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BioGRID | Network Layout for RAD10 for Saccharomyces cerevisiae
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RAD10

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YML095C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 10 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RAD10

RAD10 was identified with 35 protein interactions and 54 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 RAD1
  • LPB9
  • YPL022W
    		•  The BioGRID Database Seperator Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    bait/hit Guzder SN (1996) [11]
    bait/hit Bardwell L (1992) [2]
    bait/hit Bailly V (1992) [2]
    bait Flott S (2007) [7]
    Reconstituted Complex
    bait Tomkinson AE (1993) [1]
    bait Tomkinson AE (1994) [1]
    bait Sung P (1993) [1]
    bait Rodriguez K (1996) [1]
    Two-hybrid
    bait Bardwell AJ (1993) [1]
    bait Yu H (2008) [1778]
    Co-fractionation
    bait Guzder SN (1996) [11]
    Dosage Rescue
    bait Siede W (1993) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSH2
  • PMS5
  • YOL090W
    		•  The BioGRID Database Seperator Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Bertrand P (1998) [18]
    Two-hybrid
    bait/hit Bertrand P (1998) [18]
    Phenotypic Enhancement
    bait Saparbaev M (1996) [11]
    hit Bertrand P (1998) [18]
    Synthetic Rescue
    hit Bertrand P (1998) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAW1
  • YAL027W
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD18
  • YCR066W
    		•  The BioGRID Database Seperator Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Hwang JY (2005) [26]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Dixon SJ (2008) [1412]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APN1
  • YKL114C
    		•  The BioGRID Database Seperator Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Xiao W (1998) [4]
    Phenotypic Enhancement
    bait Guzder SN (2004) [4]
    Negative Genetic
    hit Collins SR (2007) [14430]
    Synthetic Lethality
    hit Ragu S (2007) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD14
  • YMR201C
    		•  The BioGRID Database Seperator Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Guzder SN (1996) [11]
    bait Rodriguez K (1998) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD52
  • YML032C
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schiestl RH (1990) [1]
    hit Hwang JY (2005) [26]
    bait Chen CC (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM4
  • PFD2
  • YEL003W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Synthetic Growth Defect
    hit Dixon SJ (2008) [1412]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEC1
  • ESR1
  • SAD3
  • YBR136W
    		•  The BioGRID Database Seperator Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Hwang JY (2005) [26]
    Synthetic Lethality
    bait Hwang JY (2005) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRE11
  • XRS4
  • NGS1
  • RAD58
  • YMR224C
    		•  The BioGRID Database Seperator Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Hwang JY (2005) [26]
    Positive Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD27
  • ERC11
  • FEN1
  • RTH1
  • YKL113C
    		•  The BioGRID Database Seperator 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Hwang JY (2005) [26]
    Synthetic Growth Defect
    bait Hwang JY (2005) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFA1
  • BUF2
  • FUN3
  • RPA1
  • YAR007C
    		•  The BioGRID Database Seperator Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Chen C (1998) [3]
    hit Hwang JY (2005) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APN2
  • ETH1
  • YBL019W
    		•  The BioGRID Database Seperator Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Guzder SN (2004) [4]
    Synthetic Lethality
    hit Ragu S (2007) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCD1
  • TRA3
  • YOR260W
    		•  The BioGRID Database Seperator Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFP1
  • VMA1
  • CLS8
  • YDL185W
    		•  The BioGRID Database Seperator Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRO1
  • YDR300C
    		•  The BioGRID Database Seperator Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF2
  • YJL138C
    		•  The BioGRID Database Seperator Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOD2
  • YHR008C
    		•  The BioGRID Database Seperator Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAH1
  • YER043C
    		•  The BioGRID Database Seperator S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FUM1
  • YPL262W
    		•  The BioGRID Database Seperator Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSM1
  • YCR086W
    		•  The BioGRID Database Seperator Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNR2
  • CRT6
  • YJL026W
    		•  The BioGRID Database Seperator Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX4
  • YLR135W
    		•  The BioGRID Database Seperator Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Flott S (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR1
  • CPH1
  • CYP1
  • YDR155C
    		•  The BioGRID Database Seperator Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARC1
  • YGL105W
    		•  The BioGRID Database Seperator Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT4
  • YGR063C
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing
    Gene Ontology: [View List]
    Two-hybrid
    bait Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RML2
  • YEL050C
    		•  The BioGRID Database Seperator Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD6
  • UBC2
  • PSO8
  • YGL058W
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKU70
  • HDF1
  • NES24
  • YMR284W
    		•  The BioGRID Database Seperator Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Lee K (2007) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT2
  • EXA1
  • SIN1
  • YER161C
    		•  The BioGRID Database Seperator Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
    Gene Ontology: [View List]
    Dosage Rescue
    bait Sikdar N (2008) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGS1
  • YMR190C
    		•  The BioGRID Database Seperator Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Putnam CD (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG11
  • CYP51
  • YHR007C
    		•  The BioGRID Database Seperator Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PUB1
  • RNP1
  • YNL016W
    		•  The BioGRID Database Seperator Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP4
  • RNA4
  • YPR178W
    		•  The BioGRID Database Seperator Splicing factor, component of the U4/U6-U5 snRNP complex
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHG1
  • CPS15
  • YBR258C
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMM1
  • DUS2
  • YNR015W
    		•  The BioGRID Database Seperator Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EST1
  • YLR233C
    		•  The BioGRID Database Seperator TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     XDJ1
  • YLR090W
    		•  The BioGRID Database Seperator Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GRE3
  • YHR104W
    		•  The BioGRID Database Seperator Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
    Gene Ontology: [View List]
    Positive Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD5
  • REV2
  • SNM2
  • YLR032W
    		•  The BioGRID Database Seperator DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; contains RING finger domain
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Hwang JY (2005) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS4
  • SLX2
  • YBR100W
  • YBR098W
    		•  The BioGRID Database Seperator Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Hwang JY (2005) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIF1
  • TST1
  • YML061C
    		•  The BioGRID Database Seperator DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Hwang JY (2005) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MUS81
  • SLX3
  • YDR386W
    		•  The BioGRID Database Seperator Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Hwang JY (2005) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELG1
  • RTT110
  • YOR144C
    		•  The BioGRID Database Seperator Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Hwang JY (2005) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLA4
  • ERC10
  • YNL298W
    		•  The BioGRID Database Seperator Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Goehring AS (2003) [72]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAD2
  • YJL030W
    		•  The BioGRID Database Seperator Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Daniel JA (2006) [214]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD53
  • MEC2
  • SPK1
  • LSD1
  • YPL153C
    		•  The BioGRID Database Seperator Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VRP1
  • YLR337W
  • MDP2
  • END5
  • YLR337C
    		•  The BioGRID Database Seperator Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP18
  • YGR006W
    		•  The BioGRID Database Seperator Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIH1
  • NOP17
  • YHR034C
    		•  The BioGRID Database Seperator Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REV3
  • PSO1
  • YPL167C
    		•  The BioGRID Database Seperator Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Chen CC (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MFT1
  • MFT52
  • YML062C
    		•  The BioGRID Database Seperator Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.