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BioGRID | Network Layout for RPD3 for Saccharomyces cerevisiae
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RPD3

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: SDI2, MOF6, REC3, SDS6, YNL330C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Histone deacetylase; regulates transcription and silencing
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 30 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RPD3

RPD3 was identified with 152 protein interactions and 531 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 SIN3
  • CPE1
  • SDI1
  • SDS16
  • YOL004W
    		•  The BioGRID Database Seperator Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Colina AR (2005) [4]
    bait/hit Keogh MC (2005) [63]
    hit Carrozza MJ (2005) [47]
    bait/hit Carrozza MJ (2005) [45]
    hit Collins SR (2007) [9064]
    hit Sardiu ME (2009) [10]
    Affinity Capture-Western
    hit Lamb TM (2001) [2]
    bait Kadosh D (1997) [3]
    bait Kadosh D (1998) [1]
    bait Kasten MM (1997) [1]
    bait Schroeder M (2004) [3]
    hit Florens L (2006) [13]
    Co-purification
    bait Lechner T (2000) [4]
    Positive Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAP30
  • YMR263W
    		•  The BioGRID Database Seperator Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Colina AR (2005) [4]
    bait/hit Keogh MC (2005) [63]
    hit Carrozza MJ (2005) [47]
    hit Carrozza MJ (2005) [45]
    bait Collins SR (2007) [9064]
    hit Sardiu ME (2009) [10]
    hit Florens L (2006) [13]
    Affinity Capture-Western
    bait/hit Rundlett SE (1998) [2]
    bait/hit Zhang Y (1998) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UME1
  • WTM3
  • YPL139C
    		•  The BioGRID Database Seperator Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Ho Y (2002) [3666]
    hit Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Keogh MC (2005) [63]
    hit Carrozza MJ (2005) [47]
    hit Carrozza MJ (2005) [45]
    hit Collins SR (2007) [9064]
    hit Sardiu ME (2009) [10]
    Affinity Capture-Western
    hit Mallory MJ (2003) [1]
    bait/hit Kurdistani SK (2002) [2]
    hit Florens L (2006) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO23
  • YNL097C
    		•  The BioGRID Database Seperator Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Colina AR (2005) [4]
    bait/hit Keogh MC (2005) [63]
    hit Carrozza MJ (2005) [47]
    hit Carrozza MJ (2005) [45]
    bait Collins SR (2007) [9064]
    hit Sardiu ME (2009) [10]
    Affinity Capture-Western
    hit Loewith R (2001) [2]
    bait Nourani A (2003) [15]
    hit Florens L (2006) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SDS3
  • YIL084C
    		•  The BioGRID Database Seperator Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Colina AR (2005) [4]
    hit Keogh MC (2005) [63]
    hit Carrozza MJ (2005) [47]
    hit Carrozza MJ (2005) [45]
    bait Collins SR (2007) [9064]
    hit Sardiu ME (2009) [10]
    Affinity Capture-Western
    hit Lechner T (2000) [4]
    hit Florens L (2006) [13]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RXT2
  • RAF60
  • YBR095C
    		•  The BioGRID Database Seperator Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Keogh MC (2005) [63]
    hit Carrozza MJ (2005) [47]
    bait/hit Carrozza MJ (2005) [45]
    bait Collins SR (2007) [9064]
    hit Sardiu ME (2009) [10]
    Affinity Capture-Western
    hit Florens L (2006) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTI6
  • RXT1
  • YPL181W
    		•  The BioGRID Database Seperator Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    bait Keogh MC (2005) [63]
    hit Carrozza MJ (2005) [47]
    hit Carrozza MJ (2005) [45]
    hit Collins SR (2007) [9064]
    hit Sardiu ME (2009) [10]
    hit Florens L (2006) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DEP1
  • FUN54
  • YAL013W
    		•  The BioGRID Database Seperator Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    hit Keogh MC (2005) [63]
    bait/hit Carrozza MJ (2005) [47]
    hit Carrozza MJ (2005) [45]
    bait Collins SR (2007) [9064]
    hit Sardiu ME (2009) [10]
    Affinity Capture-Western
    hit Florens L (2006) [13]
    Positive Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF3
  • YPR023C
    		•  The BioGRID Database Seperator Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    bait/hit Keogh MC (2005) [63]
    bait/hit Carrozza MJ (2005) [45]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Florens L (2006) [13]
    Positive Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RCO1
  • YMR075W
    		•  The BioGRID Database Seperator Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    bait/hit Keogh MC (2005) [63]
    bait/hit Carrozza MJ (2005) [45]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Florens L (2006) [13]
    Positive Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RXT3
  • YDL076C
    		•  The BioGRID Database Seperator Subunit of the RPD3L complex; involved in histone deacetylation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Gavin AC (2006) [7592]
    hit Carrozza MJ (2005) [47]
    hit Carrozza MJ (2005) [45]
    bait Collins SR (2007) [9064]
    hit Sardiu ME (2009) [10]
