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BioGRID | Network Layout for BCY1 for Saccharomyces cerevisiae
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BCY1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: SRA1, YIL033C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Bcy1p|Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 9 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with BCY1

BCY1 was identified with 52 protein interactions and 29 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 TPK2
  • PKA2
  • PKA3
  • YKR1
  • YPL203W
    		•  The BioGRID Database Seperator Tpk2p|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Ho Y (2002)
    hit Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Two-hybrid
    bait Ito T (2001)
    bait Robertson LS (1998)
    Biochemical Activity
    bait/hit Ptacek J (2005)
    Affinity Capture-Western
    bait Mandal AK (2007)
    PCA
    bait/hit Tarassov K (2008)
    Synthetic Rescue
    bait Pan X (1999)
    Dosage Rescue
    bait Nehlin JO (1992)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPK1
  • PKA1
  • SRA3
  • YJL164C
    		•  The BioGRID Database Seperator Tpk1p|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    bait Krogan NJ (2006)
    hit Collins SR (2007)
    Two-hybrid
    bait Ito T (2001)
    bait Robertson LS (1998)
    bait Peeters T (2006)
    Biochemical Activity
    bait Ptacek J (2005)
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPK3
  • YKL166C
    		•  The BioGRID Database Seperator Tpk3p|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Two-hybrid
    bait Ito T (2001)
    bait/hit Uetz P (2000)
    bait Robertson LS (1998)
    Biochemical Activity
    bait Ptacek J (2005)
    Phenotypic Enhancement
    bait Mazon MJ (1993)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAS2
  • CTN5
  • CYR3
  • GLC5
  • YNL098C
    		•  The BioGRID Database Seperator GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes|Ras2p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Uno I (1982)
    bait Toda T (1985)
    bait Lesuisse E (1991)
    bait Cannon JF (1987)
    Phenotypic Suppression
    bait Trott A (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYR1
  • CDC35
  • FIL1
  • HSR1
  • YJL005W
    		•  The BioGRID Database Seperator Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation|Cyr1p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Matsumoto K (1983)
    bait Matsumoto K (1982)
    Dosage Rescue
    bait Tripp ML (1986)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAS1
  • YOR101W
    		•  The BioGRID Database Seperator GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes|Ras1p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Toda T (1985)
    bait Cannon JF (1987)
    bait Tatchell K (1985)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO85
  • LDB15
  • YPL031C
    		•  The BioGRID Database Seperator Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5|Pho85p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    Synthetic Rescue
    bait Timblin BK (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSE1
  • LPG3
  • MSI3
  • YPL106C
    		•  The BioGRID Database Seperator ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Trott A (2005)
    hit Shirayama M (1993)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP43
  • YGL120C
    		•  The BioGRID Database Seperator Prp43p|RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     QRI8
  • UBC7
  • YMR022W
    		•  The BioGRID Database Seperator Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGK3
  • YOL128C
    		•  The BioGRID Database Seperator Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation|Ygk3p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VHS1
  • YDR247W
    		•  The BioGRID Database Seperator Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p|Vhs1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK1
  • CKI2
  • YHR135C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p|Yck1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNT1
  • YMR239C
    		•  The BioGRID Database Seperator RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end|Rnt1p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSN4
  • YKL062W
    		•  The BioGRID Database Seperator Msn4p|Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKA1
  • YIL035C
    		•  The BioGRID Database Seperator Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases|Cka1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNP1
  • YIL061C
    		•  The BioGRID Database Seperator Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein|Snp1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET18
  • MMS19
  • YIL128W
    		•  The BioGRID Database Seperator DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance|Met18p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIP41
  • YPR040W
    		•  The BioGRID Database Seperator Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway|Tip41p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PBS2
  • HOG4
  • SFS4
  • SSK4
  • YJL128C
    		•  The BioGRID Database Seperator MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress|Pbs2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOK2
  • YMR016C
    		•  The BioGRID Database Seperator Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors|Sok2p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BCY1
  • SRA1
  • YIL033C
    		•  The BioGRID Database Seperator Bcy1p|Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRZ1
  • HAL8
  • TCN1
  • YNL027W
    		•  The BioGRID Database Seperator Crz1p|Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Kafadar KA (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRO77
  • SNI2
  • SOP2
  • YBL106C
    		•  The BioGRID Database Seperator Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p|Sro77p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Drees BL (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEK1
  • MRE4
  • YOR351C
    		•  The BioGRID Database Seperator Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids|Mek1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT53
  • YNL093W
    		•  The BioGRID Database Seperator GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis|Ypt53p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZDS1
  • CES1
  • CKM1
  • NRC1
  • YMR273C
    		•  The BioGRID Database Seperator Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export|Zds1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Griffioen G (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESS1
  • PIN1
  • PTF1
  • YJR017C
    		•  The BioGRID Database Seperator Ess1p|Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKI8
  • REC103
  • YGL213C
    		•  The BioGRID Database Seperator Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses|Ski8p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTL1
  • YCR020W-B
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance|Htl1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LTE1
  • MSI2
  • YAL024C
    		•  The BioGRID Database Seperator Lte1p|Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Graumann J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO4
  • YFR034C
    		•  The BioGRID Database Seperator Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability|Pho4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Graumann J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELM1
  • LDB9
  • YKL048C
    		•  The BioGRID Database Seperator Elm1p|Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GDH3
  • FUN51
  • YAL062W
    		•  The BioGRID Database Seperator Gdh3p|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAM1
  • TEF3
  • YPL048W
    		•  The BioGRID Database Seperator Cam1p|Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS167
  • YDR388W
    		•  The BioGRID Database Seperator Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin|Rvs167p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRS6
  • MSI4
  • YOR370C
    		•  The BioGRID Database Seperator Mrs6p|Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Fujimura K (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAM1
  • YGR113W
    		•  The BioGRID Database Seperator Dam1p|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments; protein coding
    Gene Ontology: [View List]