| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
|
| SLM3 |
MTU1MTO2YDL033C |
|
tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
|
|
|
|
|
| NOP7 |
YPH1YGR103W |
|
Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G0 and the initiation of cell proliferation
|
|
|
|
|
| PDS5 |
YMR076C |
|
Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes in an interdependent manner, may function as a protein-protein interaction scaffold
|
|
|
|
|
| PDS1 |
YDR113C |
|
Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei
|
|
|
|
|
| RPS4B |
YHR203C |
|
Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
|
|
|
|
|
| AIM21 |
YIR003W |
|
Protein of unknown function; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
|
|
|
|
|
| AIM18 |
YHR198C |
|
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
|
|
|
|
|
| NOT3 |
YIL038C |
|
Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
|
|
|
|
|
| RMD11 |
YHL023C |
|
Protein required for sporulation
|
|
|
|
|
| RIM101 |
RIM1YHL027W |
|
Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC
|
|
|
|
|
| PEX2 |
PAS5CRT1YJL210W |
|
RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
|
|
|
|
|
| NEM1 |
YHR004C |
|
Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation
|
|
|
|
|
| AIM24 |
YJR080C |
|
Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media
|
|
|
|
|
| CBT1 |
SOC1YKL208W |
|
Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
|
|
|
|
|
| HAP4 |
YKL109W |
|
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
|
|
|
|
|
| IXR1 |
ORD1YKL032C |
|
Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
|
|
|
|
|
| JHD2 |
KDM5YJR119C |
|
JmjC domain family histone demethylase specific for H3-K4 (lysine at position 4 of the histone H3 protein); removes methyl groups specifically added by Set1p methyltransferase
|
|
|
|
|
| IME1 |
YJR094C |
|
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
|
|
|
|
|
| YJR079W |
YJR079W |
|
Putative protein of unknown function; mutation results in impaired mitochondrial respiration
|
|
|
|
|
| MVB12 |
YGR206W |
|
ESCRT-I subunit necessary for the efficient transport of cargo proteins to the vacuolar lumen; deletion mutant sensitive to rapamycin and nystatin; green fluorescent protein (GFP)-fusion protein localizes to endosome
|
|
|
|
|
| PTK2 |
STK2YJR059W |
|
Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
|
|
|
|
|
| PEX8 |
PAS6YGR077C |
|
Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p
|
|
|
|
|
| CHD1 |
YER164W |
|
Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes
|
|
|
|
|
| RPO41 |
YFL036W |
|
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
|
|
|
|
|
| HSP12 |
GLP1HOR5YFL014W |
|
Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
|
|
|
|
|
| RPS26B |
YER131W |
|
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
|
|
|
|
|
| SAK1 |
PAK1YER129W |
|
Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
|
|
|
|
|
| RPS17B |
RP51BRPL51BYDR447C |
|
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
|
|
|
|
|
| YER078C |
YER078C |
|
Metallopeptidase, localized to the mitochondrial matrix
|
|
|
|
|
| RPL2A |
RPL5BYFR031C-A |
|
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
|
|
|
|
|
| YGL235W |
YGL235W |
|
Putative protein of unknown function; potential Cdc28p substrate
|
|
|
|
|
| DBP7 |
YKR024C |
|
Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
|
|
|
|
|
| MRP13 |
YGR084C |
|
Mitochondrial ribosomal protein of the small subunit
|
|
|
|
|
| RIM8 |
PAL3YGL046WYGL045W |
|
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
|
|
|
|
|
| MMS2 |
YGL087C |
|
Protein involved in error-free postreplication DNA repair; forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p
|
|
|
|
|
| MON1 |
AUT12YGL124C |
|
Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate
|
|
|
|
|
| SNF4 |
CAT3SCI1YGL115W |
|
Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis
|
|
|
|
|
| PCP1 |
MDM37RBD1YGR101W |
|
Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
|
|
|
|
|
| SRN2 |
VPS37SRN10YLR119W |
|
Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
|
|
|
|
|
| IDH2 |
YOR136W |
|
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
|
|
|
|
|
| LIP5 |
YOR196C |
|
Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
|
|
|
|
|
| ATP11 |
YNL315C |
|
Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
|
|
|
|
|
| YOR131C |
YOR131C |
|
Putative protein of unknown function; non-essential gene
|
|
|
|
|
| CYT1 |
CTC1YOR29-16YOR065W |
|
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
|
|
|
|
|
| PET127 |
YOR017W |
|
Protein with a role in mitochondrial RNA stability and/or processing, located in the mitochondrial membrane
|
|
|
|
|
| CYC2 |
YOR037W |
|
Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
|
|
|
|
|
| MCK1 |
YPK1YNL307C |
|
Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
|
|
|
|
|
| SIN4 |
GAL22SDI3RYE1YNL236W |
|
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
|
|
|
|
|
| GLR1 |
LPG17YPL091W |
|
Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione
|
|
|
|
|
| JID1 |
YPR061C |
|
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
|
|
|
|
|
| HPA2 |
YPR193C |
|
Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
|
|
|
|
|
| HRR25 |
YPL204W |
|
Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
|
|
|
|
|
| NEW1 |
YPL226W |
|
ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein
|
|
|
|
|
| TPO4 |
YOR273C |
|
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
|
|
|
|
|
| PDE2 |
SRA5YOR360C |
|
High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
|
|
|
|
|
| MDM38 |
MKH1YOL027C |
|
Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
|
|
|
|
|
| SPE2 |
YOL052C |
|
S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
|
|
|
|
|
| PDR8 |
YLR266C |
|
Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
|
|
|
|
|
| YLR290C |
YLR290C |
|
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
|
|
|
|
|
| COX8 |
YLR395C |
|
Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
|
|
|
|
|
| PEX13 |
PAS20YLR191W |
|
Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
|
|
|
|
|
| SAM1 |
ETH10YLR180W |
|
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
|
|
|
|
|
| BAS1 |
YKR099W |
|
Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
|
|
|
|
|
| RVS167 |
YDR388W |
|
Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin
|
|
|
|
|
| ATP18 |
YML081C-A |
|
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
|
|
|
|
|
| SIP5 |
YMR140W |
|
Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase
|
|
|
|
|
| TOM7 |
MOM7YOK22YNL070W |
|
Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
|
|
|
|
|
| VPS27 |
GRD11VPL23VPT27YNR006W |
|
Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
|
|
|
|
|
| IRA2 |
CCS1GLC4YOL081W |
|
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
|
|
|
|
|
| LAT1 |
PDA2ODP2YNL071W |
|
Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
|
|
|
|
|
| PHO23 |
YNL097C |
|
Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)
|
|
|
|
|
| YMR244C-A |
YMR244C-A |
|
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene
|
|
|
|
|
| YAF9 |
YNL107W |
|
Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
|
|
|
|
|
| PAM17 |
FMP18YKR065C |
|
Presequence translocase-associated motor subunit, required for stable complex formation between cochaperones Pam16p and Pam18p, promotes association of Pam16p-Pam18p with the presequence translocase
|
|
|
|
|
| EAF1 |
VID21YDR359C |
|
Component of the NuA4 histone acetyltransferase complex
|
|
|
|
|
| VTC1 |
PHM4NRF1YER072W |
|
Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase
|
|
|
|
|
| DEG1 |
PUS3YFL001W |
|
Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm
|
|
|
|
|
| FAR7 |
YFR008W |
|
Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p
|
|
|
|
|
| CEM1 |
YER061C |
|
Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
|
|
|
|
|
| YPT31 |
YPT8YER031C |
|
GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
|
|
|
|
|
| YDR514C |
YDR514C |
|
Putative protein of unknown function
|
|
|
|
|
| PAU10 |
YDR542W |
|
Pau10p
|
|
|
|
|
| UBP6 |
YFR010W |
|
Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds
|
|
|
|
|
| HAP2 |
YGL237C |
|
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
|
|
|
|
|
| UBR1 |
PTR1YGR184C |
|
Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome
|
|
|
|
|
| SOL4 |
YGR248W |
|
6-phosphogluconolactonase with similarity to Sol3p
|
|
|
|
|
| SRB2 |
HRS2MED20YHR041C |
|
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
|
|
|
|
|
| RTS3 |
YGR161C |
|
Putative component of the protein phosphatase type 2A complex
|
|
|
|
|
| YGR021W |
YGR021W |
|
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
|
|
|
|
|
| MTO1 |
IPS1YGL236C |
|
Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
|
|
|
|
|
| POX1 |
FOX1YGL205W |
|
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
|
|
|
|
|
| IPK1 |
GSL1YDR315C |
|
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
|
|
|
|
|
| PMP3 |
SNA1YDR276C |
|
Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
|
|
|
|
|
| EDE1 |
BUD15YBL047C |
|
Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
|
|
|
|
|
| SLA1 |
YBL007C |
|
Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
|
|
|
|
|
| SCO2 |
