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BioGRID | Network Layout for QRI8 for Saccharomyces cerevisiae
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QRI8

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: UBC7, YMR022W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with QRI8

QRI8 was identified with 14 protein interactions and 77 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 UBC6
  • DOA2
  • YER100W
    		•  The BioGRID Database Seperator Ubc6p|Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Wang Q (2003)
    bait Bordallo J (1998)
    bait Gilon T (1998)
    bait Hiller MM (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSP5
  • MDP1
  • MUT2
  • NPI1
  • YER125W
    		•  The BioGRID Database Seperator Rsp5p|Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Arnason TG (2005)
    Dosage Growth Defect
    bait Arnason TG (2005)
    Phenotypic Enhancement
    bait Arnason TG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CUE1
  • KIS4
  • YMR264W
    		•  The BioGRID Database Seperator Cue1p|Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait Biederer T (1997)
    Affinity Capture-Western
    bait Ravid T (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMG2
  • YLR450W
    		•  The BioGRID Database Seperator Hmg2p|One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Gardner RG (2001)
    Biochemical Activity
    hit Flury I (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC34
  • DNA6
  • UBC3
  • YDR054C
    		•  The BioGRID Database Seperator Cdc34p|Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Arnason TG (2005)
    Dosage Rescue
    bait Arnason TG (2005)
    Phenotypic Enhancement
    bait Arnason TG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSK1
  • YLR006C
    		•  The BioGRID Database Seperator Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate|Ssk1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    Dosage Lethality
    hit Sato N (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRE1
  • ERN1
  • YHR079C
    		•  The BioGRID Database Seperator Ire1p|Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Friedlander R (2000)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAC1
  • ERN4
  • IRE15
  • YFL031W
    		•  The BioGRID Database Seperator Hac1p|bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Friedlander R (2000)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL4
  • HRD4
  • YBR170C
    		•  The BioGRID Database Seperator Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation|Npl4p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Hitchcock AL (2003)
    bait Auld KL (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG6
  • ISE1
  • LIS1
  • SED6
  • YML008C
    		•  The BioGRID Database Seperator Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane|Erg6p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC28
  • ANU2
  • YIL076W
    		•  The BioGRID Database Seperator Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth|Sec28p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM4
  • PFD2
  • YEL003W
    		•  The BioGRID Database Seperator Gim4p|Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIC1
  • YLR039C
    		•  The BioGRID Database Seperator Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes|Ric1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Schuldiner M (2005)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APC5
  • RMC1
  • YOR249C
    		•  The BioGRID Database Seperator Apc5p|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Arnason TG (2005)
    Dosage Growth Defect
    bait Arnason TG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSM4
  • DOA10
  • KIS3
  • YIL030C
    		•  The BioGRID Database Seperator Ssm4p|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Carvalho P (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubi4p|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRD1
  • DER3
  • YOL013C
    		•  The BioGRID Database Seperator Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Deak PM (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD4
  • YKL010C
    		•  The BioGRID Database Seperator Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins|Ufd4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Ravid T (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BCY1
  • SRA1
  • YIL033C
    		•  The BioGRID Database Seperator Bcy1p|Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APOB
  • FLDB
  • EG338
    		•  The BioGRID Database Seperator apoB-100|apoB-48|apolipoprotein B|apolipoprotein B48; apolipoprotein B (including Ag(x) antigen)
    Gene Ontology: [View List]
    Biochemical Activity
    hit Hrizo SL (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSK2
  • YNR031C
    		•  The BioGRID Database Seperator MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress|Ssk2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AHP1
  • YLR109W
    		•  The BioGRID Database Seperator Ahp1p|Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6|Ypt6p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF9
  • TAF17
  • YMR236W
    		•  The BioGRID Database Seperator Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3|Taf9p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET18
  • MMS19
  • YIL128W
    		•  The BioGRID Database Seperator DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance|Met18p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERV46
  • FUN9
  • YAL042W
    		•  The BioGRID Database Seperator Erv46p|Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMG1
  • YML075C
    		•  The BioGRID Database Seperator Hmg1p|One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae; protein coding
    Gene Ontology: [View List]
    Dosage Lethality
    hit Loertscher J (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RGP1
  • YDR137W
    		•  The BioGRID Database Seperator Rgp1p|Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA1
  • UFD3
  • ZZZ4
  • YKL213C
    		•  The BioGRID Database Seperator Doa1p|WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM5
  • PFD5
  • YML094W
    		•  The BioGRID Database Seperator Gim5p|Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF7
  • TAF67
  • YMR227C
    		•  The BioGRID Database Seperator TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation|Taf7p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PFD1
  • GIM6
  • YJL179W
    		•  The BioGRID Database Seperator Pfd1p|Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS8
  • FUN15
  • VPT8
  • YAL002W
    		•  The BioGRID Database Seperator Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif|Vps8p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHR3
  • APF1
  • YDL212W
    		•  The BioGRID Database Seperator Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface|Shr3p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Kota J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WBP1
  • YEL002C
    		•  The BioGRID Database Seperator Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum|Wbp1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP6
  • YFR010W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds|Ubp6p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Crosas B (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LTE1
  • MSI2
  • YAL024C
    		•  The BioGRID Database Seperator Lte1p|Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Ye P (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID21
  • EAF1
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex|Eaf1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Mitchell L (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HFI1
  • ADA1
  • SRM12
  • SUP110
  • YPL254W
    		•  The BioGRID Database Seperator Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions|Hfi1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX8
  • YER116C
    		•  The BioGRID Database Seperator Slx8p|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIK1
  • YMR198W
    		•  The BioGRID Database Seperator Cik1p|Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p; protein coding
    Gene Ontology: [View List]