The BioGRID Database Seperator
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BioGRID | Network Layout for SGS1 for Saccharomyces cerevisiae
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SGS1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YMR190C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 27 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SGS1

SGS1 was identified with 45 protein interactions and 499 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 TOP3
  • EDR1
  • YLR234W
    		•  The BioGRID Database Seperator DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Bennett RJ (2000) [3]
    bait/hit Fricke WM (2001) [5]
    hit Wang TF (2002) [3]
    bait/hit Mullen JR (2005) [15]
    bait Chen CF (2007) [5]
    Reconstituted Complex
    bait Fricke WM (2001) [5]
    Two-hybrid
    bait/hit Onodera R (2002) [5]
    hit Ui A (2001) [1]
    hit Weinstein J (2008) [11]
    bait Sollier J (2009) [12]
    Co-fractionation
    bait Fricke WM (2001) [5]
    Dosage Rescue
    hit Fricke WM (2001) [5]
    Synthetic Growth Defect
    bait Mullen JR (2000) [2]
    hit Onodera R (2002) [5]
    Synthetic Rescue
    bait Oakley TJ (2002) [2]
    bait Shor E (2002) [10]
    bait Onodera R (2002) [5]
    bait Watt PM (1996) [1]
    bait Watt PM (1995) [1]
    bait Gangloff S (1994) [1]
    bait Bjergbaek L (2005) [7]
    bait Wagner M (2006) [10]
    bait Lai MS (2007) [4]
    bait Chakraverty RK (2001) [1]
    Phenotypic Enhancement
    hit Ui A (2005) [5]
    bait Weinstein J (2008) [11]
    bait Bernstein KA (2009) [2]
    Phenotypic Suppression
    bait Weinstein J (2008) [11]
    Dosage Growth Defect
    hit Bennett RJ (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRS2
  • HPR5
  • YJL092W
    		•  The BioGRID Database Seperator DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
    Gene Ontology: [View List]
    Two-hybrid
    bait Chiolo I (2005) [86]
    Affinity Capture-Western
    bait/hit Chiolo I (2005) [86]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Klein HL (2001) [7]
    hit Mullen JR (2001) [21]
    hit Gangloff S (2000) [3]
    hit Lee SK (1999) [1]
    bait Krejci L (2004) [7]
    bait Xu H (2004) [25]
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    hit Lo YC (2006) [1]
    hit Weinstein J (2008) [11]
    bait Mankouri HW (2002) [2]
    Dosage Rescue
    bait/hit Ira G (2003) [4]
    bait Panico ER (2009) [17]
    bait Mankouri HW (2002) [2]
    Phenotypic Enhancement
    hit McVey M (2001) [15]
    hit Duno M (2000) [1]
    hit Schmidt KH (2006) [11]
    hit Putnam CD (2009) [35]
    Synthetic Growth Defect
    bait Fabre F (2002) [4]
    bait Chiolo I (2005) [86]
    hit Dixon SJ (2008) [1412]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MUS81
  • SLX3
  • YDR386W
    		•  The BioGRID Database Seperator Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    bait Bastin-Shanower SA (2003) [1]
    bait Fabre F (2002) [4]
    hit Mullen JR (2001) [21]
    bait Bellaoui M (2003) [57]
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    hit Ii M (2007) [2]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Phenotypic Enhancement
    hit Ii M (2007) [2]
    hit Jessop L (2008) [1]
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD51
  • MUT5
  • YER095W
    		•  The BioGRID Database Seperator Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
    Gene Ontology: [View List]
    Two-hybrid
    bait Wu L (2001) [4]
    Synthetic Rescue
    hit McVey M (2001) [15]
    hit Gangloff S (2000) [3]
    hit Yamana Y (2005) [5]
    hit Budd ME (2005) [52]
    hit Weinstein J (2008) [11]
    hit Chen YH (2009) [19]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Phenotypic Enhancement
    hit Schmidt KH (2006) [21]
    bait Schmidt KH (2006) [11]
    hit Kerrest A (2009) [4]
    Phenotypic Suppression
    hit Schmidt KH (2006) [21]
    hit Schmidt KH (2006) [11]
    hit Mankouri HW (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RMI1
  • NCE4
  • YPL024W
    		•  The BioGRID Database Seperator Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Mullen JR (2005) [15]
    bait Chang M (2005) [17]
    Reconstituted Complex
    bait Mullen JR (2005) [15]
    Co-fractionation
    bait Chang M (2005) [17]
    Synthetic Rescue
    bait Mullen JR (2005) [15]
    bait Chang M (2005) [17]
    bait Lai MS (2007) [4]
    Positive Genetic
    bait Collins SR (2007) [14430]
    Phenotypic Enhancement
    bait Bernstein KA (2009) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS4
  • SLX2
  • YBR100W
  • YBR098W
    		•  The BioGRID Database Seperator Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    bait Fabre F (2002) [4]
    hit Mullen JR (2001) [21]
