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BioGRID | Network Layout for TID3 for Saccharomyces cerevisiae
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TID3

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: HEC1, NDC80, YIL144W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering|Tid3p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 6 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with TID3

TID3 was identified with 87 protein interactions and 10 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SPC24
  • YMR117C
    		•  The BioGRID Database Seperator Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering|Spc24p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Nekrasov VS (2003)
    hit Janke C (2002)
    bait/hit Cheeseman IM (2002)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    Affinity Capture-Western
    hit Janke C (2001)
    bait/hit Le Masson I (2002)
    bait/hit Wigge PA (2001)
    Two-hybrid
    bait Le Masson I (2002)
    bait Cho RJ (1998)
    Reconstituted Complex
    bait Wei RR (2005)
    bait Wang HW (2008)
    Co-fractionation
    hit De Wulf P (2003)
    Dosage Rescue
    hit Janke C (2001)
    Synthetic Lethality
    hit Wigge PA (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUF2
  • YOL069W
    		•  The BioGRID Database Seperator Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering|Nuf2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001)
    hit Janke C (2001)
    bait/hit Newman JR (2000)
    hit Wong J (2007)
    Affinity Capture-MS
    hit Nekrasov VS (2003)
    hit Janke C (2002)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    Affinity Capture-Western
    hit Janke C (2001)
    bait/hit Wigge PA (2001)
    Co-fractionation
    hit De Wulf P (2003)
    Synthetic Lethality
    hit Wigge PA (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC25
  • YER018C
    		•  The BioGRID Database Seperator Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering|Spc25p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Nekrasov VS (2003)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    hit Le Masson I (2002)
    bait/hit Wigge PA (2001)
    bait Janke C (2001)
    Two-hybrid
    bait/hit Janke C (2001)
    Co-fractionation
    hit De Wulf P (2003)
    Dosage Rescue
    bait/hit Janke C (2001)
    Synthetic Lethality
    hit Wigge PA (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAM1
  • YGR113W
    		•  The BioGRID Database Seperator Dam1p|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001)
    bait/hit Shang C (2003)
    hit Wong J (2007)
    Reconstituted Complex
    bait/hit Shang C (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMC2
  • YFR031C
    		•  The BioGRID Database Seperator Component of the condensin complex, essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA, possibly in the cleft formed by the coiled-coil of the folded dimer|Smc2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Zheng L (1999)
    Two-hybrid
    hit Zheng L (1999)
    Dosage Rescue
    bait Zheng L (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MTW1
  • DSN3
  • NSL2
  • YAL034W-A
    		•  The BioGRID Database Seperator Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly|Mtw1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Nekrasov VS (2003)
    Affinity Capture-Western
    bait De Wulf P (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIN3
  • FUN52
  • NPK1
  • YAR018C
    		•  The BioGRID Database Seperator Kin3p|Nonessential protein kinase with unknown cellular role; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Chen Y (2002)
    Affinity Capture-Western
    bait Chen Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NIP100
  • PAC13
  • YPL174C
    		•  The BioGRID Database Seperator Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)|Nip100p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000)
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF19
  • MCM18
  • YPL018W
    		•  The BioGRID Database Seperator Ctf19p|Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Ohkuni K (2008)
    Synthetic Lethality
    bait Hyland KM (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIN1
  • YDR130C
    		•  The BioGRID Database Seperator Fin1p|Spindle pole body-related intermediate filament protein, forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells, able to self-assemble, expression induced during S/G2, localization cell-cycle dependent; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD1
  • YGR048W
    		•  The BioGRID Database Seperator Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol|Ufd1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADY3
  • YDL239C
    		•  The BioGRID Database Seperator Ady3p|Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR532C
  • KRE28
    		•  The BioGRID Database Seperator Protein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p|Ydr532cp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC9
  • YDL064W
    		•  The BioGRID Database Seperator SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)|Ubc9p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS1
  • RPK1
  • YDL028C
    		•  The BioGRID Database Seperator Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p|Mps1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KEL2
  • YGR238C
    		•  The BioGRID Database Seperator Kel2p|Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSE4
  • CSL2
  • YKL049C
    		•  The BioGRID Database Seperator Centromere protein that resembles histones, required for proper kinetochore function; homolog of human CENP-A|Cse4p; protein coding
    Gene Ontology: [View List]
    Co-localization
    hit Collins KA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NFI1
  • SIZ2
  • YOR156C
    		•  The BioGRID Database Seperator Nfi1p|SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC5
  • MSD2
  • PKX2
  • YMR001C
    		•  The BioGRID Database Seperator Cdc5p|Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Snead JL (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YBP2
  • YGL060W
    		•  The BioGRID Database Seperator Protein with a role in resistance to oxidative stress; has similarity to Ybp1p, which is involved in regulation of the transcription factor Yap1p via oxidation of specific cysteine residues|Ybp2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ohkuni K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NEK2
  • HsPK 21
  • HsPK21
  • NEK2A
  • EG4751
    		•  The BioGRID Database Seperator NIMA (never in mitosis gene a)-related kinase 2
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Chen Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI1
  • ADR6
  • GAM3
  • LPA1
  • YPL016W
    		•  The BioGRID Database Seperator Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2|Swi1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM6
  • YGL201C
    		•  The BioGRID Database Seperator Mcm6p|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Millson SH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JNM1
  • INS1
  • PAC3
  • YMR294W
    		•  The BioGRID Database Seperator Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B|Jnm1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NIS1
  • JIP1
  • YNL078W
    		•  The BioGRID Database Seperator Nis1p|Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPO21
  • MPC70
  • YOL091W
    		•  The BioGRID Database Seperator Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation|Spo21p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KNS1
  • YLL019C
    		•  The BioGRID Database Seperator Kns1p|Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC7
  • YNL054W
    		•  The BioGRID Database Seperator Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock|Vac7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC105
  • YGL093W
    		•  The BioGRID Database Seperator Protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; forms a complex with Ydr532cp|Spc105p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Nekrasov VS (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM21
  • CTF5
  • YDR318W
    		•  The BioGRID Database Seperator Mcm21p|Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait De Wulf P (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAD1
  • YDR016C
    		•  The BioGRID Database Seperator Dad1p|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Shang C (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CNS1
  • YBR155W
    		•  The BioGRID Database Seperator Cns1p|TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Millson SH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DSN1
  • YIR010W
    		•  The BioGRID Database Seperator Dsn1p|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Nekrasov VS (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPL260W
  • YPL260W
    		•  The BioGRID Database Seperator Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene|Ypl260wp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSB2
  • YGR014W
    		•  The BioGRID Database Seperator Msb2p|Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator