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BioGRID | Network Layout for VTI1 for Saccharomyces cerevisiae
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VTI1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YMR197C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 9 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with VTI1

VTI1 was identified with 80 protein interactions and 15 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 VAM3
  • PTH1
  • YOR106W
    		•  The BioGRID Database Seperator Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wang Y (2001) [5]
    bait/hit Ungermann C (1999) [22]
    bait Rohde J (2003) [3]
    hit Veit M (2001) [6]
    bait Holthuis JC (1998) [12]
    bait Wang CW (2003) [22]
    hit Laage R (2001) [6]
    bait/hit Collins KM (2005) [62]
    Reconstituted Complex
    hit Tsui MM (2001) [28]
    bait Fukuda R (2000) [5]
    Co-purification
    bait Ungermann C (1999) [22]
    Co-fractionation
    bait Wang CW (2003) [22]
    bait Roy R (2006) [6]
    Dosage Rescue
    hit Fischer von Mollard G (1999) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKT6
  • YKL196C
    		•  The BioGRID Database Seperator Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Ungermann C (1999) [22]
    hit Lupashin VV (1997) [10]
    hit Laage R (2001) [6]
    hit Dietrich LE (2005) [4]
    hit Collins KM (2005) [62]
    Reconstituted Complex
    hit Tsui MM (2001) [28]
    hit Tsui MM (2000) [33]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Co-purification
    hit Collins KM (2005) [62]
    Dosage Rescue
    hit Lupashin VV (1997) [10]
    hit Dilcher M (2001) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM7
  • VPS43
  • YGL212W
    		•  The BioGRID Database Seperator Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Ungermann C (1999) [22]
    hit Laage R (2001) [6]
    bait Collins KM (2005) [62]
    Reconstituted Complex
    bait Tsui MM (2001) [28]
    bait Fukuda R (2000) [5]
    bait Jun Y (2006) [6]
    Co-purification
    bait/hit Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SED5
  • YLR026C
    		•  The BioGRID Database Seperator cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Lupashin VV (1997) [10]
    bait von Mollard GF (1997) [5]
    bait Holthuis JC (1998) [12]
    Reconstituted Complex
    hit Tsui MM (2001) [28]
    hit Tsui MM (2000) [33]
    Dosage Rescue
    hit Lupashin VV (1997) [10]
    hit von Mollard GF (1997) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC17
  • RNS3
  • YBL050W
    		•  The BioGRID Database Seperator Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Ungermann C (1999) [22]
    bait Lupashin VV (1997) [10]
    hit Veit M (2001) [6]
    hit Coe JG (1999) [8]
    hit Collins KM (2005) [62]
    Co-purification
    hit Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TLG1
  • YDR468C
    		•  The BioGRID Database Seperator Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Bryant NJ (2003) [6]
    bait Coe JG (1999) [8]
    bait Holthuis JC (1998) [12]
    Reconstituted Complex
    hit Paumet F (2001) [3]
    hit Tsui MM (2001) [28]
    Co-purification
    bait Paumet F (2005) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NYV1
  • MAM2
  • YLR093C
    		•  The BioGRID Database Seperator v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Ungermann C (1999) [22]
    hit Veit M (2001) [6]
    hit Laage R (2001) [6]
    hit Collins KM (2005) [62]
    Co-purification
    hit Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP12
  • VPT13
  • VPL6
  • VPS6
  • YOR036W
    		•  The BioGRID Database Seperator Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit von Mollard GF (1997) [5]
    Reconstituted Complex
    bait Paumet F (2004) [2]
    Dosage Rescue
    hit Fischer von Mollard G (1999) [2]
    hit von Mollard GF (1997) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TLG2
  • YOL018C
    		•  The BioGRID Database Seperator Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Bryant NJ (2001) [4]
    bait Holthuis JC (1998) [12]
    Reconstituted Complex
    hit Paumet F (2001) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENT3
  • YJR125C
    		•  The BioGRID Database Seperator Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Chidambaram S (2004) [4]
    Two-hybrid
    hit Chidambaram S (2004) [4]
    Synthetic Lethality
    hit Chidambaram S (2004) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM6
  • VPL22
  • VPS39
  • CVT4
  • YDL077C
    		•  The BioGRID Database Seperator Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Collins KM (2005) [62]
    Co-purification
    bait Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VTI1
  • YMR197C
    		•  The BioGRID Database Seperator Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Tsui MM (2000) [33]
    Co-fractionation
    hit Roy R (2006) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNC2
  • YOR327C
    		•  The BioGRID Database Seperator Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Tsui MM (2001) [28]
    hit Paumet F (2001) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS33
  • CLS14
  • SLP1
  • VAM5
  • YLR396C
    		•  The BioGRID Database Seperator ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Collins KM (2005) [62]
    Co-purification
    bait Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TVP23
  • YDR084C
    		•  The BioGRID Database Seperator Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
    Gene Ontology: [View List]
    Dosage Rescue
    hit Stein IS (2009) [3]
    Synthetic Lethality
    hit Stein IS (2009) [3]
    Phenotypic Enhancement
    hit Stein IS (2009) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM1
  • SRO1
  • YBR200W
    		•  The BioGRID Database Seperator Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
    Gene Ontology: [View List]
    Co-fractionation
    bait Xu H (2006) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BTN2
  • YGR142W
    		•  The BioGRID Database Seperator v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Kama R (2007) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MBP1
  • YDL056W
    		•  The BioGRID Database Seperator Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
    Gene Ontology: [View List]
    Two-hybrid
    hit Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AKR1
  • YDR264C
    		•  The BioGRID Database Seperator Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS16
  • VAM9
  • SVL6
  • VPT16
  • YPL045W
    		•  The BioGRID Database Seperator Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SYN8
  • SLT2
  • UIP2
  • YAL014C
    		•  The BioGRID Database Seperator Endosomal SNARE related to mammalian syntaxin 8
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lewis MJ (2002) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS45
  • VPL28
  • STT10
  • YGL095C
    		•  The BioGRID Database Seperator Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC8
  • YEB3
  • YEL013W
    		•  The BioGRID Database Seperator Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Veit M (2001) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS41
  • VAM2
  • CVT8
  • SVL2
  • YDR080W
    		•  The BioGRID Database Seperator Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP3
  • VPS18
  • VAM8
  • VPT18
  • YLR148W
    		•  The BioGRID Database Seperator Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP5
  • VPT11
  • END1
  • VPL9
  • YMR231W
    		•  The BioGRID Database Seperator Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VTS1
  • YOR359W
    		•  The BioGRID Database Seperator Post-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic
    Gene Ontology: [View List]
    Dosage Rescue
    hit Dilcher M (2001) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFT1
  • YKL006C-A
    		•  The BioGRID Database Seperator Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
    Gene Ontology: [View List]
    Dosage Rescue
    bait/hit Lupashin VV (1997) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLY1
  • YDR189W
    		•  The BioGRID Database Seperator Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
    Gene Ontology: [View List]
    Dosage Rescue
    hit Lupashin VV (1997) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENT5
  • YDR153C
    		•  The BioGRID Database Seperator Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Chidambaram S (2004) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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