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BioGRID | Network Layout for POB3 for Saccharomyces cerevisiae
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POB3

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YML069W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Pob3p|Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p); protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 10 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with POB3

POB3 was identified with 93 protein interactions and 49 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SPT16
  • CDC68
  • SSF1
  • YGL207W
    		•  The BioGRID Database Seperator Spt16p|Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait Gavin AC (2002)
    bait Lindstrom DL (2003)
    bait/hit Krogan NJ (2002)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    bait Brewster NK (2001)
    bait/hit Wittmeyer J (1997)
    hit O'Donnell AF (2004)
    Reconstituted Complex
    bait O'Donnell AF (2004)
    bait Formosa T (2001)
    Co-fractionation
    bait Brewster NK (1998)
    Synthetic Growth Defect
    bait Schlesinger MB (2000)
    Synthetic Lethality
    bait Formosa T (2001)
    hit Schlesinger MB (2000)
    bait Vandemark AP (2008)
    Phenotypic Enhancement
    hit Schlesinger MB (2000)
    Dosage Rescue
    bait Schlesinger MB (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHD1
  • YER164W
    		•  The BioGRID Database Seperator Chd1p|Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Krogan NJ (2002)
    hit Krogan NJ (2006)
    Affinity Capture-Western
    bait Simic R (2003)
    Synthetic Rescue
    hit Costa PJ (2000)
    hit Biswas D (2007)
    hit Biswas D (2008)
    Phenotypic Suppression
    hit Biswas D (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LEO1
  • YOR123C
    		•  The BioGRID Database Seperator Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation|Leo1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Krogan NJ (2002)
    bait Squazzo SL (2002)
    hit Krogan NJ (2006)
    hit Collins SR (2007)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKA1
  • YIL035C
    		•  The BioGRID Database Seperator Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases|Cka1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait Ho Y (2002)
    bait Krogan NJ (2006)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAF1
  • YBR279W
    		•  The BioGRID Database Seperator Paf1p|RNAP II-associated protein; defines large complex biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme; required for full expression of a subset of cell cycle-regulated genes; homolog of human PD2/hPAF1; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Krogan NJ (2002)
    bait Squazzo SL (2002)
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTF1
  • CSL3
  • YGL244W
    		•  The BioGRID Database Seperator Rtf1p|Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Krogan NJ (2002)
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    Synthetic Lethality
    bait Costa PJ (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKA2
  • YOR29-12
  • YOR061W
    		•  The BioGRID Database Seperator Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases|Cka2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKB2
  • YOR039W
    		•  The BioGRID Database Seperator Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases|Ckb2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTR9
  • CDP1
  • YOL145C
    		•  The BioGRID Database Seperator Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeats|Ctr9p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Krogan NJ (2002)
    hit Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF1
  • YBR009C
    		•  The BioGRID Database Seperator Hhf1p|One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    Dosage Lethality
    hit Formosa T (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKB1
  • YGL019W
    		•  The BioGRID Database Seperator Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases|Ckb1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT6
  • CRE2
  • SSN20
  • YGR116W
    		•  The BioGRID Database Seperator Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation|Spt6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lindstrom DL (2003)
    Co-fractionation
    hit Wittmeyer J (1999)
    Synthetic Growth Defect
    hit Wittmeyer J (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFA1
  • BUF2
  • FUN3
  • RPA1
  • YAR007C
    		•  The BioGRID Database Seperator Rfa1p|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit VanDemark AP (2006)
    Reconstituted Complex
    hit VanDemark AP (2006)
    Phenotypic Suppression
    hit VanDemark AP (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VIP1
  • YLR410W
    		•  The BioGRID Database Seperator Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1|Vip1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTB2
  • YBL002W
    		•  The BioGRID Database Seperator Htb2p|One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF2
  • YNL030W
    		•  The BioGRID Database Seperator Hhf2p|One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC73
  • YLR418C
    		•  The BioGRID Database Seperator Cdc73p|Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Krogan NJ (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSH1
  • YOL054W
    		•  The BioGRID Database Seperator Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein|Psh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SET2
  • EZL1
  • YJL168C
    		•  The BioGRID Database Seperator Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p|Set2p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Biswas D (2006)
    hit Biswas D (2008)
    Phenotypic Suppression
    hit Biswas D (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF4
  • CHL15
  • POB1
  • YPR135W
    		•  The BioGRID Database Seperator Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion|Ctf4p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Schlesinger MB (2000)
    Phenotypic Enhancement
    bait Collins SR (2007)
    hit Schlesinger MB (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPD3
  • MOF6
  • REC3
  • SDI2
  • YNL330C
    		•  The BioGRID Database Seperator Histone deacetylase; regulates transcription and silencing|Rpd3p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Formosa T (2001)
    Synthetic Lethality
    hit VanDemark AP (2006)
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT1
  • BUR5
  • SIN2
  • YBR010W
    		•  The BioGRID Database Seperator Hht1p|One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    Dosage Lethality
    hit Formosa T (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA1
  • H2A1
  • SPT11
  • YDR225W
    		•  The BioGRID Database Seperator Hta1p|One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    Synthetic Lethality
    hit Vandemark AP (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL1
  • CDC17
  • CRT5
  • HPR3
  • YNL102W
    		•  The BioGRID Database Seperator Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis|Pol1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wittmeyer J (1997)
    Phenotypic Enhancement
    hit Schlesinger MB (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NHP6A
  • YPR052C
    		•  The BioGRID Database Seperator High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters|Nhp6ap; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Brewster NK (2001)
    Synthetic Lethality
    bait Formosa T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEC1
  • ESR1
  • SAD3
  • YBR136W
    		•  The BioGRID Database Seperator Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination|Mec1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Schlesinger MB (2000)
    Phenotypic Enhancement
    hit Schlesinger MB (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HIR1
  • YBL008W
    		•  The BioGRID Database Seperator Hir1p|Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Formosa T (2002)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNA2
  • WEB2
  • YHR164C
    		•  The BioGRID Database Seperator Dna2p|Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Schlesinger MB (2000)
    Phenotypic Enhancement
    hit Schlesinger MB (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOP2
  • TOR3
  • TRF3
  • YNL088W
    		•  The BioGRID Database Seperator Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis|Top2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOP1
  • MAK1
  • MAK17
  • YOL006C
    		•  The BioGRID Database Seperator Top1p|Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YML107C
  • PML39
    		•