    bait Bellaoui M (2003) [57]
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Phenotypic Enhancement
    hit Oh SD (2008) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX5
  • HEX3
  • YDL013W
    		•  The BioGRID Database Seperator Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Mullen JR (2001) [21]
    hit Pan X (2004) [323]
    bait Pan X (2006) [5331]
    hit Ii T (2007) [22]
    hit Ii T (2007) [6]
    hit Mullen JR (2008) [4]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Dixon SJ (2008) [1412]
    Phenotypic Enhancement
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOP1
  • MAK17
  • MAK1
  • YOL006C
    		•  The BioGRID Database Seperator Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    hit Onodera R (2002) [5]
    Synthetic Growth Defect
    hit Bennett RJ (2000) [3]
    bait Mullen JR (2000) [2]
    hit Torres JZ (2004) [13]
    hit Weinstein J (2008) [11]
    bait Dixon SJ (2008) [1412]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT107
  • ESC4
  • YHR154W
    		•  The BioGRID Database Seperator Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Two-hybrid
    bait Chin JK (2006) [21]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    hit Zappulla DC (2006) [4]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Phenotypic Enhancement
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLH1
  • PMS2
  • YMR167W
    		•  The BioGRID Database Seperator Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Wang TF (2002) [3]
    Two-hybrid
    bait Argueso JL (2003) [6]
    bait Argueso JL (2002) [4]
    bait/hit Dherin C (2009) [29]
    Protein-peptide
    bait Dherin C (2009) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX4
  • YLR135W
    		•  The BioGRID Database Seperator Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Kaliraman V (2002) [1]
    hit Mullen JR (2001) [21]
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Dixon SJ (2008) [1412]
    Phenotypic Enhancement
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESC2
  • YDR363W
    		•  The BioGRID Database Seperator Protein involved in mating-type locus silencing, interacts with Sir2p; probably functions to recruit or stabilize Sir proteins
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    bait Sollier J (2009) [12]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Phenotypic Enhancement
    bait Mankouri HW (2009) [1]
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRM3
  • RTT104
  • YHR031C
    		•  The BioGRID Database Seperator DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    bait Torres JZ (2004) [13]
    Synthetic Growth Defect
    bait Schmidt KH (2004) [5]
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Phenotypic Enhancement
    bait Schmidt KH (2006) [11]
    hit Putnam CD (2009) [35]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRC1
  • YCL060C
  • YCL061C
    		•  The BioGRID Database Seperator S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    hit Ooi SL (2003) [2]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    hit Dixon SJ (2008) [1412]
    Phenotypic Enhancement
    hit Bjergbaek L (2005) [7]
    hit Putnam CD (2009) [35]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD53
  • MEC2
  • SPK1
  • LSD1
  • YPL153C
    		•  The BioGRID Database Seperator Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
    Gene Ontology: [View List]
    Co-localization
    hit Frei C (2000) [3]
    Affinity Capture-Western
    bait Bjergbaek L (2005) [7]
    Two-hybrid
    hit Bjergbaek L (2005) [7]
    Phenotypic Enhancement
    bait Myung K (2002) [33]
    hit Putnam CD (2009) [35]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX8
  • YER116C
    		•  The BioGRID Database Seperator Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Mullen JR (2001) [21]
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    hit Ii T (2007) [6]
    hit Mullen JR (2008) [4]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Phenotypic Enhancement
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD27
  • ERC11
  • FEN1
  • RTH1
  • YKL113C
    		•  The BioGRID Database Seperator 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    bait Loeillet S (2005) [127]
    bait/hit Pan X (2006) [5331]
    Phenotypic Suppression
    hit Ringvoll J (2007) [2]
    Phenotypic Enhancement
    hit Ringvoll J (2007) [2]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EXO1
  • DHS1
  • YOR033C
    		•  The BioGRID Database Seperator 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Phenotypic Enhancement
    bait Gravel S (2008) [1]
    hit Putnam CD (2009) [35]
    Synthetic Lethality
    hit Lu CY (2009) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX1
  • YBR228W