    hit Florens L (2006) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UME6
  • NIM2
  • CAR80
  • RIM16
  • YDR207C
    		•  The BioGRID Database Seperator Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Lamb TM (2001) [2]
    Affinity Capture-MS
    bait/hit Carrozza MJ (2005) [47]
    hit Carrozza MJ (2005) [45]
    hit Florens L (2006) [13]
    Positive Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASH1
  • YKL185W
    		•  The BioGRID Database Seperator Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Carrozza MJ (2005) [47]
    hit Carrozza MJ (2005) [45]
    hit Sardiu ME (2009) [10]
    hit Florens L (2006) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN5
  • SWI9
  • ADA4
  • YGR252W
    		•  The BioGRID Database Seperator Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Sun ZW (1999) [7]
    bait Perez-Martin J (1998) [4]
    hit Lin YY (2008) [2599]
    Phenotypic Enhancement
    bait Burgess SM (1999) [1]
    Synthetic Lethality
    bait/hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LTE1
  • MSI2
  • YAL024C
    		•  The BioGRID Database Seperator Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Ye P (2005) [294]
    hit Lin YY (2008) [2599]
    hit Hwang WW (2009) [9]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT1
  • SIN2
  • BUR5
  • YBR010W
    		•  The BioGRID Database Seperator One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Sabet N (2003) [3]
    hit Ehrentraut S (2010) [13]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    bait Chang CS (2009) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC3
  • SWC1
  • YAL011W
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC5
  • AOR1
  • YBR231C
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS71
  • SWC6
  • YML041C
    		•  The BioGRID Database Seperator Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP6
  • YLR085C
    		•  The BioGRID Database Seperator Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS72
  • SWC2
  • YDR485C
    		•  The BioGRID Database Seperator Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIR2
  • MAR1
  • YDL042C
    		•  The BioGRID Database Seperator Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Sun ZW (1999) [7]
    bait Smith JS (1999) [4]
    hit Ehrentraut S (2010) [13]
    Phenotypic Suppression
    hit Zhou J (2009) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LGE1
  • YPL055C
    		•  The BioGRID Database Seperator Protein of unknown function; null mutant forms abnormally large cells
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Lethality
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOS2
  • RTL1
  • YGL194C
    		•  The BioGRID Database Seperator Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Wang A (2002) [1]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Cohen TJ (2008) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESS1
  • PIN1
  • PTF1
  • YJR017C
    		•  The BioGRID Database Seperator Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Arevalo-Rodriguez M (2000) [15]
    Synthetic Rescue
    bait Arevalo-Rodriguez M (2000) [15]
    Dosage Rescue
    bait Arevalo-Rodriguez M (2000) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR7
  • YJR032W
    		•  The BioGRID Database Seperator Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
    Gene Ontology: [View List]
    Two-hybrid
    hit Duina AA (1996) [4]
    Reconstituted Complex
    bait Duina AA (1996) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPD3
  • SDI2
  • MOF6
  • REC3
  • YNL330C
    		•  The BioGRID Database Seperator Histone deacetylase; regulates transcription and silencing
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Keogh MC (2005) [63]
    hit Carrozza MJ (2005) [47]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUP1
  • CRT4
  • UMR7
  • FLK1
  • YCR084C
    		•  The BioGRID Database Seperator General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Davie JK (2003) [6]
    bait Watson AD (2000) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOP1
  • MAK17
  • MAK1
  • YOL006C
    		•  The BioGRID Database Seperator Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKA1
  • YIL035C
    		•  The BioGRID Database Seperator Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR6
  • CYP40
  • YLR216C
    		•  The BioGRID Database Seperator Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
    Gene Ontology: [View List]
    Two-hybrid
    hit Duina AA (1996) [4]
    Reconstituted Complex
    bait Duina AA (1996) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD6
  • UBC2
  • PSO8
  • YGL058W
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Sun ZW (1999) [7]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIM1
  • YEB1
  • YER016W
    		•  The BioGRID Database Seperator Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2004) [323]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    hit Lin YY (2008) [2599]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI5
  • YDR146C
    		•  The BioGRID Database Seperator Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Nasmyth K (1987) [2]
    bait Stillman DJ (1994) [12]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI4
  • ART1
  • YER111C
