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BioGRID | Network Layout for VPH1 for Saccharomyces cerevisiae
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VPH1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YOR270C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 13 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with VPH1

VPH1 was identified with 85 protein interactions and 59 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 VMA6
  • YLR447C
    		•  The BioGRID Database Seperator Subunit D of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Mueller O (2002) [6]
    hit Kawasaki-Nishi S (2001) [18]
    hit Diepholz M (2008) [13]
    hit Ediger B (2009) [5]
    Co-fractionation
    hit Oluwatosin YE (1998) [11]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    PCA
    bait Tarassov K (2008) [2616]
    Reconstituted Complex
    bait Thaker YR (2009) [2]
    Synthetic Rescue
    hit Ediger B (2009) [5]
    Phenotypic Suppression
    hit Ediger B (2009) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFP1
  • VMA1
  • CLS8
  • YDL185W
    		•  The BioGRID Database Seperator Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Keenan Curtis K (2002) [9]
    bait Landolt-Marticorena C (2000) [6]
    hit Kawasaki-Nishi S (2001) [18]
    hit Diepholz M (2008) [13]
    hit Ediger B (2009) [5]
    Two-hybrid
    bait/hit Landolt-Marticorena C (2000) [6]
    Co-fractionation
    hit Oluwatosin YE (1998) [11]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    Positive Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA13
  • CLS11
  • YPR036W
    		•  The BioGRID Database Seperator Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Landolt-Marticorena C (2000) [6]
    hit Diab H (2009) [5]
    Affinity Capture-Western
    hit Kawasaki-Nishi S (2001) [18]
    hit Diepholz M (2008) [13]
    Co-fractionation
    hit Oluwatosin YE (1998) [11]
    PCA
    hit Tarassov K (2008) [2616]
    Two-hybrid
    bait Diab H (2009) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA7
  • YGR020C
    		•  The BioGRID Database Seperator Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Kawasaki-Nishi S (2001) [18]
    hit Diepholz M (2008) [13]
    Co-fractionation
    hit Oluwatosin YE (1998) [11]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA2
  • VAT2
  • YBR127C
    		•  The BioGRID Database Seperator Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Kawasaki-Nishi S (2001) [18]
    bait Davis-Kaplan SR (2006) [5]
    hit Hayashi K (2008) [3]
    hit Ediger B (2009) [5]
    Co-fractionation
    hit Oluwatosin YE (1998) [11]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA8
  • YEL051W
    		•  The BioGRID Database Seperator Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Kawasaki-Nishi S (2001) [18]
    hit Diepholz M (2008) [13]
    Co-fractionation
    hit Oluwatosin YE (1998) [11]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA21
  • YGR105W
    		•  The BioGRID Database Seperator Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Malkus P (2004) [6]
    Affinity Capture-Western
    bait Compton MA (2006) [5]
    bait Ryan M (2008) [8]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA4
  • YOR332W
    		•  The BioGRID Database Seperator Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Kawasaki-Nishi S (2001) [18]
    hit Hayashi K (2008) [3]
    hit Diepholz M (2008) [13]
    Co-fractionation
    hit Oluwatosin YE (1998) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA5
  • CSL5
  • VAT3
  • YKL080W
    		•  The BioGRID Database Seperator Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Kawasaki-Nishi S (2001) [18]
    hit Diepholz M (2008) [13]
    Co-fractionation
    hit Oluwatosin YE (1998) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CUP5
  • VMA3
  • CLS7
  • GEF2
  • YEL027W
    		•  The BioGRID Database Seperator Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Malkus P (2004) [6]
    hit Diepholz M (2008) [13]
    Co-fractionation
    hit Oluwatosin YE (1998) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STV1
  • YMR054W
    		•  The BioGRID Database Seperator Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Qi J (2007) [1]
    Dosage Rescue
    hit Manolson MF (1994) [1]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPH1
  • YOR270C
    		•  The BioGRID Database Seperator Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
    Gene Ontology: [View List]
    Protein-peptide
    hit Kota Z (2008) [2]
    Affinity Capture-Western
    hit Diepholz M (2008) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA10
  • YHR039C-B
  • YHR039C-A
    		•  The BioGRID Database Seperator Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Kawasaki-Nishi S (2001) [18]
    hit Diepholz M (2008) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPH2
  • CLS10
  • VMA12
  • YKL119C
    		•  The BioGRID Database Seperator Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Graham LA (1998) [3]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACS2
  • YLR153C