    		•  The BioGRID Database Seperator Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Mullen JR (2001) [21]
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Phenotypic Enhancement
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAE2
  • COM1
  • YGL175C
    		•  The BioGRID Database Seperator Protein with a role in accurate meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Phenotypic Enhancement
    hit Putnam CD (2009) [35]
    bait Bonetti D (2009) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WSS1
  • YHR134W
    		•  The BioGRID Database Seperator Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    bait O'Neill BM (2004) [17]
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Phenotypic Enhancement
    bait O'Neill BM (2004) [17]
    Synthetic Growth Defect
    hit Dixon SJ (2008) [1412]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSM3
  • YMR048W
    		•  The BioGRID Database Seperator Protein required for accurate chromosome segregation during meiosis
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    hit Dixon SJ (2008) [1412]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASF1
  • CIA1
  • YJL115W
    		•  The BioGRID Database Seperator Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    Phenotypic Enhancement
    hit Myung K (2003) [31]
    bait Kats ES (2006) [11]
    hit Schmidt KH (2006) [21]
    hit Putnam CD (2009) [35]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD24
  • YER173W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Myung K (2002) [33]
    hit Frei C (2000) [3]
    hit Schmidt KH (2006) [21]
    bait Bjergbaek L (2005) [7]
    hit Fu Y (2008) [10]
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL32
  • YJR043C
    		•  The BioGRID Database Seperator Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    bait Hanna M (2007) [39]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPH1
  • YIR002C
    		•  The BioGRID Database Seperator Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuerer KA (2004) [7]
    bait Prakash R (2009) [5]
    hit Putnam CD (2009) [35]
    bait Tay YD (2010) [2]
    Dosage Rescue
    bait Panico ER (2009) [17]
    Synthetic Growth Defect
    hit Chen YH (2009) [19]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIF1
  • TST1
  • YML061C
    		•  The BioGRID Database Seperator DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Myung K (2002) [33]
    bait Smith S (2008) [10]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait Wagner M (2006) [10]
    Synthetic Rescue
    bait Wagner M (2006) [10]
    Dosage Lethality
    hit Wagner M (2006) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD52
  • YML032C
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
    Gene Ontology: [View List]
    Synthetic Rescue
    hit McVey M (2001) [15]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    bait Alvaro D (2007) [25]
    Dosage Rescue
    hit Sacher M (2006) [3]
    Phenotypic Suppression
    hit Kerrest A (2009) [4]
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRE11
  • XRS4
  • NGS1
  • RAD58
  • YMR224C
    		•  The BioGRID Database Seperator Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Chiolo I (2005) [86]
    Synthetic Growth Defect
    bait Chiolo I (2005) [86]
    bait/hit Pan X (2006) [5331]
    Phenotypic Enhancement
    hit Ui A (2005) [5]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HST3
  • YOR025W
    		•  The BioGRID Database Seperator Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MGS1
  • YNL218W
    		•  The BioGRID Database Seperator Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    Phenotypic Enhancement
    bait Branzei D (2002) [1]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIA2
  • YOR29-31
  • YOR080W
    		•  The BioGRID Database Seperator Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait Blake D (2006) [61]
    bait Dixon SJ (2008) [1412]
    Synthetic Lethality
    bait/hit Pan X (2006) [5331]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUN1
  • YDL101C
    		•  The BioGRID Database Seperator Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    Phenotypic Enhancement
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD50
  • YNL250W
    		•  The BioGRID Database Seperator Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    Synthetic Growth Defect
    bait McVey M (2001) [15]
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    Synthetic Rescue
    hit Huang P (2001) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TSA1
  • TPX1
  • ZRG14
  • YML028W
    		•  The BioGRID Database Seperator Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Huang ME (2005) [15]
    bait/hit Pan X (2006) [5331]
    Phenotypic Enhancement
