • HPR3
  • CDC17
  • CRT5
  • YNL102W
    		•  The BioGRID Database Seperator Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Brooke RG (1991) [3]
    Phenotypic Enhancement
    bait Pavlov YI (2004) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNR4
  • CRT3
  • PSO3
  • YGR180C
    		•  The BioGRID Database Seperator Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Lis ET (2008) [7]
    Phenotypic Enhancement
    hit Lis ET (2008) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EXO1
  • DHS1
  • YOR033C
    		•  The BioGRID Database Seperator 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Tran HT (1999) [4]
    hit Kirchner JM (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSH2
  • PMS5
  • YOL090W
    		•  The BioGRID Database Seperator Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Tran HT (1999) [4]
    bait Kirchner JM (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL3
  • HPR6
  • CDC2
  • TEX1
  • YDL102W
    		•  The BioGRID Database Seperator Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Morrison A (1994) [1]
    Phenotypic Enhancement
    hit Pavlov YI (2004) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRE11
  • XRS4
  • NGS1
  • RAD58
  • YMR224C
    		•  The BioGRID Database Seperator Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Tittel-Elmer M (2009) [6]
    Phenotypic Enhancement
    bait Tittel-Elmer M (2009) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD27
  • ERC11
  • FEN1
  • RTH1
  • YKL113C
    		•  The BioGRID Database Seperator 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Kirchner JM (2000) [3]
    bait Gary R (1999) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LHP1
  • LAH1
  • YLA1
  • YDL051W
    		•  The BioGRID Database Seperator RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLC7
  • CID1
  • DIS2
  • YER133W
    		•  The BioGRID Database Seperator Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gong Y (2009) [1420]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRM3
  • RTT104
  • YHR031C
    		•  The BioGRID Database Seperator DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Azvolinsky A (2006) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKA1
  • YIL035C
    		•  The BioGRID Database Seperator Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAR1
  • YHR089C
    		•  The BioGRID Database Seperator Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTB2
  • YBL002W
    		•  The BioGRID Database Seperator One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA2
  • H2A2
  • YBL003C
    		•  The BioGRID Database Seperator One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PUB1
  • RNP1
  • YNL016W
    		•  The BioGRID Database Seperator Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT5
  • YML010W
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lindstrom DL (2003) [113]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL2
  • DUN2
  • YNL262W
    		•  The BioGRID Database Seperator Catalytic subunit of DNA polymerase (II) epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair
    Gene Ontology: [View List]
    Two-hybrid
    hit Dua R (1998) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TDH2
  • GLD2
  • YJR009C
    		•  The BioGRID Database Seperator Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STM1
  • MPT4
  • YLR150W
    		•  The BioGRID Database Seperator Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CBF5
  • YLR175W
    		•  The BioGRID Database Seperator Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INM1
  • YHR046C
    		•  The BioGRID Database Seperator Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRI2
  • YKL045W
    		•  The BioGRID Database Seperator Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Brooke RG (1991) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC14
  • OAF3
  • YFR028C
    		•  The BioGRID Database Seperator Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Bloom J (2007) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS2
  • YGL087C
    		•  The BioGRID Database Seperator Protein involved in error-free postreplication DNA repair; forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Hanna M (2007) [39]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL4
  • YCR014C
    		•  The BioGRID Database Seperator DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Tseng SF (2008) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSA1
  • YOR29-17
  • YOR066W
    		•  The BioGRID Database Seperator Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Dosage Rescue
    hit Li JM (2008) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD24
  • YER173W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Frei C (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL30
  • YBR088C
    		•  The BioGRID Database Seperator Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Northam MR (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNL4
  • LIG4
  • YOR005C
    		•  The BioGRID Database Seperator DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Tseng SF (2008) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFC2
  • YJR068W
    		•  The BioGRID Database Seperator Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Noskov VN (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM10
  • DNA43
  • YIL150C
    		•  The BioGRID Database Seperator Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Kawasaki Y (2000) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSH6
  • PMS3
  • YDR097C
    		•  The BioGRID Database Seperator Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Tran HT (1999) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLD2
  • DRC1
  • YKL108W
    		•  The BioGRID Database Seperator Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Dosage Rescue
    hit Kamimura Y (1998) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFA1
  • BUF2
  • FUN3
  • RPA1
  • YAR007C
    		•  The BioGRID Database Seperator Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Santocanale C (1995) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSM3
  • YBR272C
    		•  The BioGRID Database Seperator Protein of unknown function, involved in DNA mismatch repair during slow growth; has weak similarity to Msh1p
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Fedorova IV (2004) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REV3
  • PSO1
  • YPL167C
    		•  The BioGRID Database Seperator Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Northam MR (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMS1
  • YNL082W
    		•  The BioGRID Database Seperator ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Erdeniz N (2005) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIZ1
  • ULL1
  • YDR409W
    		•  The BioGRID Database Seperator SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Northam MR (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.