| Name |
Aliases |
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Description |
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| COP1 |
RET1SEC33SOO1YDL145C |
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Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway|Cop1p; protein coding
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| SEC27 |
YGL137W |
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Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP|Sec27p; protein coding
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| RET2 |
YFR051C |
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Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER|Ret2p; protein coding
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| SEC21 |
YNL287W |
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Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo|Sec21p; protein coding
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| SEC26 |
YDR238C |
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Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)|Sec26p; protein coding
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| RET3 |
YPL010W |
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Ret3p|Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; protein coding
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| RIC1 |
YLR039C |
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Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes|Ric1p; protein coding
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| CDC73 |
YLR418C |
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Cdc73p|Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance; protein coding
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| SCS2 |
YER120W |
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Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog|Scs2p; protein coding
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| SEC22 |
SLY2TSL26YLR268W |
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R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog|Sec22p; protein coding
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| GCS1 |
YDL226C |
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ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p|Gcs1p; protein coding
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| HSP82 |
HSP90YPL240C |
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Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
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| COG8 |
DOR1YML071C |
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Cog8p|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; protein coding
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| YPT6 |
YLR262C |
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GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6|Ypt6p; protein coding
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| SPF1 |
COD1PER9PIO1YEL031W |
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P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1|Spf1p; protein coding
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| QRI8 |
UBC7YMR022W |
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Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
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| OPI3 |
PEM2YJR073C |
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Opi3p|Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis; protein coding
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| RGP1 |
YDR137W |
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Rgp1p|Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; protein coding
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| KEX2 |
QDS1SRB1VMA45YNL238W |
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Kex2p|Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway; protein coding
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| YDL099W |
BUG1 |
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Bug1p|Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein coding
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| GSG1 |
MUM1TRS85YDR108W |
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Gsg1p|Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication; protein coding
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| ERG3 |
PSO6SYR1YLR056W |
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C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources|Erg3p; protein coding
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| BRE5 |
YNR051C |
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Bre5p|Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A; protein coding
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| HMO1 |
HSM2YDR174W |
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Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase|Hmo1p; protein coding
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| ERV41 |
YML067C |
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Erv41p|Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein; protein coding
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| HTA2 |
H2A2YBL003C |
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Hta2p|One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; protein coding
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| SSH1 |
YBR283C |
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Ssh1p|Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential; protein coding
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| HSP60 |
CPN60MIF4YLR259C |
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Hsp60p|Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated; protein coding
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| HHF1 |
YBR009C |
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Hhf1p|One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; protein coding
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| HTB2 |
YBL002W |
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Htb2p|One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; protein coding
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| BET1 |
SLY12YIL004C |
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Bet1p|Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins; protein coding
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| POR1 |
OMP2YNL055C |
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Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated|Por1p; protein coding
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| TOP2 |
TOR3TRF3YNL088W |
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Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis|Top2p; protein coding
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| CRN1 |
YLR429W |
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Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity|Crn1p; protein coding
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| SSC1 |
ENS1YJR045C |
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Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family|Ssc1p; protein coding
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| CBK1 |
YNL161W |
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Cbk1p|Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation; protein coding
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| STM1 |
MPT4YLR150W |
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Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations|Stm1p; protein coding
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| HFI1 |
ADA1SRM12SUP110YPL254W |
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Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions|Hfi1p; protein coding
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| LEO1 |
YOR123C |
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Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation|Leo1p; protein coding
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