    hit Schmidt KH (2006) [21]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELG1
  • RTT110
  • YOR144C
    		•  The BioGRID Database Seperator Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Banerjee S (2004) [17]
    Synthetic Lethality
    bait Bellaoui M (2003) [57]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PBY1
  • YBR094W
    		•  The BioGRID Database Seperator Putative tubulin tyrosine ligase associated with P-bodies
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001) [338]
    bait/hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    hit Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD16
  • PSO5
  • YBR114W
    		•  The BioGRID Database Seperator Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Saffi J (2001) [4]
    Two-hybrid
    bait Saffi J (2001) [4]
    Phenotypic Enhancement
    bait Saffi J (2001) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNH202
  • YDR279W
    		•  The BioGRID Database Seperator Ribonuclease H2 subunit, required for RNase H2 activity
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Ii M (2005) [4]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD1
  • LPB9
  • YPL022W
    		•  The BioGRID Database Seperator Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait McVey M (2001) [15]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Phenotypic Suppression
    bait Ui A (2007) [6]
    Phenotypic Enhancement
    bait Vance JR (2002) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD9
  • YDR217C
    		•  The BioGRID Database Seperator DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Myung K (2002) [33]
    hit Schmidt KH (2006) [21]
    hit McVey M (2001) [15]
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID22
  • YLR373C
    		•  The BioGRID Database Seperator Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKU70
  • HDF1
  • NES24
  • YMR284W
    		•  The BioGRID Database Seperator Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Yamana Y (2005) [5]
    Dosage Rescue
    hit Yamana Y (2005) [5]
    Phenotypic Enhancement
    hit Ui A (2005) [5]
    bait Smith S (2008) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOF1
  • YNL273W
    		•  The BioGRID Database Seperator Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Phenotypic Enhancement
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNA2
  • WEB2
  • YHR164C
    		•  The BioGRID Database Seperator Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Budd ME (2000) [2]
    bait Hoopes LL (2002) [3]
    Synthetic Lethality
    bait Weitao T (2003) [1]
    bait Budd ME (2005) [52]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMC6
  • RHC18
  • YLR383W
    		•  The BioGRID Database Seperator Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18
    Gene Ontology: [View List]
    Co-fractionation
    bait Sollier J (2009) [12]
    Synthetic Growth Defect
    bait Torres-Rosell J (2005) [7]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSH2
  • PMS5
  • YOL090W
    		•  The BioGRID Database Seperator Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Myung K (2001) [1]
    Synthetic Growth Defect
    bait Onoda F (2004) [1]
    Phenotypic Suppression
    bait Tay YD (2010) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSM2
  • YIL132C
    		•  The BioGRID Database Seperator Protein required for accurate chromosome segregation during meiosis
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Shor E (2005) [16]
    Phenotypic Enhancement
    hit Shor E (2005) [16]
    Phenotypic Suppression
    hit Mankouri HW (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNH203
  • YLR154C
    		•  The BioGRID Database Seperator Ribonuclease H2 subunit, required for RNase H2 activity
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Dixon SJ (2008) [1412]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNH201
  • RNH35
  • YNL072W
    		•  The BioGRID Database Seperator Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; cooperates with Rad27p nuclease
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC4
  • YBR082C
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP84
  • YDL116W
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP133
  • RAT3
  • YKR082W
    		•  The BioGRID Database Seperator Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Synthetic Lethality
    bait Loeillet S (2005) [127]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD17
  • YOR368W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Myung K (2002) [33]
    bait Fu Y (2008) [10]
    Synthetic Rescue
    hit Miyajima A (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS1
  • SLM6
  • RTT108
  • YPR164W