    		•  The BioGRID Database Seperator Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008) [2599]
    bait Takahashi H (2006) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT4
  • PCS1
  • CRL13
  • SUG2
  • YOR259C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR106C
  • YGR106C
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMC1
  • YGL006W
    		•  The BioGRID Database Seperator Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FTH1
  • YBR207W
    		•  The BioGRID Database Seperator Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFP3
  • CLS9
  • VMA11
  • YPL234C
    		•  The BioGRID Database Seperator Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Diepholz M (2008) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPA1
  • VMA16
  • YHR026W
    		•  The BioGRID Database Seperator Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Diepholz M (2008) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA9
  • LDB10
  • CWH36
  • YCL005W-A
    		•  The BioGRID Database Seperator Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Diepholz M (2008) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Atp6v1e2
  • E1
  • 4930500C1...
  • Atp6e1
    		•  The BioGRID Database Seperator ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E-like 2
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Hayashi K (2008) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CEX1
  • YOR112W
    		•  The BioGRID Database Seperator Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCE102
  • NCE2
  • YPR149W
    		•  The BioGRID Database Seperator Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA22
  • CEV1
  • VPH6
  • YHR060W
    		•  The BioGRID Database Seperator Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Graham LA (1998) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VTC4
  • YJL012C-A
  • PHM3
  • YJL012C
    		•  The BioGRID Database Seperator Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Mueller O (2002) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VTC1
  • PHM4
  • NRF1
  • YER072W
    		•  The BioGRID Database Seperator Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Mueller O (2002) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDC1
  • YLR044C
    		•  The BioGRID Database Seperator Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YOR1
  • YRS1
  • YGR281W
    		•  The BioGRID Database Seperator Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PGI1
  • CDC30
  • YBR196C
    		•  The BioGRID Database Seperator Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YRA1
  • SHE11
  • YDR381W
    		•  The BioGRID Database Seperator Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOP6
  • YDL213C
    		•  The BioGRID Database Seperator Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EMI2
  • YDR516C
    		•  The BioGRID Database Seperator Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LYS9
  • LYS13
  • YNR050C
    		•  The BioGRID Database Seperator Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRR1
  • YKL116C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPF1
  • YHR088W
    		•  The BioGRID Database Seperator Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCK1
  • JPM2
  • PPC1
  • YKR097W
    		•  The BioGRID Database Seperator Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
    Gene Ontology: [View List]
    Positive Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FRE1
  • YLR214W
    		•  The BioGRID Database Seperator Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AUR1
  • YKL004W
    		•  The BioGRID Database Seperator Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLC1
  • SCD4
  • YGR167W
    		•  The BioGRID Database Seperator Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
    Gene Ontology: [View List]
    Positive Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KSS1
  • YGR040W
    		•  The BioGRID Database Seperator Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUO1
  • YGL061C
    		•  The BioGRID Database Seperator Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAU12
  • YGR294W
    		•  The BioGRID Database Seperator Pau12p
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOG1
  • YHR044C
    		•  The BioGRID Database Seperator 2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOG2
  • YHR043C
    		•  The BioGRID Database Seperator 2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAM35
  • TOB38
  • FMP20
  • TOM38
  • YHR083W
    		•  The BioGRID Database Seperator Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIS3
  • RRP44
  • YOL021C
    		•  The BioGRID Database Seperator Catalytic component of the exosome, involved in RNA processing and degradation; binds Gsp1p/Ran and enhances the GEF activity of Srm1p; implicated in mitotic control; homologous to the E. coli RNase R of the RNase II family
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SET6
  • YPL165C
    		•  The BioGRID Database Seperator Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YER156C
  • YER156C
