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BioGRID | Network Layout for GIM5 for Saccharomyces cerevisiae
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GIM5

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: PFD5, YML094W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Gim5p|Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with GIM5

GIM5 was identified with 18 protein interactions and 318 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 PAC10
  • GIM2
  • PFD3
  • RKS2
  • YGR078C
    		•  The BioGRID Database Seperator Pac10p|Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    hit Geissler S (1998)
    PCA
    bait Tarassov K (2008)
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKE2
  • GIM1
  • PFD6
  • YLR200W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin|Yke2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000)
    Affinity Capture-Western
    hit Geissler S (1998)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM4
  • PFD2
  • YEL003W
    		•  The BioGRID Database Seperator Gim4p|Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Geissler S (1998)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM3
  • PFD4
  • YNL153C
    		•  The BioGRID Database Seperator Gim3p|Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Geissler S (1998)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    hit Collins SR (2007)
    Phenotypic Suppression
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PFD1
  • GIM6
  • YJL179W
    		•  The BioGRID Database Seperator Pfd1p|Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIM1
  • YEB1
  • YER016W
    		•  The BioGRID Database Seperator Bim1p|Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001)
    bait/hit Tong AH (2004)
    bait Pan X (2004)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN4
  • SON1
  • UFD5
  • YDL020C
    		•  The BioGRID Database Seperator Rpn4p|Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS161
  • END6
  • FUS7
  • SPE161
  • YCR009C
    		•  The BioGRID Database Seperator Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress|Rvs161p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Friesen H (2006)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF8
  • YHR191C
    		•  The BioGRID Database Seperator Ctf8p|Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF4
  • CHL15
  • POB1
  • YPR135W
    		•  The BioGRID Database Seperator Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion|Ctf4p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWR1
  • YDR334W
    		•  The BioGRID Database Seperator Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Swr1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RBL2
  • YOR265W
    		•  The BioGRID Database Seperator Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A|Rbl2p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    Dosage Rescue
    hit Geissler S (1998)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIN8
  • KSL2
  • SDS15
  • YEL061C
    		•  The BioGRID Database Seperator Cin8p|Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    bait Pan X (2004)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF18
  • CHL12
  • YMR078C
    		•  The BioGRID Database Seperator Ctf18p|Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS72
  • SWC2
  • YDR485C
    		•  The BioGRID Database Seperator Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting|Vps72p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS71
  • SWC6
  • YML041C
    		•  The BioGRID Database Seperator Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting|Vps71p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC5
  • AOR1
  • YBR231C
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Swc5p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM16
  • YPR046W
    		•  The BioGRID Database Seperator Mcm16p|Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Measday V (2005)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC3
  • SWC1
  • YAL011W
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae|Swc3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLA4
  • ERC10
  • YNL298W
    		•  The BioGRID Database Seperator Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p|Cla4p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Goehring AS (2003)
    hit Tong AH (2004)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF19
  • MCM18
  • YPL018W
    		•  The BioGRID Database Seperator Ctf19p|Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Measday V (2005)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAD2
  • YJL030W
    		•  The BioGRID Database Seperator Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p|Mad2p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    bait Sarin S (2004)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHL4
  • CTF17
  • MCM17
  • YDR254W
    		•  The BioGRID Database Seperator Chl4p|Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Measday V (2005)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCC1
  • YCL016C
    		•  The BioGRID Database Seperator Dcc1p|Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUB4
  • YLR212C
    		•  The BioGRID Database Seperator Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body|Tub4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Geissler S (1998)
    Synthetic Lethality
    hit Geissler S (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IML3
  • MCM19
  • YBR107C
    		•  The BioGRID Database Seperator Iml3p|Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Measday V (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD53
  • LSD1
  • MEC2
  • SPK1
  • YPL153C
    		•  The BioGRID Database Seperator Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication|Rad53p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUB2
  • PAC7
  • YMR055C
    		•  The BioGRID Database Seperator Bub2p|Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling|Bmh1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    hit Collins SR (2007)