    		•  The BioGRID Database Seperator Protein likely involved in protection against replication-dependent DNA damage; mutants are sensitive to methyl methanesulfonate (MMS); implicated in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    Phenotypic Suppression
    hit Ui A (2007) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHU1
  • YHL006C
    		•  The BioGRID Database Seperator Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Shor E (2005) [16]
    Phenotypic Enhancement
    hit Shor E (2005) [16]
    Phenotypic Suppression
    hit Mankouri HW (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSY3
  • YLR376C
    		•  The BioGRID Database Seperator Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Shor E (2005) [16]
    hit Ball LG (2009) [18]
    Phenotypic Suppression
    hit Mankouri HW (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF18
  • CHL12
  • YMR078C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004) [3873]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    Phenotypic Enhancement
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOD1
  • CRS4
  • YJR104C
    		•  The BioGRID Database Seperator Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001) [338]
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF4
  • CHL15
  • POB1
  • YPR135W
    		•  The BioGRID Database Seperator Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EST2
  • YLR318W
    		•  The BioGRID Database Seperator Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Cohen H (2001) [1]
    hit Myung K (2002) [33]
    Synthetic Lethality
    hit Huang P (2001) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEC3
  • PSO9
  • PIP3
  • YLR288C
    		•  The BioGRID Database Seperator DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Myung K (2002) [33]
    hit Schmidt KH (2006) [21]
    Synthetic Growth Defect
    bait Schmidt KH (2006) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMT3
  • YDR510W
    		•  The BioGRID Database Seperator Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
    Gene Ontology: [View List]
    Two-hybrid
    hit Sollier J (2009) [12]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLH3
  • YPL164C
    		•  The BioGRID Database Seperator Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Wang TF (2002) [3]
    Phenotypic Suppression
    bait Oh SD (2007) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC7
  • SAS1
  • LSD6
  • YDL017W
    		•  The BioGRID Database Seperator DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCC1
  • YCL016C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPH1
  • YLR312C-B
  • YLR313C
    		•  The BioGRID Database Seperator Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POP2
  • CAF1
  • YNR052C
    		•  The BioGRID Database Seperator RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MTF1
  • YMR228W
    		•  The BioGRID Database Seperator Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCS1
  • LYS7
  • YMR038C
    		•  The BioGRID Database Seperator Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Pan X (2004) [323]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL3
  • MTR13
  • MTS1
  • NAB1
  • YDR432W
    		•  The BioGRID Database Seperator RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP170
  • NLE3
  • YBL079W
    		•  The BioGRID Database Seperator Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSM1
  • YCR086W
    		•  The BioGRID Database Seperator Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHU2
  • YDR078C
    		•  The BioGRID Database Seperator Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Shor E (2005) [16]
    Phenotypic Suppression
    hit Mankouri HW (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UME6
  • NIM2
  • CAR80
  • RIM16
  • YDR207C
    		•  The BioGRID Database Seperator Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEL1
  • YBL088C
    		•  The BioGRID Database Seperator Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schmidt KH (2006) [21]
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP8
  • YOR141C
    		•  The BioGRID Database Seperator Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2006) [5331]
    Phenotypic Enhancement
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEC1
  • ESR1
  • SAD3
  • YBR136W
    		•  The BioGRID Database Seperator Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schmidt KH (2006) [21]
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RLF2
  • CAC1
  • YPR018W
    		•  The BioGRID Database Seperator Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Myung K (2003) [31]
    hit Schmidt KH (2006) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FOB1
  • HRM1
  • YDR110W
    		•  The BioGRID Database Seperator Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Budd ME (2005) [52]