    		•  The BioGRID Database Seperator Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKI3
  • SKI5
  • YPR189W
    		•  The BioGRID Database Seperator Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski2p and Ski8p; required for repressing propagation of dsRNA viruses
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS4
  • END13
  • GRD13
  • VPT10
  • YPR173C
    		•  The BioGRID Database Seperator AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMR1
  • BSD1
  • SSC1
  • LDB1
  • YGL167C
    		•  The BioGRID Database Seperator High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
    Gene Ontology: [View List]
    Positive Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IDH2
  • YOR136W
    		•  The BioGRID Database Seperator Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM3
  • PTH1
  • YOR106W
    		•  The BioGRID Database Seperator Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins
    Gene Ontology: [View List]
    Positive Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP8
  • YMR223W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZRC1
  • OSR1
  • YMR243C
    		•  The BioGRID Database Seperator Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG9
  • YNL219C
    		•  The BioGRID Database Seperator Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OCA2
  • YNL056W
    		•  The BioGRID Database Seperator Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIM9
  • YMR063W
    		•  The BioGRID Database Seperator Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERV46
  • FUN9
  • YAL042W
    		•  The BioGRID Database Seperator Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EDS1
  • YBR033W
    		•  The BioGRID Database Seperator Putative zinc cluster protein; YBR033W is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUM1
  • PAC12
  • YDR150W
    		•  The BioGRID Database Seperator Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Hoffman-Sommer M (2009) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUS1
  • YBR111W-A
    		•  The BioGRID Database Seperator Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YBR235W
  • YBR235W
    		•  The BioGRID Database Seperator Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT10
  • YBR264C
    		•  The BioGRID Database Seperator GTP binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DSK2
  • YMR276W
    		•  The BioGRID Database Seperator Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Liu C (2009) [19]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD23
  • YEL037C
    		•  The BioGRID Database Seperator Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Liu C (2009) [19]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Zhao R (2005) [489]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PKR1
  • YMR123W
    		•  The BioGRID Database Seperator V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Davis-Kaplan SR (2006) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT109
  • KIM2
  • REM50
  • YLL002W
    		•  The BioGRID Database Seperator Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Fillingham J (2008) [158]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIT2
  • YBR270C
    		•  The BioGRID Database Seperator Bit2p
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHK1
  • YBR274W
    		•  The BioGRID Database Seperator Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ANP1
  • MNN8
  • GEM3
  • YEL036C
    		•  The BioGRID Database Seperator Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RML2
  • YEL050C
    		•  The BioGRID Database Seperator Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
    Gene Ontology: [View List]
    Positive Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIM1
  • YEB1
  • YER016W
    		•  The BioGRID Database Seperator Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIR1
  • PIP1
  • YER032W
    		•  The BioGRID Database Seperator Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BST1
  • PER17
  • YFL025C
    		•  The BioGRID Database Seperator GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
    Gene Ontology: [View List]
    Positive Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRB1
  • CVT1
  • YEL060C
    		•  The BioGRID Database Seperator Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TSA2
  • YDR453C
    		•  The BioGRID Database Seperator Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPB3
  • YBR278W
    		•  The BioGRID Database Seperator Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PGS1
  • PEL1
  • YCL003W
  • YCL004W
    		•  The BioGRID Database Seperator Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCS1
  • YDL226C
    		•  The BioGRID Database Seperator ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT2
  • YTA5
  • YHS4
  • YDL007W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HUR1
  • YGL168W
    		•  The BioGRID Database Seperator Protein required for hydroxyurea resistance; has possible roles in DNA replication and maintenance of proper telomere length
    Gene Ontology: [View List]
    Positive Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.