YBR024W |
|
Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
|
|
|
|
|
| VPS8 |
VPT8FUN15YAL002W |
|
Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif
|
|
|
|
|
| MEP2 |
YNL142W |
|
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
|
|
|
|
|
| FLO8 |
YER108CPHD5YER109C |
|
Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
|
|
|
|
|
| MEP1 |
AMT1YGR121C |
|
Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
|
|
|
|
|
| SUS1 |
YBR111W-A |
|
Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex
|
|
|
|
|
| RPS6B |
RPS102RPS101LPG18YBR181C |
|
Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
|
|
|
|
|
| VPS41 |
VAM2CVT8SVL2YDR080W |
|
Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
|
|
|
|
|
| KGD2 |
YDR148C |
|
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
|
|
|
|
|
| MFB1 |
YDR219C |
|
Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
|
|
|
|
|
| TFP1 |
VMA1CLS8YDL185W |
|
Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
|
|
|
|
|
| MGR1 |
YCL044C |
|
Subunit, with Yme1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; required for growth of cells lacking the mitochondrial genome
|
|
|
|
|
| DER1 |
YBR201W |
|
Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
|
|
|
|
|
| MCX1 |
YBR227C |
|
Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins
|
|
|
|
|
| COX23 |
YHR116W |
|
Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p
|
|
|
|
|
| YSP1 |
YHR155W |
|
Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone
|
|
|
|
|
| ACK1 |
YDL203C |
|
Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
|
|
|
|
|
| MGT1 |
YDL200C |
|
DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
|
|
|
|
|
| YDL157C |
YDL157C |
|
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
|
|
|
|
|
| BPH1 |
YCR032W |
|
PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
|
|
|
|
|
| RPS14A |
RPL59CRY1YCR031C |
|
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
|
|
|
|
|
| SGF29 |
YCL010C |
|
SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex
|
|
|
|
|
| SAT4 |
HAL4YCR008W |
|
Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
|
|
|
|
|
| QRI7 |
YDL104C |
|
Putative metalloprotease, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
|
|
|
|
|
| RPS16B |
YDL083C |
|
Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
|
|
|
|
|
| PPH3 |
YDR075W |
|
Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
|
|
|
|
|
| CPR1 |
CPH1CYP1YDR155C |
|
Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
|
|
|
|
|
| LSM6 |
YDR378C |
|
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
|
|
|
|
|
| YDR018C |
YDR018C |
|
Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
|
|
|
|
|
| PEX19 |
PAS12YDL065C |
|
Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane
|
|
|
|
|
| THI3 |
KID1YDL080C |
|
Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
|
|
|
|
|
| RXT3 |
YDL076C |
|
Subunit of the RPD3L complex; involved in histone deacetylation
|
|
|
|
|
| SWC5 |
AOR1YBR231C |
|
Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
|
|
|
|
|
| PDB1 |
YBR221C |
|
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
|
|
|
|
|
| VPS13 |
SOI1VPT2YLL040C |
|
Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention
|
|
|
|
|
| PUS5 |
YLR165C |
|
Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
|
|
|
|
|
| YPT6 |
YLR262C |
|
GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
|
|
|
|
|
| DID4 |
VPT14VPS2REN1YKL002W |
|
Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
|
|
|
|
|
| DOA1 |
UFD3ZZZ4YKL213C |
|
WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
|
|
|
|
|
| VID28 |
GID5YIL017WYIL017C |
|
Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
|
|
|
|
|
| GSH1 |
YJL101C |
|
Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury
|
|
|
|
|
| EXG1 |
BGL1YLR300W |
|
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
|
|
|
|
|
| MSC1 |
YML128C |
|
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
|
|
|
|
|
| MBA1 |
YBR185C |
|
Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane
|
|
|
|
|
| MSI1 |
CAC3YBR195C |
|
Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46
|
|
|
|
|
| RXT2 |
RAF60YBR095C |
|
Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
|
|
|
|
|
| PIN4 |
MDT1YBL051C |
|
Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
|
|
|
|
|
| YAL065C |
YAL065C |
|
Putative protein of unknown function; has homology to FLO1; possible pseudogene
|
|
|
|
|
| GDH3 |
FUN51YAL062W |
|
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
|
|
|
|
|
| NKP1 |
YDR383C |
|
Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
|
|
|
|
|
