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BioGRID | Network Layout for CUE1 for Saccharomyces cerevisiae
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CUE1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: KIS4, YMR264W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Cue1p|Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with CUE1

CUE1 was identified with 19 protein interactions and 29 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 QRI8
  • UBC7
  • YMR022W
    		•  The BioGRID Database Seperator Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
    Gene Ontology: [View List]
    Co-purification
    hit Biederer T (1997)
    Affinity Capture-Western
    hit Ravid T (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG25
  • YGR060W
    		•  The BioGRID Database Seperator C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol|Erg25p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSH1
  • YBR283C
    		•  The BioGRID Database Seperator Ssh1p|Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS2
  • MMC1
  • YGL075C
    		•  The BioGRID Database Seperator Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p|Mps2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait McBratney S (2002)
    Synthetic Rescue
    bait McBratney S (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL4
  • HRD4
  • YBR170C
    		•  The BioGRID Database Seperator Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation|Npl4p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Hitchcock AL (2003)
    bait Auld KL (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NDC1
  • YML031W
    		•  The BioGRID Database Seperator Ndc1p|Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait McBratney S (2002)
    Synthetic Rescue
    bait McBratney S (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT1
  • CIM5
  • YTA3
  • YKL145W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p|Rpt1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ng W (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSM4
  • DOA10
  • KIS3
  • YIL030C
    		•  The BioGRID Database Seperator Ssm4p|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Carvalho P (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POM34
  • YLR018C
    		•  The BioGRID Database Seperator Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex|Pom34p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GPI2
  • GCR4
  • YPL076W
    		•  The BioGRID Database Seperator Gpi2p|Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHL042W
  • YHL042W
    		•  The BioGRID Database Seperator Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins|Yhl042wp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOM6
  • ISP6
  • MOM8B
  • YOR045W
    		•  The BioGRID Database Seperator Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex|Tom6p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPO1
  • YLL028W
    		•  The BioGRID Database Seperator Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane|Tpo1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA10
  • YHR039C-B
  • YHR039C-A
    		•  The BioGRID Database Seperator Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification|Vma10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAN1
  • YEL063C
    		•  The BioGRID Database Seperator Can1p|Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS73
  • YGL104C
    		•  The BioGRID Database Seperator Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family|Vps73p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COS8
  • YHL048W
    		•  The BioGRID Database Seperator Cos8p|Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UIP3
  • YAR027W
    		•  The BioGRID Database Seperator Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family|Uip3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WBP1
  • YEL002C
    		•  The BioGRID Database Seperator Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum|Wbp1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAL31
  • YBR298C
    		•  The BioGRID Database Seperator Mal31p|Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC1
  • YJR010C-A
    		•  The BioGRID Database Seperator Spc1p|Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC28
  • ANU2
  • YIL076W
    		•  The BioGRID Database Seperator Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth|Sec28p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OPI3
  • PEM2
  • YJR073C
    		•  The BioGRID Database Seperator Opi3p|Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMG1
  • YML075C
    		•  The BioGRID Database Seperator Hmg1p|One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae; protein coding
    Gene Ontology: [View List]
    Dosage Lethality
    hit Loertscher J (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RGP1
  • YDR137W
    		•  The BioGRID Database Seperator Rgp1p|Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIC1
  • YLR039C
    		•  The BioGRID Database Seperator Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes|Ric1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC4
  • EAF2
  • GOD1
  • YGR002C
    		•  The BioGRID Database Seperator Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex|Swc4p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LHS1
  • CER1
  • SSI1
  • YKL073W
    		•  The BioGRID Database Seperator Lhs1p|Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Esa1p|Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP4
  • ACT3
  • YJL081C
    		•  The BioGRID Database Seperator Arp4p|Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMT2
  • FUN25
  • YAL023C
    		•  The BioGRID Database Seperator Pmt2p|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Nakatsukasa K (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHO2
  • PEM1
  • YGR157W
    		•  The BioGRID Database Seperator Cho2p|Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MATALPHA2
  • ALPHA2
  • YCR039C
    		•  The BioGRID Database Seperator Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette|Matalpha2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Ravid T (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRD3
  • YLR207W
    		•  The BioGRID Database Seperator Hrd3p|Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Plemper RK (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG11
  • CYP51
  • YHR007C
    		•  The BioGRID Database Seperator Erg11p|Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Parsons AB (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAC1
  • ERN4
  • IRE15
  • YFL031W
    		•  The BioGRID Database Seperator Hac1p|bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE24
  • AFC1
  • PIO2
  • YJR117W
    		•  The BioGRID Database Seperator Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans|Ste24p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MGA2
  • YIR033W
    		•  The BioGRID Database Seperator ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting|Mga2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNL181W
  • YNL181W
    		•  The BioGRID Database Seperator Putative oxidoreductase; required for cell viability|Ynl181wp; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRE1
  • ERN1
  • YHR079C
    		•  The BioGRID Database Seperator Ire1p|Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC63
  • PTL1
  • YOR254C
    		•  The BioGRID Database Seperator Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER|Sec63p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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