    		•  The BioGRID Database Seperator DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Lethality
    bait Stillman DJ (1994) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAS4
  • YDR181C
    		•  The BioGRID Database Seperator Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Lethality
    bait Ehrentraut S (2010) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAS2
  • YMR127C
    		•  The BioGRID Database Seperator Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Lethality
    bait Ehrentraut S (2010) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSC1
  • YML128C
    		•  The BioGRID Database Seperator Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Lethality
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSF1
  • YLR087C
    		•  The BioGRID Database Seperator Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWR1
  • YDR334W
    		•  The BioGRID Database Seperator Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Lethality
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAS5
  • YOR213C
    		•  The BioGRID Database Seperator Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Lethality
    bait Ehrentraut S (2010) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression
    Gene Ontology: [View List]
    Synthetic Rescue
    bait/hit Lin YY (2008) [2599]
    bait Chang CS (2009) [17]
    Phenotypic Suppression
    bait Chang CS (2009) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GET1
  • MDM39
  • YGL020C
    		•  The BioGRID Database Seperator Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GET2
  • RMD7
  • HUR2
  • YER083C
    		•  The BioGRID Database Seperator Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Synthetic Lethality
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • SUN1
  • MCB1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HDA1
  • YNL021W
    		•  The BioGRID Database Seperator Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Tachibana C (2007) [6]
    Synthetic Growth Defect
    bait/hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT3
  • YDR392W
    		•  The BioGRID Database Seperator Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Ingvarsdottir K (2005) [143]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE1
  • YDL074C
    		•  The BioGRID Database Seperator E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POB3
  • YML069W
    		•  The BioGRID Database Seperator Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Formosa T (2001) [12]
    Synthetic Lethality
    bait VanDemark AP (2006) [9]
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Lottersberger F (2007) [12]
    Synthetic Rescue
    bait Lottersberger F (2007) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYC8
  • CRT8
  • SSN6
  • YBR112C
    		•  The BioGRID Database Seperator General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Davie JK (2003) [6]
    Synthetic Lethality
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SET3
  • YKR029C
    		•  The BioGRID Database Seperator Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC73
  • YLR418C
    		•  The BioGRID Database Seperator Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF1
  • YBR009C
    		•  The BioGRID Database Seperator One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
    Gene Ontology: [View List]
    Positive Genetic
    hit Collins SR (2007) [14430]
    Synthetic Rescue
    hit Ehrentraut S (2010) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC3
  • LEP1
  • YDR159W
    		•  The BioGRID Database Seperator Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS8
  • VPT8
  • FUN15
  • YAL002W
    		•  The BioGRID Database Seperator Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HDA3
  • PLO1
  • YPR179C
    		•  The BioGRID Database Seperator Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIM13
  • YGR181W
    		•  The BioGRID Database Seperator Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF7
  • YNL136W
    		•  The BioGRID Database Seperator Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLN3
  • WHI1
  • FUN10
  • DAF1
  • YAL040C
    		•  The BioGRID Database Seperator G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Wang H (2009) [11]
    bait Huang D (2009) [28]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIF2
  • EMB1
  • YBR103W
    		•  The BioGRID Database Seperator WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GSG1
  • MUM1
  • TRS85
  • YDR108W
    		•  The BioGRID Database Seperator Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIK1
  • YMR198W
    		•  The BioGRID Database Seperator Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAM37
  • MAS37
  • TOM37
  • PET3027
  • YMR060C
    		•  The BioGRID Database Seperator Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex; required for the sorting of some proteins to the outer membrane after import by the TOM complex
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GTR1
  • YML121W
    		•  The BioGRID Database Seperator Cytoplasmic GTP binding protein and negative regulator, with homolog Gtr2p, of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport; has homology to human RagA and RagB
    Gene Ontology: [View List]