    hit McVey M (2001) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SML1
  • YML058W
    		•  The BioGRID Database Seperator Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schmidt KH (2006) [21]
    hit Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM1
  • SPB8
  • YJL124C
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD54
  • XRS1
  • YGL163C
    		•  The BioGRID Database Seperator DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Pan X (2006) [5331]
    Phenotypic Suppression
    hit Mankouri HW (2007) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD57
  • YDR004W
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit McVey M (2001) [15]
    hit Weinstein J (2008) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     XRS2
  • YDR369C
    		•  The BioGRID Database Seperator Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    bait/hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC8
  • YJR057W
    		•  The BioGRID Database Seperator Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR520C
  • YDR520C
    		•  The BioGRID Database Seperator Putative transcription factor; contains the (Zn(II)2Cys6 motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and sensitive to caffeine
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Pan X (2004) [323]
    hit Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Mitchell L (2008) [313]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC9
  • YDL064W
    		•  The BioGRID Database Seperator SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
    Gene Ontology: [View List]
    Two-hybrid
    hit Sollier J (2009) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPL141C
  • YPL141C
    		•  The BioGRID Database Seperator Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STU2
  • YLR045C
    		•  The BioGRID Database Seperator Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
    Gene Ontology: [View List]
    Two-hybrid
    bait Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD27
  • URI1
  • YFL023W
    		•  The BioGRID Database Seperator Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by the TOR kinase; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
    Gene Ontology: [View List]
    Two-hybrid
    bait Tronnersjoe S (2007) [37]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLH1
  • FCC2
  • HNPCC
  • hMLH1
    		•  The BioGRID Database Seperator mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Dherin C (2009) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIS1
  • YDR096W
    		•  The BioGRID Database Seperator JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
    Gene Ontology: [View List]
    Two-hybrid
    bait Tronnersjoe S (2007) [37]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSH6
  • PMS3
  • YDR097C
    		•  The BioGRID Database Seperator Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB5
  • YPR120C
    		•  The BioGRID Database Seperator B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KSP1
  • YHR082C
    		•  The BioGRID Database Seperator Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP45
  • FUN20
  • YAL032C
    		•  The BioGRID Database Seperator Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
    Gene Ontology: [View List]
    Two-hybrid
    bait Albers M (2003) [52]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD3
  • SAF35
  • CPS30
  • YBR175W
    		•  The BioGRID Database Seperator Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK2
  • YNL154C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLM3
  • MTU1
  • MTO2
  • YDL033C
    		•  The BioGRID Database Seperator tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
    Gene Ontology: [View List]
    Positive Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT1
  • SIN2
  • BUR5
  • YBR010W
    		•  The BioGRID Database Seperator One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KEX2
  • QDS1
  • VMA45
  • SRB1
  • YNL238W
    		•  The BioGRID Database Seperator Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEC1
  • ROC1
  • YBR083W
    		•  The BioGRID Database Seperator Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member
    Gene Ontology: [View List]
    Positive Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL3
  • HPR6
  • CDC2
  • TEX1
  • YDL102W
    		•  The BioGRID Database Seperator Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPO11
  • YHL022C
    		•  The BioGRID Database Seperator Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Rockmill B (2006) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC48
  • YDL126C
    		•  The BioGRID Database Seperator ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [