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BioGRID | Network Layout for SPC24 for Saccharomyces cerevisiae
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SPC24

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YMR117C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 20 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SPC24

SPC24 was identified with 114 protein interactions and 101 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 SPC25
  • YER018C
    		•  The BioGRID Database Seperator Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Cheeseman IM (2002) [28]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Janke C (2001) [25]
    hit Le Masson I (2002) [12]
    bait/hit Wigge PA (2001) [20]
    hit Kemmler S (2009) [9]
    Two-hybrid
    hit Le Masson I (2002) [12]
    bait/hit Janke C (2001) [25]
    hit Cho RJ (1998) [29]
    hit Newman JR (2000) [177]
    hit Wong J (2007) [604]
    hit Yu H (2008) [1778]
    Reconstituted Complex
    hit Wei RR (2005) [3]
    hit Wang HW (2008) [3]
    Co-crystal Structure
    hit Wei RR (2006) [1]
    Dosage Rescue
    bait/hit Janke C (2001) [25]
    Synthetic Lethality
    hit Wigge PA (2001) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TID3
  • NDC80
  • HEC1
  • YIL144W
    		•  The BioGRID Database Seperator Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Nekrasov VS (2003) [41]
    bait Janke C (2002) [15]
    hit Cheeseman IM (2002) [28]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Janke C (2001) [25]
    bait/hit Le Masson I (2002) [12]
    bait/hit Wigge PA (2001) [20]
    hit Kemmler S (2009) [9]
    Two-hybrid
    hit Le Masson I (2002) [12]
    hit Cho RJ (1998) [29]
    Reconstituted Complex
    hit Wei RR (2005) [3]
    hit Wang HW (2008) [3]
    Co-fractionation
    bait De Wulf P (2003) [64]
    Dosage Rescue
    bait Janke C (2001) [25]
    Synthetic Lethality
    bait Wigge PA (2001) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUF2
  • YOL069W
    		•  The BioGRID Database Seperator Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Cheeseman IM (2002) [28]
    bait Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    bait/hit Wigge PA (2001) [20]
    hit Kemmler S (2009) [9]
    Two-hybrid
    hit Janke C (2001) [25]
    Reconstituted Complex
    hit Wei RR (2005) [3]
    hit Wang HW (2008) [3]
    Dosage Rescue
    bait Janke C (2001) [25]
    Synthetic Lethality
    bait Wigge PA (2001) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS2
  • MMC1
  • YGL075C
    		•  The BioGRID Database Seperator Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Le Masson I (2002) [12]
    Reconstituted Complex
    bait Le Masson I (2002) [12]
    Two-hybrid
    bait Le Masson I (2003) [8]
    bait Le Masson I (2002) [12]
    bait/hit Newman JR (2000) [177]
    hit Wong J (2007) [604]
    Co-purification
    hit Le Masson I (2002) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC24
  • YMR117C
    		•  The BioGRID Database Seperator Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Cheeseman IM (2002) [28]
    Two-hybrid
    hit Janke C (2001) [25]
    hit Newman JR (2000) [177]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MTW1
  • NSL2
  • DSN3
  • YAL034W-A
    		•  The BioGRID Database Seperator Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Nekrasov VS (2003) [41]
    Affinity Capture-Western
    bait De Wulf P (2003) [64]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM21
  • CTF5
  • YDR318W
    		•  The BioGRID Database Seperator Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules
    Gene Ontology: [View List]
    Two-hybrid
    bait Janke C (2001) [25]
    Synthetic Lethality
    bait Janke C (2001) [25]
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP11
  • RNA11
  • YDL043C
    		•  The BioGRID Database Seperator Subunit of the SF3a splicing factor complex, required for spliceosome assembly
    Gene Ontology: [View List]
    Two-hybrid
    bait Fromont-Racine M (1997) [167]
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CNN1
  • YFR046C
    		•  The BioGRID Database Seperator Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1.
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HDA2
  • PLO2
  • YDR295C
    		•  The BioGRID Database Seperator Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
    Gene Ontology: [View List]
    Two-hybrid
    hit Newman JR (2000) [177]
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMR1
  • YLR190W
    		•  The BioGRID Database Seperator Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Newman JR (2000) [177]
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIR1
  • PIP1
  • YER032W
    		•  The BioGRID Database Seperator Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM36
  • YPR083W
    		•  The BioGRID Database Seperator Protein required for normal mitochondrial morphology and inheritance
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STU1
  • YBL034C
    		•  The BioGRID Database Seperator Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
    Gene Ontology: [View List]
    Co-localization
    bait Ortiz J (2009) [5]
    Synthetic Growth Defect
    hit Ma L (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT103
  • YDR289C
    		•  The BioGRID Database Seperator Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP6
  • YLR085C
    		•  The BioGRID Database Seperator Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAD1
  • YGL086W
    		•  The BioGRID Database Seperator Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKE2
  • GIM1
  • PFD6
  • YLR200W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZIP1
  • YDR285W
    		•  The BioGRID Database Seperator Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAP1
  • YER047C
    		•  The BioGRID Database Seperator Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCD11
  • SUI4
  • YER025W
    		•  The BioGRID Database Seperator Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAS10
  • UTP3
  • YDL153C
    		•  The BioGRID Database Seperator Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAT1
  • MRT1
  • YCR077C
    		•  The BioGRID Database Seperator Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC9
  • YDL064W
    		•  The BioGRID Database Seperator SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YER186C
  • YER186C
    		•  The BioGRID Database Seperator Putative protein of unknown function
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADY3
  • YDL239C
    		•  The BioGRID Database Seperator Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET28
  • YIR017C
    		•  The BioGRID Database Seperator Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM13
  • YBL043W
    		•  The BioGRID Database Seperator Non-essential protein of unknown function
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRP15
  • YPR143W
    		•  The BioGRID Database Seperator Nucleolar protein, constituent of pre-60S ribosomal particles; required for processing of the 27S pre-rRNA at the A2 site to yield 5.8S and 25S rRNA
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS1
  • RPK1
  • YDL028C
    		•  The BioGRID Database Seperator Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Kemmler S (2009) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC105
  • YGL093W
    		•  The BioGRID Database Seperator Protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; forms a complex with Ydr532cp
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Kemmler S (2009) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI1
  • GAM3
  • LPA1
  • ADR6
  • YPL016W
    		•  The BioGRID Database Seperator Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAP5
  • YOR358W
    		•  The BioGRID Database Seperator Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POP6
  • YGR030C
    		•  The BioGRID Database Seperator Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAP4
  • YKL109W
    		•  The BioGRID Database Seperator Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YLR031W
  • YLR031W
    		•  The BioGRID Database Seperator Putative protein of unknown function
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NFI1
  • SIZ2
  • YOR156C
    		•  The BioGRID Database Seperator SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GNA1
  • PAT1
  • YFL017C
    		•  The BioGRID Database Seperator Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAP7
  • YOL028C
    		•  The BioGRID Database Seperator Putative basic leucine zipper (bZIP) transcription factor
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE50
  • YCL032W
    		•  The BioGRID Database Seperator Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL1
  • YBR020W
    		•  The BioGRID Database Seperator Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSK22
  • YCR073C
    		•  The BioGRID Database Seperator MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDS3
  • YGL197W
    		•  The BioGRID Database Seperator Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD6
  • AIP3
  • YLR319C
    		•  The BioGRID Database Seperator Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAM1
  • YGR113W
    		•  The BioGRID Database Seperator Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Shang C (2003) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLT1
  • YDL171C
    		•  The BioGRID Database Seperator NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC110
  • NUF1
  • XCM1
  • YDR356W
    		•  The BioGRID Database Seperator Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
    Gene Ontology: [View List]
    Co-purification
    bait Wigge PA (1998) [37]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DID4
  • VPT14
  • VPS2
  • REN1
  • YKL002W
    		•  The BioGRID Database Seperator Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMC5
  • YOL034W
    		•  The BioGRID Database Seperator Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET18
  • MMS19
  • YIL128W
    		•  The BioGRID Database Seperator DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DSN1
  • YIR010W
    		•  The BioGRID Database Seperator Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Nekrasov VS (2003) [41]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YLR419W
  • YLR419W
    		•  The BioGRID Database Seperator Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPO71
  • YDR104C
    		•  The BioGRID Database Seperator Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPC54
  • YOR177C
    		•  The BioGRID Database Seperator Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
    Gene Ontology: [View List]
    Two-hybrid
    bait Knop M (2000) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD50
  • YNL250W
    		•  The BioGRID Database Seperator Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
    Gene Ontology: [View List]
    Two-hybrid
    hit Newman JR (2000) [177]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMC1
  • CHL10
  • YFL008W
    		•  The BioGRID Database Seperator Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Newman JR (2000) [177]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DYN1
  • PAC6
  • DHC1
  • YKR054C
    		•  The BioGRID Database Seperator Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Newman JR (2000) [177]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC12
  • CLA10
  • PSL7
  • YHR107C
    		•  The BioGRID Database Seperator Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Newman JR (2000) [177]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASN1
  • YPR145W
    		•  The BioGRID Database Seperator Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MID1
  • YNL291C
    		•  The BioGRID Database Seperator N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR130C
  • YGR130C
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
    Gene Ontology: [View List]
    Two-hybrid
    bait Newman JR (2000) [177]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRE11
  • XRS4
  • NGS1
  • RAD58
  • YMR224C
    		•  The BioGRID Database Seperator Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSE1
  • YML049C
    		•  The BioGRID Database Seperator Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOC2
  • YOR206W
    		•  The BioGRID Database Seperator Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA135
  • RPA2
  • RRN2
  • SRP3
  • YPR010C
    		•  The BioGRID Database Seperator RNA polymerase I subunit A135
    Gene Ontology: [View List]
    Two-hybrid
    hit Cho RJ (1998) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIP4
  • YJL089W
    		•  The BioGRID Database Seperator C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URM1
  • YIL008W
    		•  The BioGRID Database Seperator Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AIM22
  • YJL046W
    		•  The BioGRID Database Seperator Putative lipoate-protein ligase A family member; null mutant displays respiratory growth defect, decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJR039W
  • YJR039W
    		•  The BioGRID Database Seperator Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YIL057C
  • YIL057C
    		•  The BioGRID Database Seperator Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MNR2
  • YKL064W
    		•  The BioGRID Database Seperator Putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FMP46
  • YKR049C
    		•  The BioGRID Database Seperator Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAD3
  • YJL013C
    		•  The BioGRID Database Seperator Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAD2
  • YJL030W
    		•  The BioGRID Database Seperator Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GGA1
  • YDR358W
    		•  The BioGRID Database Seperator Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CEM1
  • YER061C
    		•  The BioGRID Database Seperator Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS72
  • SWC2
  • YDR485C
    		•  The BioGRID Database Seperator Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIS2
  • HAL3
  • YKR072C
    		•  The BioGRID Database Seperator Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWR1
  • YDR334W
    		•  The BioGRID Database Seperator Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS24A
  • RPS24EA
  • YER074W
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD4
  • YER162C
    		•  The BioGRID Database Seperator Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MUP1
  • YGR055W
    		•  The BioGRID Database Seperator High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSH4
  • YFL003C
    		•  The BioGRID Database Seperator Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WWM1
  • YFL010C
    		•  The BioGRID Database Seperator WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHO2
  • PEM1
  • YGR157W
    		•  The BioGRID Database Seperator Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NTG2
  • SCR2
  • YOL043C
    		•  The BioGRID Database Seperator DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRN1
  • YPL184C
    		•  The BioGRID Database Seperator Putative RNA binding protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NEW1
  • YPL226W
    		•  The BioGRID Database Seperator ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIN2
  • YPL241C
    		•  The BioGRID Database Seperator Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM10
  • YOR068C
    		•  The BioGRID Database Seperator Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT10
  • YPL183C
    		•  The BioGRID Database Seperator Cytoplasmic protein of unknown function, plays a role in restricting Ty1 transposition
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG5
  • APG5
  • YPL149W
    		•  The BioGRID Database Seperator Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA1
  • H2A1
  • SPT11
  • YDR225W
    		•  The BioGRID Database Seperator One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
    Gene Ontology: [View List]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ISR1
  • YPR106W
    		•  The BioGRID Database Seperator Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPL039W
  • YPL039W
    		•  The BioGRID Database Seperator Putative protein of unknown function; YPL039W is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRD1
  • DER3
  • YOL013C
    		•  The BioGRID Database Seperator Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSN1