    Positive Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS161
  • FUS7
  • END6
  • SPE161
  • YCR009C
    		•  The BioGRID Database Seperator Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LEO1
  • YOR123C
    		•  The BioGRID Database Seperator Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MON2
  • YSL2
  • YNL297C
    		•  The BioGRID Database Seperator Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
    Gene Ontology: [View List]
    Positive Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE2
  • CPS60
  • YLR015W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOT1
  • PCH1
  • YDR440W
    		•  The BioGRID Database Seperator Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Phenotypic Suppression
    bait Verzijlbergen KF (2009) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS21
  • YPT21
  • YPT51
  • VPS12
  • YOR089C
    		•  The BioGRID Database Seperator GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC66
  • HSS1
  • SEC71
  • YBR171W
    		•  The BioGRID Database Seperator Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DEG1
  • PUS3
  • YFL001W
    		•  The BioGRID Database Seperator Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm
    Gene Ontology: [View List]
    Positive Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRM6
  • YML047C
    		•  The BioGRID Database Seperator Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IES1
  • YFL013C
    		•  The BioGRID Database Seperator Subunit of the INO80 chromatin remodeling complex
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUR1
  • LPE15
  • CSG1
  • BCL21
  • YPL057C
    		•  The BioGRID Database Seperator Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBR2
  • YLR024C
    		•  The BioGRID Database Seperator Cytoplasmic ubiquitin-protein ligase (E3)
    Gene Ontology: [View List]
    Dosage Lethality
    hit Daniel J (2007) [13]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OPI3
  • PEM2
  • YJR073C
    		•  The BioGRID Database Seperator Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YME1
  • YTA11
  • OSD1
  • YPR024W
    		•  The BioGRID Database Seperator Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT8
  • YLR055C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Ingvarsdottir K (2005) [143]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIR3
  • STE8
  • CMT1
  • MAR2
  • YLR442C
    		•  The BioGRID Database Seperator Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Smith JS (1999) [4]
    hit Ehrentraut S (2010) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARD1
  • YHR013C
    		•  The BioGRID Database Seperator Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAF9
  • YNL107W
    		•  The BioGRID Database Seperator Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNT1
  • YCR033W
    		•  The BioGRID Database Seperator Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Beltrao P (2009) [835]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSG2
  • CLS2
  • YBR036C
    		•  The BioGRID Database Seperator Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Beeler T (1998) [10]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG3
  • SYR1
  • PSO6
  • YLR056W
    		•  The BioGRID Database Seperator C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Beltrao P (2009) [835]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIR4
  • STE9
  • ASD1
  • UTH2
  • YDR227W
    		•  The BioGRID Database Seperator Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Sun ZW (1999) [7]
    hit Ehrentraut S (2010) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRK1
  • YJL129C
    		•  The BioGRID Database Seperator Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Vidal M (1990) [3]
    bait Vidal M (1991) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP3
  • TOT3
  • HPA1
  • YPL086C
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Kong SE (2005) [113]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ISW2
  • YOR304W
    		•  The BioGRID Database Seperator Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Fazzio TG (2001) [1]
    bait Goldmark JP (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP2
  • TOT2
  • YGR200C
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Kong SE (2005) [113]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP6
  • TOT6
  • HAP3
  • YMR312W
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Kong SE (2005) [113]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACE2
  • YLR131C
    		•  The BioGRID Database Seperator Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Voth WP (2007) [11]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL35A
  • SOS1
  • YDL191W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STO1
  • CBP80
  • GCR3
  • CBC1
  • YMR125W
    		•  The BioGRID Database Seperator Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NRD1
  • YNL251C
    		•  The BioGRID Database Seperator RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COQ6
  • YGR255C
    		•  The BioGRID Database Seperator Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKB2
  • YOR039W
    		•  The BioGRID Database Seperator Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH2
  • SCD3
  • YDR099W
    		•  The BioGRID Database Seperator 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lottersberger F (2007) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC45
  • SLD4
  • YLR103C
    		•  The BioGRID Database Seperator DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT1
  • LPF4
  • BUR3
  • YPL082C
    		•  The BioGRID Database Seperator Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Arnett DR (2008) [91]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJL123C
  • YJL123C
    		•  The BioGRID Database Seperator Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); YJL123C is a non-essential gene
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI5
  • YOR083W
    		•  The BioGRID Database Seperator Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Huang D (2009) [28]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAC1
  • ERN4
  • IRE15
  • YFL031W
    		•  The BioGRID Database Seperator bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Schroeder M (2004) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR1
  • CPH1
  • CYP1
  • YDR155C
    		•  The BioGRID Database Seperator Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Arevalo-Rodriguez M (2000) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS1
  • GRD1
  • LAM1
  • VPL1
  • YKR001C
    		•  The BioGRID Database Seperator Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL33A
  • YPL143W
    		•  The BioGRID Database Seperator N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF4
  • TAF48
  • MPT1
  • TSG2
  • YMR005W
    		•  The BioGRID Database Seperator TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOG1
  • SSK3
  • YLR113W
    		•  The BioGRID Database Seperator Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit De Nadal E (2004) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL17A
  • RPL17
  • YKL180W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GRX5
  • YPL059W
    		•  The BioGRID Database Seperator Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUT1
  • MED5
  • YGL151W
    		•  The BioGRID Database Seperator Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAP2
  • DPP2
  • YHR028C
    		•  The BioGRID Database Seperator Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXK1
  • YFR053C
    		•  The BioGRID Database Seperator Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAJ1
  • YER048C
    		•  The BioGRID Database Seperator Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAP1
  • YER047C
    		•  The BioGRID Database Seperator Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR506C
  • YDR506C
    		•  The BioGRID Database Seperator Possible membrane-localized protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TMN3
  • YER113C
    		•  The BioGRID Database Seperator Non-essential golgi localized protein of unknown function; contains niine potential transmembrane domains and has similarity to the endosomal protein, Emp70p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTR1
  • YER139C
    		•  The BioGRID Database Seperator Putative protein of unknown function; YER139C has been shown to be required for growth at high temperatures; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIP3
  • YGL216W
    		•  The BioGRID Database Seperator Kinesin-related motor protein involved in mitotic spindle positioning
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN20
  • YFR009W
    		•  The BioGRID Database Seperator Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MIP6
  • YHR015W
    		•  The BioGRID Database Seperator Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCS6
  • YGL210W-A
  • TUC1
  • YGL211W
    		•  The BioGRID Database Seperator Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHO2
  • PEM1
  • YGR157W
    		•  The BioGRID Database Seperator Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
    Gene Ontology: [View List]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHL042W
  • YHL042W
    		•  The BioGRID Database Seperator Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM34
  • YHL043W
    		•  The BioGRID Database Seperator Putative protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSE1
  • YHL002W
    		•  The BioGRID Database Seperator Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SBP1
  • SSB1
  • SSBR1
  • YHL034C
    		•  The BioGRID Database Seperator Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL8A
  • MAK7
  • YHL033C
    		•  The BioGRID Database Seperator Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
    Gene Ontology: [View List]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHL012W
  • YHL012W
    		•  The BioGRID Database Seperator Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHL017W
  • YHL017W
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RMD11
  • YHL023C
    		•  The BioGRID Database Seperator Protein required for sporulation
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEX29
  • YDR479C
    		•  The BioGRID Database Seperator Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENO1
  • HSP48
  • YGR254W
    		•  The BioGRID Database Seperator Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
    Gene Ontology: [View List]
    Negative Genetic
    hit