| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
|
| VPS4 |
END13GRD13VPT10YPR173C |
|
AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism
|
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| DID2 |
VPS46FTI1CHM1YKR035W-A |
|
Class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors
|
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|
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| VTA1 |
YLR181C |
|
Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligimeriztion; binds to Vps4p, Vps20p, and Vps60p; may act at a late step in MVB formation
|
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| NAB2 |
YGL122C |
|
Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
|
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| APL3 |
YBL037W |
|
Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
|
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| VPS27 |
GRD11VPL23VPT27YNR006W |
|
Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
|
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|
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|
| SNF7 |
VPS32DID1RNS4YLR025W |
|
One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
|
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|
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|
| GCD1 |
TRA3YOR260W |
|
Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
|
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|
| IST1 |
YNL265C |
|
Putative translation initiation factor, as suggested by computational analysis of large-scale protein-protein interaction data
|
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| COG8 |
DOR1YML071C |
|
Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
|
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|
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|
| GCD7 |
YLR291C |
|
Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
|
|
|
|
|
| GCD6 |
YDR211W |
|
Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
|
|
|
|
|
| GCD2 |
GCD12YGR083C |
|
Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
|
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|
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|
| XKS1 |
YGR194C |
|
Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
|
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| GCN3 |
AAS2YKR026C |
|
Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
|
|
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|
|
| SUI3 |
YPL237W |
|
Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
|
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| PRO1 |
YDR300C |
|
Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis
|
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| RRP46 |
YGR095C |
|
Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
|
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| RRP40 |
YOL142W |
|
Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
|
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|
| DID4 |
VPT14VPS2REN1YKL002W |
|
Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
|
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| VPS60 |
CHM5MOS10YDR486C |
|
Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradation
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