  • FUP1
  • HRB382
  • MSS10
  • YOL116W
    		•  The BioGRID Database Seperator Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS71
  • SWC6
  • YML041C
    		•  The BioGRID Database Seperator Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YML108W
  • YML108W
    		•  The BioGRID Database Seperator Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC73
  • YLR418C
    		•  The BioGRID Database Seperator Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZRC1
  • OSR1
  • YMR243C
    		•  The BioGRID Database Seperator Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCS2
  • YNL119W
    		•  The BioGRID Database Seperator Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRM11
  • YOL124C
    		•  The BioGRID Database Seperator Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG3
  • AUT1
  • APG3
  • YNR007C
    		•  The BioGRID Database Seperator E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNL115C
  • YNL115C
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALT1
  • YLR089C
    		•  The BioGRID Database Seperator Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRA2
  • CCS1
  • GLC4
  • YOL081W
    		•  The BioGRID Database Seperator GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM4
  • PFD2
  • YEL003W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTF1
  • CSL3
  • YGL244W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF3
  • CHL3
  • YLR381W
    		•  The BioGRID Database Seperator Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIM1
  • YEB1
  • YER016W
    		•  The BioGRID Database Seperator Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LEO1
  • YOR123C
    		•  The BioGRID Database Seperator Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPZ1
  • YML016C
    		•  The BioGRID Database Seperator Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDE2
  • SRA5
  • YOR360C
    		•  The BioGRID Database Seperator High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LGE1
  • YPL055C
    		•  The BioGRID Database Seperator Protein of unknown function; null mutant forms abnormally large cells
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM3
  • PFD4
  • YNL153C
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTK2
  • YJL006C
    		•  The BioGRID Database Seperator Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF19
  • MCM18
  • YPL018W
    		•  The BioGRID Database Seperator Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APQ12
  • YIL040W
    		•  The BioGRID Database Seperator Protein involved in nucleocytoplasmic transport of mRNA
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAF9
  • YNL107W
    		•  The BioGRID Database Seperator Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Le Masson I (2003) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SST2
  • YLR452C
    		•  The BioGRID Database Seperator GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHL4
  • MCM17
  • CTF17
  • YDR254W
    		•  The BioGRID Database Seperator Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM7
  • YNL147W
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IML3
  • MCM19
  • YBR107C
    		•  The BioGRID Database Seperator Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HCM1
  • YCR065W
    		•  The BioGRID Database Seperator Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT106
  • YNL206C
    		•  The BioGRID Database Seperator Protein with a role in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUB1
  • TSP1
  • YMR039C
    		•  The BioGRID Database Seperator Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC5
  • AOR1
  • YBR231C
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCS60
  • FAT2
  • YBR222C
    		•  The BioGRID Database Seperator Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM1
  • SRO1
  • YBR200W
    		•  The BioGRID Database Seperator Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FMT1
  • YBL013W
    		•  The BioGRID Database Seperator Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YBR235W
  • YBR235W
    		•  The BioGRID Database Seperator Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FEN1
  • GNS1
  • ELO2
  • VBM2
  • YCR034W
    		•  The BioGRID Database Seperator Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NBP2
  • YDR162C
    		•  The BioGRID Database Seperator Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR1
  • CPH1
  • CYP1
  • YDR155C
    		•  The BioGRID Database Seperator Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO2
  • BAS2
  • GRF10
  • YDL106C
    		•  The BioGRID Database Seperator Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL19B
  • YBL027W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC3
  • SWC1
  • YAL011W
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF4
  • CHL15
  • POB1
  • YPR135W
    		•  The BioGRID Database Seperator Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF8
  • YHR191C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOP3
  • EDR1
  • YLR234W
    		•  The BioGRID Database Seperator DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAR3
  • OSR11
  • YPR141C
    		•  The BioGRID Database Seperator Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO80
  • VAC5
  • AGS3
  • TUP7
  • YOL001W
    		•  The BioGRID Database Seperator Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIK1
  • ARM5
  • PAC14
  • YCL029C
    		•  The BioGRID Database Seperator Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Ma L (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STU2
  • YLR045C
    		•  The BioGRID Database Seperator Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Ma L (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFP1
  • VMA1
  • CLS8
  • YDL185W
    		•  The BioGRID Database Seperator Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Montpetit B (2005) [49]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UME6
  • NIM2
  • CAR80
  • RIM16
  • YDR207C
    		•  The BioGRID Database Seperator Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.