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BioGRID | Network Layout for RNA14 for Saccharomyces cerevisiae
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RNA14

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YMR061W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex|Rna14p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 7 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RNA14

RNA14 was identified with 86 protein interactions and 18 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 RNA15
  • YGL044C
    		•  The BioGRID Database Seperator Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p|Rna15p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait Dichtl B (2002)
    bait Kim M (2004)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Dheur S (2005)
    bait Collins SR (2007)
    Affinity Capture-Western
    bait Kessler MM (1996)
    hit Gross S (2001)
    hit Legrand P (2007)
    Two-hybrid
    hit Kessler MM (1997)
    bait/hit Amrani N (1997)
    bait/hit Amrani N (1997)
    Co-fractionation
    hit Noble CG (2004)
    Dosage Rescue
    bait/hit Minvielle-Sebastia L (1991)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCF11
  • YDR228C
    		•  The BioGRID Database Seperator Pcf11p|mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait Kim M (2004)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Two-hybrid
    bait Uetz P (2000)
    bait Amrani N (1997)
    bait/hit Amrani N (1997)
    Affinity Capture-Western
    bait Gross S (2001)
    bait Gross S (2001)
    Synthetic Lethality
    bait Minvielle-Sebastia L (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CFT1
  • YHH1
  • YDR301W
    		•  The BioGRID Database Seperator Cft1p|RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Reconstituted Complex
    bait Kyburz A (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO21
  • RPB1
  • RPB220
  • SUA8
  • YDL140C
    		•  The BioGRID Database Seperator RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime|Rpo21p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Sadowski M (2003)
    Two-hybrid
    bait Sadowski M (2003)
    Affinity Capture-Western
    bait Barilla D (2001)
    hit Runner VM (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTA1
  • FUN39
  • YAL043C
    		•  The BioGRID Database Seperator Pta1p|Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait Nedea E (2003)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIP1
  • YJR093C
    		•  The BioGRID Database Seperator Fip1p|Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    bait Preker PJ (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PFS2
  • YNL317W
    		•  The BioGRID Database Seperator Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex|Pfs2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    Reconstituted Complex
    bait Ohnacker M (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTI1
  • YGR156W
    		•  The BioGRID Database Seperator Pta1p Interacting protein|Pti1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Skaar DA (2002)
    Far Western
    hit Skaar DA (2002)
    Affinity Capture-MS
    bait Collins SR (2007)
    Synthetic Lethality
    bait Skaar DA (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAP1
  • YKR002W
    		•  The BioGRID Database Seperator Pap1p|Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Synthetic Lethality
    bait Minvielle-Sebastia L (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YSH1
  • BRR5
  • YLR277C
    		•  The BioGRID Database Seperator Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs|Ysh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REF2
  • YDR195W
    		•  The BioGRID Database Seperator RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes|Ref2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Nedea E (2003)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLP1
  • YOR250C
    		•  The BioGRID Database Seperator Clp1p|Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CFT2
  • YDH1
  • YLR115W
    		•  The BioGRID Database Seperator Cft2p|Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPE1
  • YKL059C
    		•  The BioGRID Database Seperator Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif|Mpe1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID24
  • GID4
  • YBR105C
    		•  The BioGRID Database Seperator Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase|Vid24p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL6B
  • YLR448W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA|Rpl6bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HCA4
  • DBP4
  • ECM24
  • YJL033W
    		•  The BioGRID Database Seperator Hca4p|Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD2
  • CPS35
  • SAF37
  • YKL018W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination|Swd2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA1
  • H2A1
  • SPT11
  • YDR225W
    		•  The BioGRID Database Seperator Hta1p|One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRP1
  • NAB4
  • NAB5
  • YOL123W
    		•  The BioGRID Database Seperator Hrp1p|Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Kessler MM (1997)
    Synthetic Lethality
    bait Kessler MM (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Act1p|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    Synthetic Lethality
    bait Davierwala AP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSM4
  • DOA10
  • KIS3
  • YIL030C
    		•  The BioGRID Database Seperator Ssm4p|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Mandart E (1995)
    hit Mandart E (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF2
  • YNL030W
    		•  The BioGRID Database Seperator Hhf2p|One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS11A
  • YDR025W
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins|Rps11ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF6
  • TAF60
  • YGL112C
    		•  The BioGRID Database Seperator Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4|Taf6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL13A
  • YDL082W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein|Rpl13ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS24B
  • RPS24EB
  • YIL069C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein|Rps24bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT5
  • YML010W
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing|Spt5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lindstrom DL (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRM1
  • KAP124
  • XPO1
  • YGR218W
    		•  The BioGRID Database Seperator Crm1p|Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Hammell CM (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNA14
  • YMR061W
    		•  The BioGRID Database Seperator Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex|Rna14p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Amrani N (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFC4
  • PCF1
  • YGR047C
    		•  The BioGRID Database Seperator One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102|Tfc4p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Gross S (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IMD4
  • YML056C
    		•  The BioGRID Database Seperator Imd4p|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed; ncRNA
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IMD2
  • PUR5
  • YHR216W
    		•  The BioGRID Database Seperator Imd2p|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRP6
  • YOR001W
    		•  The BioGRID Database Seperator Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus|Rrp6p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Canavan R (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO80
  • AGS3
  • TUP7
  • VAC5
  • YOL001W
    		•  The BioGRID Database Seperator Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance|Pho80p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Holbein S (2008)