| Name |
Aliases |
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Description |
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| HMG2 |
YLR450W |
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Hmg2p|One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; protein coding
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| WBP1 |
YEL002C |
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Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum|Wbp1p; protein coding
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| VPS73 |
YGL104C |
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Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family|Vps73p; protein coding
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| ERG25 |
YGR060W |
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C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol|Erg25p; protein coding
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| ALG7 |
TUR1YBR243C |
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Alg7p|UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin; protein coding
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| HRD3 |
YLR207W |
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Hrd3p|Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events; protein coding
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| RPL27A |
RPL27YHR010W |
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Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein|Rpl27ap; protein coding
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| RAD51 |
MUT5YER095W |
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Rad51p|Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein; protein coding
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| TNA1 |
YGR260W |
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High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)|Tna1p; protein coding
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| HMG1 |
YML075C |
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Hmg1p|One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae; protein coding
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| HRD1 |
DER3YOL013C |
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Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
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| SUR4 |
APA1ELO3SRE1YLR372W |
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Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis|Sur4p; protein coding
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| YPL264C |
YPL264C |
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Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene|Ypl264cp; protein coding
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| NSG1 |
YHR133C |
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Nsg1p|Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; protein coding
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| SRP102 |
YKL154W |
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Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane|Srp102p; protein coding
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| SPO75 |
YLL005C |
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Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis|Spo75p; protein coding
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| SNL1 |
YIL016W |
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Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein|Snl1p; protein coding
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| YBR159W |
IFA38 |
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Ifa38p|Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides; protein coding
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| PHO88 |
YBR106W |
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Pho88p|Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations; protein coding
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| IRE1 |
ERN1YHR079C |
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Ire1p|Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; protein coding
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| RIC1 |
YLR039C |
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Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes|Ric1p; protein coding
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| QRI8 |
UBC7YMR022W |
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Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
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| SSM4 |
DOA10KIS3YIL030C |
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Ssm4p|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; protein coding
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| RGP1 |
YDR137W |
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Rgp1p|Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; protein coding
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| CUE1 |
KIS4YMR264W |
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Cue1p|Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; protein coding
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| BRE4 |
YDL231C |
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Bre4p|Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport; protein coding
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| GPT2 |
GAT1YKR067W |
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Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis|Gpt2p; protein coding
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| GSF2 |
ECM6YML048W |
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ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression|Gsf2p; protein coding
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| SPF1 |
COD1PER9PIO1YEL031W |
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P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1|Spf1p; protein coding
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| SCS7 |
FAH1YMR272C |
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Scs7p|Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth; protein coding
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| PAN1 |
DIM2MDP3MIP3YIR006C |
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Pan1p|Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease; protein coding
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